Share：
Share this content in WeChat
X
[Chinese][PDF]105480
• Review •
The advances of study on apoptosis molecular imaging through magnetic resonance
ZHAO Xiangxuan  WEN Feng  LU Zaiming  GUO Qiyong 

Cite this article as: Zhao XX, Wen F, Lu ZM, et al. The advances of study on apoptosis molecular imaging through magnetic resonance. Chin J Magn Reson Imaging, 2019, 10(9): 715-720. DOI:10.12015/issn.1674-8034.2019.09.017.


[Abstract] Apoptosis (programmed cell death) plays key roles in carcinogenesis as well as other diseases including neurodegenerative disorders, cortical necrosis, myocardial infarction, ischemia reperfusion, cell therapy and rejection of organ transplantation. Non-invasive assess of apoptosis is important for diagnosis disease occurrence and development and therapeutic effects judgment. Currently, MRI is one of the widespread non-invasive diagnostic modalities. Specific biomarker of apoptosis conjugated with MR contrast agents has been used to develop molecular MR probe and in preclinical or clinical trial. This study collected literatures on apoptosis molecular MR imaging in recent decade. We summarized the progress of study on utilization of molecular biomarker of apoptosis in MR imaging. We hope our research will provide useful clues for application and extension of molecular MR imaging of apoptosis in clinic.
[Keywords] apoptosis；molecular imaging；molecular probes；magnetic resonance imaging

ZHAO Xiangxuan Department of Radiology, Shengjing Hospital of China Medical University, Liaoning Provincial Key Laboratory of Medical Imaging, Shenyang 110004, China

WEN Feng Department of Radiology, Shengjing Hospital of China Medical University, Liaoning Provincial Key Laboratory of Medical Imaging, Shenyang 110004, China

LU Zaiming* Department of Radiology, Shengjing Hospital of China Medical University, Liaoning Provincial Key Laboratory of Medical Imaging, Shenyang 110004, China

GUO Qiyong Department of Radiology, Shengjing Hospital of China Medical University, Liaoning Provincial Key Laboratory of Medical Imaging, Shenyang 110004, China

*Corresponding to: Lu ZM, E-mail: luzm@sj-hospital.org

Conflicts of interest   None.

ACKNOWLEDGMENTS  National Natural Science Foundation of China No. 31371425, 81771947 Liaoning Provincial Natural Science Foundation of China No. 20180551061
Received  2019-01-15
Accepted  2019-05-21
DOI: 10.12015/issn.1674-8034.2019.09.017
Cite this article as: Zhao XX, Wen F, Lu ZM, et al. The advances of study on apoptosis molecular imaging through magnetic resonance. Chin J Magn Reson Imaging, 2019, 10(9): 715-720. DOI:10.12015/issn.1674-8034.2019.09.017.

[1]
Agostini M, Tucci P, Melino G. Cell death pathology: perspective for human diseases. Biochem Biophys Res Commun, 2011, 414(3): 451-455.
[2]
Zeng W, Wang X, Xu P, et al. Molecular imaging of apoptosis: from micro to macro. Theranostics, 2015, 5(6): 559-582.
[3]
魏光全，宦怡．细胞凋亡的分子影像学研究进展．国外医学临床放射学分册, 2006, 29(5): 299-303.
[4]
Tanaka Y, Ishii H, Hiraoka M, et al. Efficacy of recombinant annexin 2 for fibrinolytic therapy in a rat embolic stroke model: a magnetic resonance imaging study. Brain Res, 2007, 1165: 135-143.
[5]
Prinzen L, Miserus RJ, Dirksen A, et al. Optical and magnetic resonance imaging of cell death and platelet activation using annexin a5-functionalized quantum dots. Nano Lett, 2007, 7(1): 93-100.
[6]
Fiandalo MV, Kyprianou N. Caspase control: protagonists of cancer cell apoptosis. Exp Oncol, 2012, 34(3): 165-175.
[7]
滕皋军,崔莹.磁共振分子影像学研究进展.磁共振成像, 2014, 5(增刊1): 31-36.
[8]
Jung HI, Kettunen MI, Davletov B, et al. Detection of apoptosis using the C2A domain of synaptotagmin I. Bioconjug Chem, 2004, 15(5): 983-987.
[9]
Zhao M, Beauregard DA, Loizou L, et al. Non-invasive detection of apoptosis using magnetic resonance imaging and a targeted contrast agent. Nat Med, 2001, 7(11): 1241-1244.
[10]
Matsushima M, Naganawa S, Ikeda M, et al. Diagnostic value of SPIO-mediated breath-hold, black-blood, fluid-attenuated, inversion recovery (BH-BB-FLAIR) imaging in patients with hepatocellular carcinomas. Magn Reson Med Sci, 2010, 9(2): 49-58.
[11]
Dash R, Chung J, Chan T, et al. A molecular MRI probe to detect treatment of cardiac apoptosis in vivo. Magn Reson Med, 2011, 66(4): 1152-1162.
[12]
Figge L, Appler F, Chen HH, et al. Direct coupling of annexin A5 to VSOP yields small, protein-covered nanoprobes for MR imaging of apoptosis. Contrast Media Mol Imaging, 2014, 9(4): 291-299.
[13]
Burtea C, Ballet S, Laurent S, et al. Development of a magnetic resonance imaging protocol for the characterization of atherosclerotic plaque by using vascular cell adhesion molecule-1 and apoptosis-targeted ultrasmall superparamagnetic iron oxide derivatives. Arterioscler Thromb Vasc Biol, 2012, 32(6): e36-48.
[14]
Nishie A, Togao O, Tamura C, et al. In vitro and in vivo detection of drug-induced apoptosis using annexin V-conjugated ultrasmall superparamagnetic iron oxide (USPIO): a pilot study. Magn Reson Med Sci, 2019, 18(2): 142-149.
[15]
Schellenberger EA, Hogemann D, Josephson L, et al. Annexin V-CLIO: a nanoparticle for detecting apoptosis by MRI. Acad Radiol, 2002, 9(Suppl 2): S310-311.
[16]
Sosnovik DE, Schellenberger EA, Nahrendorf M, et al. Magnetic resonance imaging of cardiomyocyte apoptosis with a novel magneto-optical nanoparticle. Magn Reson Med, 2005, 54(3): 718-724.
[17]
Sosnovik DE, Nahrendorf M, Panizzi P, et al. Molecular MRI detects low levels of cardiomyocyte apoptosis in a transgenic model of chronic heart failure. Circ Cardiovasc Imaging, 2009, 2(6): 468-475.
[18]
杨晓锋,涂蓉.磁共振钆靶向对比剂的研究现状及展望.国际医学放射学杂志, 2016, 39(5): 549-554.
[19]
Burtea C, Laurent S, Lancelot E, et al. Peptidic targeting of phosphatidylserine for the MRI detection of apoptosis in atherosclerotic plaques. Mol Pharm, 2009, 6(6): 1903-1919.
[20]
Van Koninckxloo A, Henoumont C, Laurent S, et al. (1) H-NMR relaxometric studies of interaction between apoptosis specific MRI paramagnetic contrast agents and micellar models of apoptotic cells. Magn Reson Chem, 2016, 54(7): 568-574.
[21]
Ye D, Shuhendler AJ, Pandit P, et al. Caspase-responsive smart gadolinium-based contrast agent for magnetic resonance imaging of drug-induced apoptosis. Chem Sci, 2014, 4(10): 3845-3852.
[22]
Nejadnik H, Ye D, Lenkov OD, et al. Magnetic resonance imaging of stem cell apoptosis in arthritic joints with a caspase activatable contrast agent. ACS Nano, 2015, 9(2): 1150-1160.
[23]
梁长虹.磁共振对比剂临床应用及进展.磁共振成像, 2014, 5(增刊1): 37-42.
[24]
刘岩,任佳忠,杨国仁.分子影像技术在肿瘤细胞凋亡的研究现状及进展.肿瘤学杂志, 2017, 23(6): 496-501.
[25]
胡四龙,章英剑,周正荣.凋亡分子影像研究进展.肿瘤影像学. 2013, 22(3): 214-219.

PREV A review of the research progress and idea discussion of functional magnetic resonance imaging with Tai Chi
NEXT The review and the future of functional magnetic resonance imaging
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn