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• Clinical Article •
Preliminary study of magnetic resonance dynamic contrast enhancement combined with diffusion weighted imaging to identify high grade glioma recurrence and treatment-related changes
REN Longfei  ZHANG Hui  WANG Xiaochun  TAN Yan  QIN Jiangbo 

Cite this article as: Ren LF, Zhang H, Wang XC, et al. Preliminary study of magnetic resonance dynamic contrast enhancement combined with diffusion weighted imaging to identify high grade glioma recurrence and treatment-related changes. Chin J Magn Reson Imaging, 2019, 10(9): 655-660. DOI:10.12015/issn.1674-8034.2019.09.004.


[Abstract] Objective: To investigate the value of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) and diffusion weighted imaging (DWI) in identifying recurrence and treatment-related changes of high grade glioma.Materials and Methods: Thirty-two patients with cerebral glioma resection and abnormal enhancement after radio-chemotherapy (22 patients had recurrence and 10 patients had treatment-related changes) were collected. All patients undergone routine magnetic resonance imaging, enhancement, DWI, DCE imaging within 2 months after the radio-chemotherapy. Ktrans, Kep, Ve, iAUC perfusion pseudo-color map and ADC map were obtained using post-processing work station, and their values of enhancement region were also calculated separately. The differences in parameters between recurrence and treatment-related changes were evaluated using Wilcoxon test, and the receiver operating characteristic (ROC) curve was plotted to calculate sensitivity and specificity with the area under the curve.Results: The higher Ktrans and iAUC values were observed in recurrence group (P<0.05). The area under Ktrans and iAUC curves were 0.973 and 0.941,the sensitivity and specificity were 95.5%, 95.5% and 90%, 80% respectively, using the threshold of 0.128 and 0.152. The recurrence group had the lower average ADC value than the treatment-related changes group (P<0.05), and the area under the average ADC curve was 0.864 (sensitivity and the specificity of 86.4% and 80%, respectively). The Ktrans value had the highest diagnostic efficacy, the sensitivity can improve to 100% on detecting recurrence when incorporating Ktrans and ADC values.Conclusions: DCE-MRI combined with DWI has important clinical value on the differential diagnosis between recurrence and treatment-related changes in high grade glioma.
[Keywords] glioma；recurrence；magnetic resonance imaging；diagnosis, differential

REN Longfei Department of Medical Imaging, Shanxi Medical University, Shanxi Province, Taiyuan 030000, China

ZHANG Hui* Department of Radiology, the First Hospital of Shanxi Medical University, Shanxi Province, Taiyuan 030000, China

WANG Xiaochun Department of Radiology, the First Hospital of Shanxi Medical University, Shanxi Province, Taiyuan 030000, China

TAN Yan Department of Radiology, the First Hospital of Shanxi Medical University, Shanxi Province, Taiyuan 030000, China

QIN Jiangbo Department of Radiology, the First Hospital of Shanxi Medical University, Shanxi Province, Taiyuan 030000, China

*Correspondence to: Zhang H, E-mail: zhanghui_mr@163.com

Conflicts of interest   None.

Received  2019-02-10
Accepted  2019-05-26
DOI: 10.12015/issn.1674-8034.2019.09.004
Cite this article as: Ren LF, Zhang H, Wang XC, et al. Preliminary study of magnetic resonance dynamic contrast enhancement combined with diffusion weighted imaging to identify high grade glioma recurrence and treatment-related changes. Chin J Magn Reson Imaging, 2019, 10(9): 655-660. DOI:10.12015/issn.1674-8034.2019.09.004.

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