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The advances of study on apoptosis molecular imaging through magnetic resonance
ZHAO Xiangxuan  WEN Feng  LU Zaiming  GUO Qiyong 

Cite this article as: Zhao XX, Wen F, Lu ZM, et al. The advances of study on apoptosis molecular imaging through magnetic resonance. Chin J Magn Reson Imaging, 2019, 10(9): 715-720. DOI:10.12015/issn.1674-8034.2019.09.017.


[Abstract] Apoptosis (programmed cell death) plays key roles in carcinogenesis as well as other diseases including neurodegenerative disorders, cortical necrosis, myocardial infarction, ischemia reperfusion, cell therapy and rejection of organ transplantation. Non-invasive assess of apoptosis is important for diagnosis disease occurrence and development and therapeutic effects judgment. Currently, MRI is one of the widespread non-invasive diagnostic modalities. Specific biomarker of apoptosis conjugated with MR contrast agents has been used to develop molecular MR probe and in preclinical or clinical trial. This study collected literatures on apoptosis molecular MR imaging in recent decade. We summarized the progress of study on utilization of molecular biomarker of apoptosis in MR imaging. We hope our research will provide useful clues for application and extension of molecular MR imaging of apoptosis in clinic.
[Keywords] apoptosis；molecular imaging；molecular probes；magnetic resonance imaging

ZHAO Xiangxuan Department of Radiology, Shengjing Hospital of China Medical University, Liaoning Provincial Key Laboratory of Medical Imaging, Shenyang 110004, China

WEN Feng Department of Radiology, Shengjing Hospital of China Medical University, Liaoning Provincial Key Laboratory of Medical Imaging, Shenyang 110004, China

LU Zaiming* Department of Radiology, Shengjing Hospital of China Medical University, Liaoning Provincial Key Laboratory of Medical Imaging, Shenyang 110004, China

GUO Qiyong Department of Radiology, Shengjing Hospital of China Medical University, Liaoning Provincial Key Laboratory of Medical Imaging, Shenyang 110004, China

*Corresponding to: Lu ZM, E-mail: luzm@sj-hospital.org

Conflicts of interest   None.

ACKNOWLEDGMENTS  National Natural Science Foundation of China No. 31371425, 81771947 Liaoning Provincial Natural Science Foundation of China No. 20180551061
Received  2019-01-15
Accepted  2019-05-21
DOI: 10.12015/issn.1674-8034.2019.09.017
Cite this article as: Zhao XX, Wen F, Lu ZM, et al. The advances of study on apoptosis molecular imaging through magnetic resonance. Chin J Magn Reson Imaging, 2019, 10(9): 715-720. DOI:10.12015/issn.1674-8034.2019.09.017.

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