Share：
Share this content in WeChat
X
[Chinese][PDF]880137
• Clinical Article •
The value of Gd-EOB-DTPA enhanced MRI signal intensity in evaluating liver function
LÜ Qian  ZHOU Ruizhi  LI Yingduan  HUA Hui  PANG Jing  CHEN Jingjing 

Cite this article as: Lü Q, Zhou RZ, Li YD, et al. The value of Gd-EOB-DTPA enhanced MRI signal intensity in evaluating liver function. Chin J Magn Reson Imaging, 2019, 10(10): 752-756. DOI:10.12015/issn.1674-8034.2019.10.007.


[Abstract] Objective: To explore the feasibility of Gd-EOB-DTPA enhanced MRI signal intensity in evaluating liver function by analyzing the changes of relative enhancement (RE) and the ratio of liver to portal vein enhancement (LPC) in Gd-EOB-DTPA enhanced MRI.Materials and Methods: Date of 129 patients with Gd-EOB-DTPA enhanced MRI was collected. Measured and calculated RE values and LPC values. One-way ANOVA was used to compare RE and LPC values in the control group, Child-Pugh A group, Child-Pugh B group, and Child-Pugh C group. ROC curve was performed to analyze the diagnostic efficiency of RE and LPC values in evaluating liver function.Results: The mean values of RE are respectively 2.14±0.31, 1.86±0.30, 1.44±0.23, 1.18±0.18 in the control group, Child-Pugh A group, Child- Pugh B group, and Child-Pugh C group. The mean values of LPC are respectively 2.06±0.33, 1.62±0.19, 1.21±0.17, 0.93±0.12 in the control group, Child-Pugh A group, Child-Pugh B group, and Child-Pugh C group. There were significant differences in RE and LPC values between the control group and different Child-Pugh grading groups (P<0.05). There were significant differences in RE and LPC between any two groups (P<0.05). The area under the curve of RE and LPC was 0.762 and 0.892 in the control group and Child-Pugh A group respectively. The area under the curve of RE and LPC was 0.880 and 0.942 in Child-Pugh A group and B group respectively. The area under the curve of RE and LPC was 0.817 and 0.920 in Child-Pugh B group and C group respectively. The area under the curve of RE and LPC was 0.936 and 0.975 in the control group+Child-Pugh A group and Child-Pugh B+C group respectively.Conclusions: Gd-EOB-DTPA enhanced MRI signal intensity is helpful to evaluate liver function and to differentiate the degree of liver function impairment.
[Keywords] liver function；magnetic resonance imaging；Gd-EOB-DTPA；signal intensity

LÜ Qian Department of Radiology, Affiliated Hospital of Qingdao University, Qingdao 266003, China

ZHOU Ruizhi Department of Radiology, Affiliated Hospital of Qingdao University, Qingdao 266003, China

LI Yingduan Department of Radiology, Affiliated Hospital of Qingdao University, Qingdao 266003, China

HUA Hui Department of Thyroid Surgery, Affiliated Hospital of Qingdao University, Qingdao 266003, China

PANG Jing Department of Radiology, Affiliated Hospital of Qingdao University, Qingdao 266003, China

CHEN Jingjing * Department of Radiology, Affiliated Hospital of Qingdao University, Qingdao 266003, China

*Correspondence to: Chen JJ, E-mail: chenjingjingsky@126.com

Conflicts of interest   None.

Received  2019-04-04
DOI: 10.12015/issn.1674-8034.2019.10.007
Cite this article as: Lü Q, Zhou RZ, Li YD, et al. The value of Gd-EOB-DTPA enhanced MRI signal intensity in evaluating liver function. Chin J Magn Reson Imaging, 2019, 10(10): 752-756. DOI:10.12015/issn.1674-8034.2019.10.007.

[1]
Yang T, Zhang J, Lu JH, et al. Risk factors influencing postoperative outcomes of major hepatic resection of hepatocellular carcinoma for patients with underlying liver diseases. World J Surg, 2011, 35(9): 2073-2082.
[2]
Okada M, Ishii K, Numata K, et al. Can the biliary enhancement of Gd- EOB-DTPA predict the degree of liver function?. Hepatobiliary Pancreat Dis Int, 2012, 11(3): 307-313.
[3]
梁明龙，张琳，张久权，等．利用钆塞酸二钠增强MR评估肝脏储备功能.中华放射学杂志, 2013, 47(6): 522-525.
[4]
徐佳，王萱，金征宇．增强MRI定量评价肝纤维化及肝功能的研究进展．中华放射学杂志, 2016, 50(12): 994-996.
[5]
Imura S, Shimada M, Utsunomiya T. Recent advances in estimating hepatic functional reserve in patients with chronic liver damage. Hepatol Res, 2015, 45(1): 10-19.
[6]
Jaw TS, Chen SH, Wang YM, et al. Comparison of Gd-Bz-TTDA, Gd- EOB-DTPA, and Gd-BOPTA for dynamic MR imaging of the liver in rat models. Kaohsiung J Med Sci, 2012, 28(3): 130-137.
[7]
Lagadec M, Doblas S, Giraudeau C, et al. Advanced fibrosis: Correlation between pharmacokinetic parameters at dynamic gadoxetate-enhanced MR imaging and hepatocyte organic anion transporter expression in rat liver. Radiology, 2015, 274(2): 379-386.
[8]
韩丹，张洁，靳二虎，等.钆塞酸二钠增强MRI评价原发性胆汁性胆管炎患者肝功能的可行性研究．磁共振成像, 2017, 8(5): 337-342.
[9]
Motosugi U, Ichikawa T, Sou H, et al. Liver parenchymal enhancement of hepatocyte-phase images in Gd-EOB-DTPA-enhanced MR imaging: which biological markers of the liver function affect the enhancement?. J Magn Reson Imaging, 2009, 30(5): 1042-1046.
[10]
朱望舒，石思雅，杨绮华，等.钆塞酸二钠增强MRI对肝功能评估价值的血清学对照研究．磁共振成像, 2017, 8(11): 834-838.
[11]
Lee S, Choi D, Jeong WK. Hepatic enhancement of Gd-EOB-DTPA- enhanced 3 Tesla MR imaging: Assessing severity of liver cirrhosis. J Magn Reson Imaging, 2016, 44(5): 1339-1345.
[12]
Verloh N, Utpatel K, Haimerl M, et al. Liver fibrosis and Gd-EOB-DTPA-enhanced MRI: A histopathologic correlation. Sci Rep, 2015, 5: 15408.
[13]
Verloh N, Haimerl M, Zeman F, et al. Assessing liver function by liver enhancement during the hepatobiliary phase with Gd-EOB-DTPA- enhanced MRI at 3 Tesla. Eur Radiol, 2014, 24(5): 1013-1019.
[14]
Lee NK, Kim S, Kim GH, et al. Significance of the delayed hyperintense portal vein sign in the hepatobiliary phase MRI obtained with Gd-EOB-DTPA. J Magn Reson Imaging, 2012, 36(3): 678-685.
[15]
Matoori S, Froehlich JM, Breitenstein S, et al. Age dependence of spleen- and muscle-corrected hepatic signal enhancement on hepatobiliary phase gadoxetate MRI. Eur Radiol, 2016, 26(6): 1889-1894.
[16]
de Graaf W, Bennink RJ, Vetelainen R, et al. Nuclear imaging techniques for the assessment of hepatic function in liver surgery and transplantation. J Nucl Med, 2010, 51(5): 742-752.
[17]
Tamada T, Ito K, Sone T, et al. Gd-EOB-DTPA enhanced MR imaging: evaluation of biliary and renal excretion in normal and cirrhotic livers. Eur J Radiol, 2011, 80(3): e207-e211.
[18]
Takatsu Y, Kobayashi S, Miyati T, et al. A novel method for evaluating enhancement using gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid in the hepatobiliary phase of magnetic resonance imaging. Clin Imaging, 2016, 40(6): 1112-1117.
[19]
汪小，张卫国，冯婷婷，等．采用钆塞酸二钠增强MRI肝胆期门静脉信号强度评价肝脏功能的临床价值．中华放射学杂志, 2018, 52(2): 108-112.

PREV Diffusion tensor imaging for the development of neonatal brain myelin
NEXT Value of PDW-SPAIR in visual assessment of active lesions in patients with rheumatoid arthritis
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn