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• Clinical Article •
fMRI study of inhibitory control network in heroin addicts with different genotypes of DRD2 TaqIA
LI Xiaohuai  ZHU Guoping  CAI Guanke  JING Jiabing  WANG Fan  LIU Wei  SHI Hong  HU Feng  WANG Wei 

Cite this article as: Li XH, Zhu GP, Cai GK, et al. fMRI study of inhibitory control network in heroin addicts with different genotypes of DRD2 TaqIA. Chin J Magn Reson Imaging, 2019, 10(9): 661-666. DOI:10.12015/issn.1674-8034.2019.09.005.


[Abstract] Objective: To investigate the differences in inhibition control networks between different genotype heroin addicts of DRD2 TaqIA.Materials and Methods: A total of 57 heroin addicts were recruited. The DRD2 TaqIA gene type was divided into A+ group and A-type group, matching 46 healthy individuals. Firstly, three groups of impulsive scales were evaluated, and then the right inferior frontal gyrus was used as the whole brain functional connection.Results: The differences brain network were statistically analyzed between the heroin group and the healthy control group, the A+ group and the A-type group. The total scores of impulses, behavioral impulses and unplanned impulses in heroin group were significantly higher than those in normal group, but there was no significant difference between type A+ group and A- type group. Compared with the normal group, the functional connections between the right inferior frontal gyrus and bilateral posterior cingulate, anterior cuneiform, lingual gyrus and talus gyrus were enhanced, and bilateral parietal lobe were decreased in heroin addiction group. Compared with the A-type group, the functional connections between the right inferior frontal gyrus and cerebellum were enhanced, and bilateral anterior cingulate, medial prefrontal and left insular lobes were decreased in A+ type group.Conclusions: Heroin addicts have higher psychological impulsivity and abnormal control network; compared with A-genotype, A+ genotype heroin addicts have less inhibition and control ability, and may be more likely to take drugs or relapse.
[Keywords] heroin dependence；receptors, dopamine d2；alleles；magnetic resonance imaging

LI Xiaohuai Department of Nuclear Medicine, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China

ZHU Guoping Department of Radiology, Fourth Affiliated Hospital of Medical College of Zhejiang University, Yiwu 322000, China

CAI Guanke Department of Nuclear Medicine, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China

JING Jiabing Department of Radiology, First People's Hospital of Qingyang City, Gansu Province, Qingyang 745000, China

WANG Fan Department of Nuclear Medicine, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China

LIU Wei Department of Nuclear Medicine, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China

SHI Hong Department of Nuclear Medicine, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China

HU Feng Department of Nuclear Medicine, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China

WANG Wei* Department of Nuclear Medicine, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China

*Correspondence to: Wang W, E-mail: tdwangw@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  Project of National Natural Science Foundation of China No. 8147648
Received  2019-01-28
Accepted  2019-05-25
DOI: 10.12015/issn.1674-8034.2019.09.005
Cite this article as: Li XH, Zhu GP, Cai GK, et al. fMRI study of inhibitory control network in heroin addicts with different genotypes of DRD2 TaqIA. Chin J Magn Reson Imaging, 2019, 10(9): 661-666. DOI:10.12015/issn.1674-8034.2019.09.005.

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