Share：
Share this content in WeChat
X
[Chinese][PDF]773158
• Review •
Progress of magnetic resonance elastography in nonalcoholic fatty liver disease
LIANG Yuanzi  LI Daowei 

Cite this article as: Liang YZ, Li DW. Progress of magnetic resonance elastography in nonalcoholic fatty liver disease. Chin J Magn Reson Imaging, 2019, 10(9): 707-710. DOI:10.12015/issn.1674-8034.2019.09.015.


[Abstract] In recent years, the prevalence of nonalcoholic fatty liver disease (NAFLD) in China is rising, and has become the largest chronic liver disease in China. Nonalcoholic fatty liver disease (NAFLD) includes nonalcoholic fatty liver disease (NAFL), nonalcoholic steatohepatitis (NASH) and its related liver cirrhosis, hepatocellular carcinoma (HCC). Among them, NASH has a higher risk of developing liver cirrhosis and hepatocellular carcinoma (HCC). Magnetic resonance elastic imaging (MRE) is of great value in the diagnosis and monitoring of the course of NAFLD. This article reviews the basic principle of MRE and its application in NAFLD.
[Keywords] fatty liver；hepatitis；hepatic fibrosis；magnetic resonance imaging

LIANG Yuanzi People's Hospital of China Medical University, Liaoning Provincial People's Hospital, Shenyang 110015, China

LI Daowei* People's Hospital of China Medical University, Liaoning Provincial People's Hospital, Shenyang 110015, China

*Corresponding to: Li DW, E-mail: lidaowei024@163.com

Conflicts of interest   None.

Received  2019-06-02
Accepted  2019-07-26
DOI: 10.12015/issn.1674-8034.2019.09.015
Cite this article as: Liang YZ, Li DW. Progress of magnetic resonance elastography in nonalcoholic fatty liver disease. Chin J Magn Reson Imaging, 2019, 10(9): 707-710. DOI:10.12015/issn.1674-8034.2019.09.015.

[1]
Stefan N, Häring HU, Cusi K. Non-alcoholic fatty liver disease: causes,diagnosis, cardiometabolic consequences,and treatment strategies. Lancet Diabetes Endocrinol, 2019, 7(4): 313-324.
[2]
Loomba R, Wolfson T, Ang B, et al. Magnetic resonance elastography predicts advanced fibrosis in patients with nonalcoholic fatty liver disease: a prospective study. Hepatology, 2014, 60(6): 1920-1928.
[3]
Younossi Z, Tacke F, Arrese M, et al. Global Perspectives on Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis. Hepatology, 2019, 69(6): 2672-2682.
[4]
中华医学会肝病学分会脂肪肝和酒精性肝病学组，中国医师协会脂肪性肝病专家委员会．非酒精性脂肪性肝病防治指南（2018年更新版）.临床肝脏病杂志, 2018, 34(5): 947-957.
[5]
Hsu C, Caussy C, Imajo K, et al. Magnetic resonance vs transient elastography analysis of patients with nonalcoholic fatty liver disease: a systematic review and pooled analysis of individual participants. Clin Gastroenterol Hepatol, 2019, 17(4): 630-637.
[6]
Singh S, Venkatesh SK, Loomba R, et al. Magnetic resonance elastography for staging liver fibrosis in non-alcoholic fatty liver disease: a diagnostic accuracy systematic review and individual participant data pooled analysis. Eur Radiol, 2016, 26(5): 1431-1440.
[7]
Dulai PS, Sirlin CB, Loomba R. MRI and MRE for non-invasive quantitative assessment of hepatic steatosis and fibrosis in NAFLD and NASH: clinical trials to clinical practice. J Hepatol, 2016, 65(5): 1006-1016.
[8]
Etchell E, Jugé L, Hatt A, et al. Liver stiffness values are lower in pediatric subjects than in adults and increase with age: a multifrequency MR elastography study. Radiology, 2017, 283(1): 222-230.
[9]
Akkaya HE, Erden A, Kuru Öz D, et al. Magnetic resonance elastography: basic principles, technique, and clinical applications in the liver. Diagn Interv Radiol, 2018, 24(6): 328-335.
[10]
Bayly PV, Garbow JR. Pre-clinical MR elastography: principles, techniques, and applications. J Magn Reson, 2018, 291(1): 73-83.
[11]
陈俊，黄永峰，宋朝昀，等．磁共振弹性图．国外医学生物工程分册, 2005, 28(2): 65-69.
[12]
Venkatesh SK, Talwalkar JA. When and how to use magnetic resonance elastography for patients with liver disease in clinical practice. Am J Gastroenterol, 2018, 113(7): 923-926.
[13]
Costa-Silva L, Ferolla SM, Lima AS, et al. MR elastography is effective for the non-invasive evaluation of fibrosis and necroinflammatory activity in patients with nonalcoholic fatty liver disease. Eur J Radiol, 2018, 98(1): 82-89.
[14]
石喻，郭启勇，张兰，等．正常人肝脏3.0 T磁共振弹性成像.中国医学影像技术, 2013, 29(6): 941-944.
[15]
Rinella ME. Nonalcoholic fatty liver disease: a systematic review. JAMA, 2015, 313(22): 2263-2273.
[16]
Singal AG, Manjunath H, Yopp AC, et al. The effect of PNPLA3 on fibrosis progression and development of hepatocellular carcinoma: a meta-analysis. Am J Gastroenterol, 2014, 109(3): 325-334.
[17]
Ajmera V, Loomba R. Can elastography differentiate isolated fatty liver from nonalcoholic steatohepatitis? Semin Liver Dis, 2018, 38(1): 14-20.
[18]
Harrison SA, Torgerson S, Hayashi PH. The natural history of nonalcoholic fatty liver disease: a clinical histopathological study. Am J Gastroenterol, 2003, 98(9): 2042-2047.
[19]
Georges PC, Hui JJ, Gombos Z, et al. Increased stiffness of the rat liver precedes matrix deposition: implications for fibrosis. Am J Physiol Gastrointest Liver Physiol, 2007, 293(6): 1147-1154.
[20]
Wells RG. The role of matrix stiffness in regulating cell behavior. Hepatology, 2008, 47(4): 1394-1400.
[21]
Chen J, Talwalkar JA, Yin M, et al. Early detection of nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease by using MR elastography. Radiology, 2011, 259(3): 749-756.
[22]
Salameh N, Larrat B, Abarca-Quinones J, et al. Early detection of steatohepatitis in fatty rat liver by using MR elastography. Radiology, 2009, 253(1): 90-97.
[23]
Ekstedt M, Hagström H, Nasr P, et al. Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up. Hepatology, 2015, 61(5): 1547-1554.
[24]
Imajo K, Kessoku T, Honda Y, et al. Magnetic resonance imaging more accurately classifies steatosis and fibrosis in patients with nonalcoholic fatty liver disease than transient elastography. Gastroenterology, 2016, 150(3): 626-637.
[25]
Park CC, Nguyen P, Hernandez C, et al. Magnetic resonance elastography vs transient elastography in detection of fibrosis and noninvasive measurement of steatosis in patients with biopsy-proven nonalcoholic fatty liver disease. Gastroenterology, 2017, 152(3): 598-607.
[26]
Loomba R, Cui J, Wolfson T, et al. Novel 3D magnetic resonance elastography for the noninvasive diagnosis of advanced fibrosis in NAFLD: a prospective study. Am J Gastroenterol, 2016, 111(7): 986-994.
[27]
Mouzaki M, Trout AT, Arce-Clachar AC, et al. Assessment of nonalcoholic fatty liver disease progression in children using magnetic resonance imaging. J Pediatr, 2018, 201(2): 86-92.
[28]
Schwimmer JB, Behling C, Angeles JE, et al. Magnetic resonance elastography measured shear stiffness as a biomarker of fibrosis in pediatric nonalcoholic fatty liver disease. Hepatology, 2017, 66(5): 1474-1485.
[29]
Xanthakos SA, Podberesky DJ, Serai SD, et al. Use of magnetic resonance elastography to assess hepatic fibrosis in children with chronic liver disease. J Pediatr, 2014, 164(1): 186-188.
[30]
Hsu C, Caussy C, Imajo K, et al. Magnetic resonance vs transient elastography analysis of patients with nonalcoholic fatty liver disease: a systematic review and pooled analysis of individual participants. Clin Gastroenterol Hepatol, 2019, 17(4): 630-637.
[31]
Cui J, Heba E, Hernandez C, et al. Magnetic resonance elastography is superior to acoustic radiation force impulse for the diagnosis of fibrosis in patients with biopsy-proven nonalcoholic fatty liver disease: a prospective study. Hepatology, 2016, 63(2): 453-461.
[32]
Xiao G, Zhu S, Xiao X, et al. `Comparison of laboratory tests, ultrasound, or magnetic resonance elastography to detect fibrosis in patients with nonalcoholic fatty liver disease: a meta-analysis. Hepatology, 2017, 66(5): 1486-1501.
[33]
Wagner M, Corcuera-Solano I, Lo G, et al. Technical failure of MR elastography examinations of the liver: experience from a large single-center study. Radiology, 2017, 284(2): 401-412.

PREV Advance researches on MRI in evaluation of pathological differentiation for hepatocellular carcinoma
NEXT A review of the research progress and idea discussion of functional magnetic resonance imaging with Tai Chi
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn