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• Clinical Article •
Clinical application of bi-ventricular strains in ischemic cardiomyopathy and non-ischemic dilated cardiomyopathy
CAO Huixiao  XU Yi  ZHU Yinsu  ZHU Xiaomei  LIU Wangyan  TANG Lijun 

Cite this article as: Cao HX, Xu Y, Zhu YS, et al. Clinical application of bi-ventricular strains in ischemic cardiomyopathy and non-ischemic dilated cardiomyopathy. Chin J Magn Reson Imaging, 2019, 10(9): 667-673. DOI:10.12015/issn.1674-8034.2019.09.006.


[Abstract] Objective: The purpose of this study was to evaluate if cardiac magnetic resonance feature-tracking (MR-FT) could be applied to detect the differences of both ventricular function between ischemic cardiomyopathy (ICM) and non-ischemic dilated cardiomyopathy (NIDCM).Materials and Methods: Twenty-five subjects with NIDCM and 14 subjects with ICM underwent cardiac magnetic resonance imaging and late gadolinium enhancement (LGE). Cardiac function including global and segmental strains of both ventricles was analyzed using feature tracking technology to obtain myocardial 3D strain parameter values in all directions. Analysis of Mann-Whitney U-test or t-test were used for above parameters. For those significant different parameters, Pearson linear correlation analysis and Logistic regression analysis was carried out. For RVEF and RV LS, receiver operating characteristic (ROC) curve was used to analyze their diagnostic performance in distinguishing NIDCM from ICM.Results: Compared with ICM, both ventricular ejection fractions significantly decreased (P<0.001) and all global strain indicators of LV significantly decreased in the NIDCM (P<0.01). Left ventricular ejection fraction (LVEF) in NIDCM was correlated with both circumferential strain (r=-0.849, P<0.001) and longitudinal strain (r=-0.759, P<0.001) significantly. LVEF in ICM was correlated with radial strain (r=0.735, P<0.01), circumferential strain (r=-0.746, P<0.01) and longitudinal strain (r=-0.708, P<0.01) significantly. The peak values of radial strain, circumferential strain and longitudinal strain of LGE-positive myocardial segments in two groups were lower than those in LGE-negative ones [ICM: (32.77±27.40)% vs (52.22±29.16)%, (-26.16±14.90)% vs (-31.43±12.80)%, (-18.29±9.80%) vs (-23.54±11.70)%, P<0.001. NIDCM: (14.99±20.47)% vs (22.36±21.92)%, (-11.53±7.77)% vs (-14.70±8.31)%, (-11.85±7.20)% vs (-13.94±7.99)%, P<0.001]. The peak values of radial strain, circumferential strain and longitudinal strain of LGE-negative myocardial segments in NIDCM were lower than ICM [(14.99±20.47)% vs (32.77±27.40)%, (-11.53±7.77)% vs (-26.16±14.90)%, (-11.85±7.20)% vs (-18.29±9.80)%, P<0.01].Conclusions: MR-FT can evaluate the bi-ventricular function of NIDCM and ICM from both global and local aspects, especially in the right ventricle, so as to provide more evidence for clinical diagnosis and treatment.
[Keywords] non-ischemic dilated cardiomyopathy；ischemic cardiomyopathy；magnetic resonance imaging

CAO Huixiao Department of Nuclear Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

XU Yi Department of Radiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

ZHU Yinsu Department of Radiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

ZHU Xiaomei Department of Radiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

LIU Wangyan Department of Radiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

TANG Lijun Department of Nuclear Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

*Correspondence to: Tang LJ, E-mail: tanglijun@njmu.edu.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS  This paper is funded by Jiangsu Key Medical Talents Fund No. ZDRCB2016003
Received  2019-01-14
Accepted  2019-05-22
DOI: 10.12015/issn.1674-8034.2019.09.006
Cite this article as: Cao HX, Xu Y, Zhu YS, et al. Clinical application of bi-ventricular strains in ischemic cardiomyopathy and non-ischemic dilated cardiomyopathy. Chin J Magn Reson Imaging, 2019, 10(9): 667-673. DOI:10.12015/issn.1674-8034.2019.09.006.

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