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Differential diagnosis of diffusion magnetic resonance quantitative parameters in breast carcinoma in situ and invasive breast cancer
ZHANG Yong 

Cite this article as: Zhang Y. Differential diagnosis of diffusion magnetic resonance quantitative parameters in breast carcinoma in situ and invasive breast cancer. Chin J Magn Reson Imaging, 2019, 10(8): 604-608. DOI:10.12015/issn.1674-8034.2019.08.009.


[Abstract] Objective: To investigate the differential diagnosis of breast carcinoma in situ and invasive breast cancer by using the ADC value and the histogram parameters from diffusion weighted imaging (DWI).Materials and Methods: A total of 137 patients with breast cancer, including 37 breast cancers in situ, 31 invasive breast cancers in grade Ⅰ , 40 cases of invasive breast cancer with grade Ⅱ and 29 cases of invasive breast cancer with grade Ⅲ were systematically collected in this study. DWI was used to obtain the ADC values of tumor location and histogram parameters by Siemens MR postprocessing workstation and MATLAB software respectively. Mann-Whitney test and ROC curve were used to evaluate the differential diagnosis between breast carcinoma in situ and invasive carcinoma, as well as different grades of invasive breast cancer.Results: There was significant difference in ADC between breast carcinoma in situ and invasive breast cancer (P<0.029). The area under the curve (AUC) was 0.712, the sensitivity was 0.647, and the specificity was 0.842, ADC was not significantly different in different grades of invasive breast cancer. The maximum intensity of histogram parameters was significantly different in primary breast cancer and invasive breast cancer, and the maximum intensity was found in primary breast cancer VS invasive breast cancer (P=0.037, AUC=0.699, sensitivity 0.671, specificity 0.868), Ⅰ grade of invasive breast cancer VS the Ⅱ grade of invasive breast cancer (P=0.024, AUC=0.703, sensitivity 0.725, specificity 0.684), Ⅱ grade of invasive breast cancer and Ⅲ grade of invasive breast cancer (P<0.01, AUC=0.777, sensitivity 0.700, specificity 0.862).Conclusions: There is statistical difference in ADC between breast carcinoma in situ and invasive breast cancer. The histogram parameters (maximum intensity value) of diffusion magnetic resonance imaging are found with statistical differences in breast carcinoma in situ and invasive breast cancer as well as different grades of invasive breast cancer.
[Keywords] diffusion weighted imaging；apparent diffusivity coefficient；histogram parameters；breast carcinoma in situ；invasive breast cancer

ZHANG Yong* Department of Radiology, Yankuang Group General Hospital, Zoucheng 273500, China

*Correspondence to: Zhang Y, E-mail: zhangyongykzy@163.com

Conflicts of interest   None.

Received  2018-12-15
Accepted  2019-02-18
DOI: 10.12015/issn.1674-8034.2019.08.009
Cite this article as: Zhang Y. Differential diagnosis of diffusion magnetic resonance quantitative parameters in breast carcinoma in situ and invasive breast cancer. Chin J Magn Reson Imaging, 2019, 10(8): 604-608. DOI:10.12015/issn.1674-8034.2019.08.009.

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