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• Clinical Article •
The study on the value of DKI quantitative parameters in the differential diagnosis of benign and malignant ovarian tumors and correlation with Ki-67
WANG Lifang  SONG Xiaoli  NIU Jinliang  REN Honghong 

Cite this article as: Wang LF, Song XL, Niu JL, et al. The study on the value of DKI quantitative parameters in the differential diagnosis of benign and malignant ovarian tumors and correlation with Ki-67. Chin J Magn Reson Imaging, 2019, 10(8): 589-593. DOI:10.12015/issn.1674-8034.2019.08.006.


[Abstract] Objective: To evaluate the value of diffusion kurtosis imaging (DKI) and diffusion weighted imaging (DWI) parameters in differentiating benign and malignant ovarian tumors, and the correlation with Ki-67 expression.Materials and Methods: 48 consecutive patients with pathologically confirmed a total of 55 ovarian tumors, including 23 ovarian benign tumors (25 lesions) and 25 malignant tumors (30 lesions). Patients underwent pelvic MRI scan, DKI and DWI sequence scan before surgery to obtain the mean diffusivity (MD) value, the fractional anisotropy (FA) value, the mean kurtosis (MK) value and the apparent diffusion coefficient (ADC) value of the tumors. Ki-67 immunohistochemical staining was performed on the postoperative pathological specimens. The independent sample t test was used to compare the difference of MK value, MD value, FA value and ADC value between the two groups. The receiver operating characteristic (ROC) curve was used to evaluate the diagnostic efficacy of each parameter in the differential diagnosis of benign and malignant ovarian tumors. Spearman correlation analysis was applied to confirm the correlation between each parameter value and Ki-67.Results: The MK value was significantly higher in malignant tumor group (0.85±0.1) than in benign tumor group (0.62±0.11), t=-6.156, P<0.001. Whereas the MD and ADC values were significantly lower in malignant tumors group than in benign tumor group [(1.54±0.34)×10-3 mm2/s vs (1.1±0.29)×10-3 mm2/s; (1.23±0.19)×10-3 mm2/s vs (1.0±0.15)×10-3 mm2/s], respectively, t=5.285, 4.962, P<0.001). There was no significant difference in FA values between the benign and malignant groups (t= 0.808, P=0.422). Moreover, MK showed relatively higher AUC compared with MD and ADC in differentiating benign and malignant ovarian tumors with the area under the ROC curve (AUC) of 0.88, sensitivity of 0.81 and specificity of 0.84. MK value showed a positive association with Ki-67(r=0.62, P<0.001). While MD value and ADC value were negatively correlated with Ki-67(r=-0.55, -0.50, P <0.001). No significant correlation was found between FA value and Ki-67.Conclusions: DKI and DWI quantitative parameters allow a quantitative imaging technique to reflect the proliferative of ovarian tumors, which can be applied as the biological indicator in differentiating benign and malignant ovarian tumors.
[Keywords] ovarian tumor；magnetic resonance imaging；diffusion kurtosis imaging；mean kurtosis；diffusion weighted imaging

WANG Lifang Shanxi Medical University, Taiyuan 030001, China

SONG Xiaoli Department of Imaging, the Second Hospital of Shanxi Medical University, Taiyuan 030001, China

NIU Jinliang* Department of Imaging, the Second Hospital of Shanxi Medical University, Taiyuan 030001, China

REN Honghong Department of Imaging, the Second Hospital of Shanxi Medical University, Taiyuan 030001, China

*Correspondence to: Niu JL, E-mail: sxlscjy@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Shanxi Research and Development Project No.201803D421061 Shanxi Youth Science and Technology Research Foundation No.201801D221116 Shanxi Natural Science Foundation No.201701D121142 Shanxi Returned Overseas Students Research Funding Project No.2016-119
Received  2019-03-06
Accepted  2019-05-10
DOI: 10.12015/issn.1674-8034.2019.08.006
Cite this article as: Wang LF, Song XL, Niu JL, et al. The study on the value of DKI quantitative parameters in the differential diagnosis of benign and malignant ovarian tumors and correlation with Ki-67. Chin J Magn Reson Imaging, 2019, 10(8): 589-593. DOI:10.12015/issn.1674-8034.2019.08.006.

[1]
Siegel R, Ma J, Zou Z, et al. Cancer statistics. CA Cancer J Clin, 2014, 64(1): 9-29.
[2]
Dolgun ZN, Kabaca C, Ateş Karateke, et al. The use of human epididymis 4 and cancer antigen 125 tumor markers in the benign or malignant differential diagnosis of pelvic or adnexal masses. Balkan Med J, 2017, 34(2): 156-162.
[3]
Pi S, Cao R, Qiang JW, et al. Utility of DWI with quantitative ADC values in ovarian tumors: a meta-analysis of diagnostic test performance. Acta Radiol, 2018, 59(11): 1386-1394.
[4]
Horta M, Cunha TM. Sex cord-stromal tumors of the ovary: a comprehensive review and update for radiologists. Diagn interv Radiol, 2015, 21(4): 277-286.
[5]
Fan X, Zhang H, Meng S, et al. Role of diffusion-weighted magnetic resonance imaging in differentiating malignancies from benign ovarian tumors. Int J Clin Exp Med, 2015, 8(11): 19928-19937.
[6]
Jensen JH, Helpern JA, Ramani A, et al. Diffusional kurtosis imaging: The quantification of non-gaussianwater diffusion by means of magnetic resonance imaging. Magn Reson Med, 2005, 53(6): 1432-1440.
[7]
闫坤，胡莎莎，杨品，等．磁共振扩散峰度成像在肿瘤中的研究进展.磁共振成像, 2016, 7(8)：635-640.
[8]
Sun K, Chen X, Chai W, et al. Breast cancer: Diffusion kurtosis MR imaging-diagnostic accuracy and correlation with clinical-pathologic factors. Radiol, 2015, 277(1): 46-55.
[9]
张晓莉，吴刚，谢如意，等．体素内不相干运动成像和扩散峰度成像在下肢良恶性骨与软组织肿瘤鉴诊断中的价值．磁共振成像, 2018, 9(7)：525-532.
[10]
于歌，孙佳宁，冯晓玲．上皮性卵巢肿瘤组织中PSMD10、Ki67的表达及其临床病理意义．实用肿瘤学杂志, 2017, 12(2): 112-116.
[11]
姚新宇，许卫，万璐，等．磁共振弥散加权成像联合增强扫描诊断卵巢常见囊性肿瘤．中国医学影像技术, 2016, 32(1): 99-103.
[12]
Baliyan V, Das CJ, Sharma R, et al. Diffusion weighted imaging: Technique and applications. World J Radiol, 2016, 8(9): 785-798.
[13]
李婷，鲁伦博，卓瑶瑶，等．扩散峰度成像联合动态对比增强MRI诊断乳腺良恶性病变的价值．中华放射学杂志, 2018, 52(6): 436-441.
[14]
Li HM, Zhao SH, Qiang JW, et al. Diffusion kurtosis imaging for differentiating borderline from malignant epithelial ovarian tumors: A correlation with Ki-67 expression. J Magn Reson Imaging, 2017, 46(5): 1499-1506.
[15]
杨明瑞，姜兴岳，聂泰明，等．磁共振扩散峰度成像在星形细胞肿瘤分级中的应用．实用放射学杂志, 2015, 31(5): 714-717.
[16]
索学玲，龚启勇. DWI技术在中枢神经系统中的应用及研究进展．放射学实践, 2018, 33(2)：210-214.
[17]
朱庆强，朱文荣，叶靖，等．扩散峰度成像评价肾透明细胞癌恶性程度的价值．中华放射学杂志, 2017, 51(3): 188-191.
[18]
成芳，所世腾，康记文，等. MR扩散峰度成像在浸润性乳腺癌分级及与预后因素的相关性应用研究．磁共振成像, 2017, 8(3): 164-169.

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