• Clinical Article •
fMRI study of inhibitory control network in heroin addicts with different genotypes of DRD2 TaqIA
Cite this article as: Li XH, Zhu GP, Cai GK, et al. fMRI study of inhibitory control network in heroin addicts with different genotypes of DRD2 TaqIA. Chin J Magn Reson Imaging, 2019, 10(9): 661-666. DOI:10.12015/issn.1674-8034.2019.09.005.
| [Abstract] Objective: To investigate the differences in inhibition control networks between different genotype heroin addicts of DRD2 TaqIA.Materials and Methods: A total of 57 heroin addicts were recruited. The DRD2 TaqIA gene type was divided into A+ group and A-type group, matching 46 healthy individuals. Firstly, three groups of impulsive scales were evaluated, and then the right inferior frontal gyrus was used as the whole brain functional connection.Results: The differences brain network were statistically analyzed between the heroin group and the healthy control group, the A+ group and the A-type group. The total scores of impulses, behavioral impulses and unplanned impulses in heroin group were significantly higher than those in normal group, but there was no significant difference between type A+ group and A- type group. Compared with the normal group, the functional connections between the right inferior frontal gyrus and bilateral posterior cingulate, anterior cuneiform, lingual gyrus and talus gyrus were enhanced, and bilateral parietal lobe were decreased in heroin addiction group. Compared with the A-type group, the functional connections between the right inferior frontal gyrus and cerebellum were enhanced, and bilateral anterior cingulate, medial prefrontal and left insular lobes were decreased in A+ type group.Conclusions: Heroin addicts have higher psychological impulsivity and abnormal control network; compared with A-genotype, A+ genotype heroin addicts have less inhibition and control ability, and may be more likely to take drugs or relapse. |
| [Keywords] heroin dependence；receptors, dopamine d2；alleles；magnetic resonance imaging |
LI Xiaohuai Department of Nuclear Medicine, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China
ZHU Guoping Department of Radiology, Fourth Affiliated Hospital of Medical College of Zhejiang University, Yiwu 322000, China
CAI Guanke Department of Nuclear Medicine, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China
JING Jiabing Department of Radiology, First People's Hospital of Qingyang City, Gansu Province, Qingyang 745000, China
WANG Fan Department of Nuclear Medicine, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China
LIU Wei Department of Nuclear Medicine, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China
SHI Hong Department of Nuclear Medicine, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China
HU Feng Department of Nuclear Medicine, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China
WANG Wei* Department of Nuclear Medicine, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China
*Correspondence to: Wang W, E-mail: tdwangw@126.com
Conflicts of interest None.
| ACKNOWLEDGMENTS Project of National Natural Science Foundation of China No. 8147648 |
| Received 2019-01-28 |
| Accepted 2019-05-25 |
| DOI: 10.12015/issn.1674-8034.2019.09.005 |
| Cite this article as: Li XH, Zhu GP, Cai GK, et al. fMRI study of inhibitory control network in heroin addicts with different genotypes of DRD2 TaqIA. Chin J Magn Reson Imaging, 2019, 10(9): 661-666. DOI:10.12015/issn.1674-8034.2019.09.005. |
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