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• Technical Article •
Detection of microstructural developmental changes in cerebral gray matter nuclei by diffusion kurtosis imaging
SUN Qinli  LI Xianjun  LI Mengxuan  SHANG Jin  LIU Zhe  JIN Chao  ZHANG Yuli  LIU Congcong  YU Bolang  YANG Jian 

Cite this article as: Sun QL, Li XJ, Li MX, et al. Detection of microstructural developmental changes in cerebral gray matter nuclei by diffusion kurtosis imaging. Chin J Magn Reson Imaging, 2019, 10(10): 774-778. DOI:10.12015/issn.1674-8034.2019.10.011.


[Abstract] Objective: To explore the significance of diffusion kurtosis imaging (DKI) technique in the study of gray matter development, this work investigated the differences of diffusion tensor metrics and kurtosis metrics in detecting the microstructural developmental changes from neonates to adults on the cerebral gray matter nuclei.Materials and Methods: Twenty-two term neonates (postmenstrual age of 39—44 weeks) and 22 adults (age of 18—26 years) were included. DKI was performed in a 3.0 T scanner with the following variables: b values=0, 500, 1000, 2000 and 2500 s/mm2; 18 gradient directions per nonzero b value. Fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), radial diffusivity (RD), mean kurtosis (MK), axial kurtosis (AK) and radial kurtosis (RK) were calculated by using the DKI model. Four regions of interest (ROIs) of the cerebral gray matter nuclei, including thalamus, putamen, globus pallidus and caudate nucleus, were selected based on the brain atlas.Results: Compared with neonates, FA, MK, AK and RK increased in the four adults gray matter nuclei, while MD, AD and RD reduced. Except AD in thalamus (P=0.944), the mean values of FA, MD, AD, RD, MK, AK and RK in four GM nuclei were statistically different between neonates and adults (P<0.05). The relative change ratios of MK, AK and RK ranged from 82.86% to 210.81%, while those of FA, MD, AD and RD ranged just from 1.45% to 70.59%.Conclusions: The change rates of kurtosis metrics on the gray matter nuclei between neonates and adults were higher than those of diffusion tensor metrics, which suggested that the sensitivity of kurtosis metrics was higher on the detection of microstructural changes on the gray matter nuclei. DKI has the potential to explore the developmental change of gray matter.
[Keywords] magnetic resonance imaging；diffusion tensor imaging；diffusion kurtosis imaging；cerebral gray matter nuclei

SUN Qinli Department of Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061; Department of Biomedical Engineering, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710054, China

LI Xianjun Department of Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061

LI Mengxuan Department of Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061

SHANG Jin Department of Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061

LIU Zhe Department of Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061

JIN Chao Department of Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061

ZHANG Yuli Department of Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061

LIU Congcong Department of Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061

YU Bolang Department of Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061

YANG Jian * Department of Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061; Department of Biomedical Engineering, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710054, China

*Correspondence to: Yang J, E-mail: yj1118@mail.xjtu.edu.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Key Research and Development Program of China No.2016YFC0100300 National Natural Science Foundation of China No. 81471631, 81771810 and 81171317 2011 New Century Excellent Talent Support Plan of the Ministry of Education, China No. NCET-11-0438 Shaanxi Provincial Natural Science Foundation for Youths of China No. 2019JQ-198 and 2017JQ8005 Clinical Research Award of the First Affiliated Hospital of Xi’an Jiaotong University No. XJTU1AF-CRF-2015-004 the Youth Innovation Fund of the First Affiliated Hospital of Xi’an Jiaotong University No. 2011YK.19
Received  2019-05-14
DOI: 10.12015/issn.1674-8034.2019.10.011
Cite this article as: Sun QL, Li XJ, Li MX, et al. Detection of microstructural developmental changes in cerebral gray matter nuclei by diffusion kurtosis imaging. Chin J Magn Reson Imaging, 2019, 10(10): 774-778. DOI:10.12015/issn.1674-8034.2019.10.011.

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