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• Clinical Article •
The value of Gd-EOB-DTPA enhanced MRI signal intensity in evaluating liver function
LÜ Qian  ZHOU Ruizhi  LI Yingduan  HUA Hui  PANG Jing  CHEN Jingjing 

Cite this article as: Lü Q, Zhou RZ, Li YD, et al. The value of Gd-EOB-DTPA enhanced MRI signal intensity in evaluating liver function. Chin J Magn Reson Imaging, 2019, 10(10): 752-756. DOI:10.12015/issn.1674-8034.2019.10.007.


[Abstract] Objective: To explore the feasibility of Gd-EOB-DTPA enhanced MRI signal intensity in evaluating liver function by analyzing the changes of relative enhancement (RE) and the ratio of liver to portal vein enhancement (LPC) in Gd-EOB-DTPA enhanced MRI.Materials and Methods: Date of 129 patients with Gd-EOB-DTPA enhanced MRI was collected. Measured and calculated RE values and LPC values. One-way ANOVA was used to compare RE and LPC values in the control group, Child-Pugh A group, Child-Pugh B group, and Child-Pugh C group. ROC curve was performed to analyze the diagnostic efficiency of RE and LPC values in evaluating liver function.Results: The mean values of RE are respectively 2.14±0.31, 1.86±0.30, 1.44±0.23, 1.18±0.18 in the control group, Child-Pugh A group, Child- Pugh B group, and Child-Pugh C group. The mean values of LPC are respectively 2.06±0.33, 1.62±0.19, 1.21±0.17, 0.93±0.12 in the control group, Child-Pugh A group, Child-Pugh B group, and Child-Pugh C group. There were significant differences in RE and LPC values between the control group and different Child-Pugh grading groups (P<0.05). There were significant differences in RE and LPC between any two groups (P<0.05). The area under the curve of RE and LPC was 0.762 and 0.892 in the control group and Child-Pugh A group respectively. The area under the curve of RE and LPC was 0.880 and 0.942 in Child-Pugh A group and B group respectively. The area under the curve of RE and LPC was 0.817 and 0.920 in Child-Pugh B group and C group respectively. The area under the curve of RE and LPC was 0.936 and 0.975 in the control group+Child-Pugh A group and Child-Pugh B+C group respectively.Conclusions: Gd-EOB-DTPA enhanced MRI signal intensity is helpful to evaluate liver function and to differentiate the degree of liver function impairment.
[Keywords] liver function；magnetic resonance imaging；Gd-EOB-DTPA；signal intensity

LÜ Qian Department of Radiology, Affiliated Hospital of Qingdao University, Qingdao 266003, China

ZHOU Ruizhi Department of Radiology, Affiliated Hospital of Qingdao University, Qingdao 266003, China

LI Yingduan Department of Radiology, Affiliated Hospital of Qingdao University, Qingdao 266003, China

HUA Hui Department of Thyroid Surgery, Affiliated Hospital of Qingdao University, Qingdao 266003, China

PANG Jing Department of Radiology, Affiliated Hospital of Qingdao University, Qingdao 266003, China

CHEN Jingjing * Department of Radiology, Affiliated Hospital of Qingdao University, Qingdao 266003, China

*Correspondence to: Chen JJ, E-mail: chenjingjingsky@126.com

Conflicts of interest   None.

Received  2019-04-04
DOI: 10.12015/issn.1674-8034.2019.10.007
Cite this article as: Lü Q, Zhou RZ, Li YD, et al. The value of Gd-EOB-DTPA enhanced MRI signal intensity in evaluating liver function. Chin J Magn Reson Imaging, 2019, 10(10): 752-756. DOI:10.12015/issn.1674-8034.2019.10.007.

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