Share：
Share this content in WeChat
X
[Chinese][PDF]83876
• Clinical Article •
The differential diagnosis value of MRI apparent diffusion coefficient value combined with dynamic contrast enhanced MRI time-intensity curve type for mass plasma cell mastitis and breast cancer
YANG Yiwen  HU Chunhong  ZHU Mo  YANG Ling  MA Xinxing 

Cite this article as: Yang YW, Hu CH, Zhu M, et al. The differential diagnosis value of MRI apparent diffusion coefficient value combined with dynamic contrast enhanced MRI time-intensity curve type for mass plasma cell mastitis and breast cancer. Chin J Magn Reson Imaging, 2019, 10(7): 530-534. DOI:10.12015/issn.1674-8034.2019.07.010.


[Abstract] Objective: To investigate the differential diagnosis value of MRI apparent diffusion coefficient (ADC) and relative apparent diffusion coefficient (rADC) combined with dynamic contrast enhanced MRI (DCE-MRI) time-intensity curve (TIC) for mass plasma cell mastitis (PCM) and breast cancer.Materials and Methods: MRI data of 21 cases of mass PCM and 31 cases of breast cancer confirmed by pathology were retrospectively analyzed. The mean ADC values of lesions, ipsilateral ectopectoralis and contralateral breast glands were measured, then calculate the mean relative apparent diffusion coefficient (rADC) values. TIC was drafted according to DCE-MRI data. MRI findings and TIC types of mass PCM and breast cancer were compared by χ2 test or Fisher exact probability test. The mean ADC and rADC values were compared by independent sample t test. P<0.05 was considered statistically significant. Based on the pathological results, the non-parametric receiver operating characteristic curve (ROC) of ADC and rADC values was drawn. A logistic regression analysis was conducted to calculate the combination factors of ADC, rADC values combined with TIC types, then ROC of the factors was drafted to figure out the differential diagnosis value of combination test for mass PCM and breast cancer.Results: Mass PCM lesions were mostly located in the posterior area of areola with an irregular shape and rough margins, and often accompanied by duct dilatation. In DCE-MRI, PCM lesions generally showed significant enhancement, and the TIC types were generally Ⅰ or Ⅱ (90.5%). The mean ADC, rADC1, and rADC2 values of PCM were (1.17±0.09)×10-3 mm2/s, 0.79±0.08 and 0.61±0.10, these values were higher than those of breast cancer, and the difference were statistically significant (P<0.05). The diagnostic threshold of mean ADC value was 1.47×10-3 mm2/s, the area under the curve (AUC) was 0.897, the sensitivity was 95.2%, and the specificity was 77.4%. The specificity of the mean rADC value is higher than the mean ADC value. When combined with TIC type, the diagnostic efficiency and sensitivity of ADC and rADC values increased, and the specificity increased except for rADC1.Conclusions: The mean ADC, rADC values have differential diagnostic value for mass PCM and breast cancer, the diagnostic efficiency is increased when DCE-MRI TIC types were combined.
[Keywords] plasma cell mastitis；breast cancer；apparent diffusion coefficient value；dynamic contrast enhanced；magnetic resonance imaging

YANG Yiwen Department of Radiology, the First Affiliated Hospital of Suzhou University, Suzhou 215006, China

HU Chunhong Department of Radiology, the First Affiliated Hospital of Suzhou University, Suzhou 215006, China

ZHU Mo Department of Radiology, the First Affiliated Hospital of Suzhou University, Suzhou 215006, China

YANG Ling Department of Radiology, the First Affiliated Hospital of Suzhou University, Suzhou 215006, China

MA Xinxing* Department of Radiology, the First Affiliated Hospital of Suzhou University, Suzhou 215006, China

*Correspondence to: Ma XX, E-mail: xinxingma@suda.edu.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS  Scientific and Technological Project of Promoting Youth through Science and Education in Suzhou No. KJXW2016008
Received  2019-01-29
Accepted  2019-05-22
DOI: 10.12015/issn.1674-8034.2019.07.010
Cite this article as: Yang YW, Hu CH, Zhu M, et al. The differential diagnosis value of MRI apparent diffusion coefficient value combined with dynamic contrast enhanced MRI time-intensity curve type for mass plasma cell mastitis and breast cancer. Chin J Magn Reson Imaging, 2019, 10(7): 530-534. DOI:10.12015/issn.1674-8034.2019.07.010.

[1]
耿翠芝，吴祥德．浆细胞性乳腺炎的诊断与治疗．临床外科杂志, 2007, 15(6): 20-23.
[2]
贺小平，苗重昌，周莹，等．肉芽肿性乳腺炎的MRI表现及鉴别诊断.临床放射学杂志, 2018, 44(10): 1648-1653.
[3]
崔文静，许静，罗松，等. MRI在浆细胞性乳腺炎诊断及分型中的价值.实用放射学杂志, 2015, 31(1): 46-49.
[4]
Yang L, Jian Z, Yu-Hui Z, et al. IL-6/STAT3 signaling pathway is activated in plasma cell mastitis. Int J Clin Exp Pathol, 2015, 8(10): 12541-12548.
[5]
Kuhl CK, Mielcareck P, Klaschik S, et al. Dynamic breast MR imaging: are signal intensity time course data useful for differential diagnosis of enhancing lesions? Radiology, 1999, 211(1): 101-110.
[6]
高才良，乐暾，蔡福玲，等．动态增强MRI及扩散加权成像对乳腺癌的诊断价值研究进展．磁共振成像, 2016, 7(3): 235-240.
[7]
范光荣，陈翠芬，朱志军，等．磁共振表观扩散系数对非哺乳期乳腺炎和乳腺癌的鉴别诊断价值．临床放射学杂志, 2015, 41(4): 544-547.
[8]
Zhao J, Guan H, Li M, et al. Significance of the ADC ratio in the differential diagnosis of breast lesions. Acta Radiologica, 2016, 57(4): 422-429.
[9]
Bougias H, Ghiatas A, Priovolos D, et al. Whole-lesion apparent diffusion coefficient (ADC) metrics as a marker of breast tumor characterization-comparison between ADC value and ADC entropy. Br J Radiol, 2016, 89(1068): 20160304.
[10]
Yılmaz E, Sarı O, Yılmaz A, et al. Diffusion-weighted imaging for the discrimination of benign and malignant breast masses, utility of ADC and relative ADC. J Belg Soc Radiol, 2018, 102(1): 24.
[11]
徐琳，汪登斌，王丽君，等. MR-DWI的ADC与rADC在乳腺疾病良恶性鉴别诊断中的比较．放射学实践, 2014, 29(10): 1103-1107.

PREV Application of texture analysis in dynamic contrast-enhanced MRI for differentiation of renal cell carcinoma subtypes
NEXT The applied value of multiparametric MRI in differentiating uterine carcinosarcoma from low risk endometrial carcinoma
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn