• Clinical Article •
Diffusion tensor imaging for the development of neonatal brain myelin
Cite this article as: Guo LL, Wang DH, Zhang H, et al. Diffusion tensor imaging for the development of neonatal brain myelin. Chin J Magn Reson Imaging, 2019, 10(10): 748-751. DOI:10.12015/issn.1674-8034.2019.10.006.
| [Abstract] Objective: To investigate the fractional anisotropy (FA) in various brain regions of newborns and explore the value of diffusion tensor imaging (DTI) application in the cerebral white matter myelin development.Materials and Methods: 39 term neonates (gestational age in 37——42 weeks) and 61 premature infants (corrected to 40 weeks gestational age) were investigated by routine MRI and DTI. Their perinatal medical records and nervous system examinations showed no abnormalities. FA values were detected in the regions of interest. The differences of FA values between full term and preterm neonates were explored.Results: ①FA values in the same regions of interest (ROI) had no statistic difference between left and right hemisphere (P>0.05). ②The FA values between preterm infants and full term infants in same white matter regions were different. FA values in ALIC, CCS, external capsule (EC) were statistically higher than in PLIC, centrum semiovale (CS), and middle cerebellar peduncles (MCP)(P<0.05). The FA values of FPVZ were the lowest in all ROIs; and CCS and PLIC were highest. The comparison of between FPVZ and CCS, FPVZ and PLIC had significant difference respectively (P<0.05). ③The FA values of premature and full term infants in various white matter regions were different and all values were compared in pairs. We found the values in posterior limb of internal capsule (PLIC) were higher than in anterior limb of internal capsule (ALIC), the values in occipital periventricular zone (OPVZ) were higher than in frontal periventricular zone (FPVZ), and corpus callosum splenium (CCS) were higher than corpus callosum genu (CCG). All the differences were statistically significant (P<0.05).Conclusions: FA values can be used to evaluate the myelination quantitatively. The different FA values in preterm and full term infants suggest late myelination in preterm infants. FA values reflects the difference of the myelination time. |
| [Keywords] neonate；diffusion tensor imaging；brain；myelination；magnetic resonance imaging |
GUO Lili Department of Medical Radiology, the Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Huaian 223300, China
WANG Dehang Department of Medical Radiology, the First Affliated Hospital of Nanjing Medical University, Nanjing 210029, China
ZHANG Hui Department of Medical Radiology, the Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Huaian 223300, China
TAO Weijing Department of Medical Radiology, the Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Huaian 223300, China
BO Genji * Department of Medical Radiology, the Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Huaian 223300, China
*Correspondence to: Bo GJ, E-mail: hybgj0451@163.com
Conflicts of interest None.
| Received 2018-12-15 |
| DOI: 10.12015/issn.1674-8034.2019.10.006 |
| Cite this article as: Guo LL, Wang DH, Zhang H, et al. Diffusion tensor imaging for the development of neonatal brain myelin. Chin J Magn Reson Imaging, 2019, 10(10): 748-751. DOI:10.12015/issn.1674-8034.2019.10.006. |
[1]
Hintz SR, Kendrick DE, Vohr BR, et al. Changes in neurodevelopmental outcomes at 18 and 22 months corrected age among infants of less than 25 weeks'gestational age born in 1993-1999. Pediatrics, 2005, 115(6): 1645-1651.
[2]
Volpe JJ. Cerebral white matter injury of the premature infant more common than you think. Pediatrics, 2003, 112(1): 176-180.
[3]
Counsell SJ, Allsop JM, Harrison MC, et al. Diffusion-weighted imaging of the brain in preterm infants with focal and diffuse white matter abnormality. Pediatrics, 2003, 112(1): 1-7.
[4]
Iwata S, Iwata O, Bainbridge A, et al. Abnormal white matter appearance on term FLAIR predicts neuro-developmental outcome at 6 years old following preterm birth. Int J Dev Neurosci, 2007, 25(8): 523-530.
[5]
Dyet LE, Kennea N, Counsell SJ, et al. Natural history of brain lesions in extremely preterm infants studied with serial magnetic resonance imaging from birth and neurodevelopmental assessment. Pediatrics, 2006, 118(2): 536-548.
[6]
Chau V, Poskitt KJ, McFadden DE, et al. Effect of chorioamnionitis on brain development and injury in premature newborns. Ann Neurol, 2009, 66(2): 155-164.
[7]
Thompson DK, Inder TE, Faggian N, et al. Corpus callosum alterations in very preterm infants: perinatal correlates and 2 year neurodevelopmental outcomes. Neuroimage, 2012, 59(4): 3571-3581.
[8]
Hart AR, Smith MF, Rigby AS, et al. Appearances of diffuse excessive high signal intensity (DEHSI) on MR imaging following preterm birth. Pediatr Radiol, 2010, 40(8): 1390-1396.
[9]
左克扬，罗学毛，龙晚生，等．应用ADC值对新生儿缺氧缺血性脑病追踪复查的初步研究．中国CT和MRI杂志, 2011, 9(4): 20-22.
[10]
Thayyil S, Chandrasekaran M, Taylor A, et al. Cerebral magnetic resonance biomarkers in neonatal encephalopathy: a meta-analysis. Pediatrics, 2010, 125(2): 382-395.
[11]
Chau V, Poskitt KJ, Miller SP, et a1. Advanced neuroimaging techniques for the term newborn with encephalopathy. Pediatr Neurol, 2009, 40(3): 181-188．
[12]
张晔，谢晓霖．磁共振弥散张量成像评价32例2岁内婴儿脑白质发育研究．中国继续医学教育, 2015, 7(13): 38-39.
[13]
李冰肖，柳国胜，凌雪英，等. MRI和DTI评价早产儿脑白质髓鞘发育.中国当代儿科杂志, 2016, 18(6): 476-481.
[14]
Makki MI, Hagmann C. Regional differences in interhemispheric structural fibers in healthy, term infants. J Neurosci Res, 2017, 95(3): 876-884.
[15]
Nossin-Manor R, Card D, Raybaud C, et al. Cerebral maturation in the early preterm period-A magnetization transfer and diffusion tensor imaging study using voxel-based analysis. Neuroimage, 2015, 112: 30-42.
[16]
刘岭岭,孛茹婷，杨文君，等．磁共振弥散张量成像技术在新生儿脑白质发育中的研究．磁共振成像, 2015, 6(4): 253-257.
[17]
Bartha AI, Yap KR, Miller SP, et al. The normal neonatal brain: MR imaging, diffusion tensor imaging, and 3D MR spectroscopy in healthy term neonates. AJNR Am J Neuroradiol, 2007, 28(6): 1015-1021.
[18]
Pogribna U, Yu X, Burson K, et al. Perinatal clinical antecedents of white matter microstructural abnormalities on diffusion tensor imaging in extremely preterm infants. PLoS One, 2013, 8(8): e72974.
[19]
肖江喜，郭雪梅，谢晟，等．应用弥散张量成像对正常儿童脑白质发育的初步研究.中华放射学杂志, 2005, 39(12): 1252-1255.
[20]
郭雪梅，肖江喜，谢晟，等．正常儿童脑组织成分变化-扩散张量成像的研究．实用放射学杂志, 2003, 19(10): 889-892.
[21]
Rasmussen JM, Kruggel F, Gilmore JH, et al. A novel maturation index based on neonatal diffusion tensor imaging reflects typical perinatal white matter development in humans. Int J Dev Neurosci, 2017, 56: 42-51.
