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• Clinical Article •
The relationship between brain injury and cognitive impairment in type 2 diabetes mellitus patients with cerebral small vessel disease
HUANG Mingming  YANG Liming  WEI Shasha  CAI Xi  ZHANG Miao  HE Juan  ZHENG Jing  LI Xiaobao  YU Hui 

Cite this article as: Huang MM, Yang LM, Wei SS, et al. The relationship between brain injury and cognitive impairment in type 2 diabetes mellitus patients with cerebral small vessel disease. Chin J Magn Reson Imaging, 2019, 10(11): 807-812. DOI:10.12015/issn.1674-8034.2019.11.002.


[Abstract] Objective: To investigate the relationship between brain injury and cognitive impairment in type 2 diabetes mellitus (T2DM) patients with cerebral small vessel disease (CSVD).Materials and Methods: Eighteen T2DM patients with CSVD (T2DM group) and 18 matched healthy subjects (control group) were collected and underwent 3D T1 weighted imaging (3D T1WI) and diffusion tensor imaging (DTI) scans, Mini Mental State Exam (MMSE) and Montreal Cognitive Assessment (MoCA) were also performed to evaluate their cognitive status.Results: From the morphometric analysis, compared to the control groups, significantly atrophy and thinner cortical thickness were found in temporal and occipital lobe, and thinner cortical thickness were found in left middle frontal, frontal pole and right insula in T2DM patients. Besides, the reduction of FA value was found in frontal, temporal, occipital, corpus callosum, cingulum, insula, thalamus and hippocampus, and almost the white matter in cerebral were injured, which were accompanied with the increasing of λ∥, λ⊥ and ADC values. Moreover, significantly positive correlation between MoCA scores and FA value in bilateral superior longitudinal fasciculus.Visual spatial execution ability scores and FA value in left anterior thalamic radiation; memory scores and FA value in left cingulum (hippocampus).Conclusions: DTI provides a more effective way to investigate the brain microstructure injury caused by T2DM with CSVD than commonly 3D T1. It can further help to provide early biomarkers for diagnosis of cognitive impairment in T2DM patients with CSVD.
[Keywords] diabetes mellitus；cerebrovascular disorders；cognition disorders；brain injuries

HUANG Mingming Department of Radiology, Affiliated Hospital of Guizhou Medical University , Guiyang, 550004, China

YANG Liming Department of Radiology, Affiliated Hospital of Guizhou Medical University , Guiyang, 550004, China

WEI Shasha Department of Radiology, Affiliated Hospital of Guizhou Medical University , Guiyang, 550004, China

CAI Xi Department of Radiology, Affiliated Hospital of Guizhou Medical University , Guiyang, 550004, China

ZHANG Miao Department of Endocrinology, Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, China

HE Juan Department of Endocrinology, Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, China

ZHENG Jing Department of Endocrinology, Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, China

LI Xiaobao Department of Radiology, Affiliated Hospital of Guizhou Medical University , Guiyang, 550004, China

YU Hui * Department of Radiology, Affiliated Hospital of Guizhou Medical University , Guiyang, 550004, China

*Correspondence to: Yu H, E-mail: 331693861@qq.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work is supported by grants from the Natural Science Foundation of China No. 81560281 Science and Technology Department of Guizhou Province No. LG 2012-024, LH 2014-7121 Higher Education Research Center of Guizhou Provincial No. qianjiaohe KY 2016- 012
Received  2019-06-10
DOI: 10.12015/issn.1674-8034.2019.11.002
Cite this article as: Huang MM, Yang LM, Wei SS, et al. The relationship between brain injury and cognitive impairment in type 2 diabetes mellitus patients with cerebral small vessel disease. Chin J Magn Reson Imaging, 2019, 10(11): 807-812. DOI:10.12015/issn.1674-8034.2019.11.002.

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