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• Technical Article •
Effect of DRD4 receptor-616 C/G polymorphism on white matter microstructure in normal adolescents, a MRI study using neurite orientation dispersion and density imaging technique
LI Xiaoyang  HUANG Mingzhu  ZHANG Xu  YU Bing 

Cite this article as: Li XY, Huang MZ, Zhang X, et al. Effect of DRD4 receptor-616 C/G polymorphism on white matter microstructure in normal adolescents, a MRI study using neurite orientation dispersion and density imaging technique. Chin J Magn Reson Imaging, 2019, 10(11): 840-844. DOI:10.12015/issn.1674-8034.2019.11.009.


[Abstract] Objective: To assess the effect of-616 C/G single nucleotide polymorphism (SNP) in the dopamine D4 receptor (DRD4) promoter rs747302 on white matter microstructure in normal adolescents using neurite orientation dispersionand density imaging (NODDI) methodology.Materials and Methods: Genomic and NODDI imaging data were obtained from 179 healthy adolescents. SNP of rs747302 was genotyped. NODDI imaging data were collected uning a 3.0 tesla MR scanner, neurite density index (NDI) and orientation dispersion index (ODI) were calculated and compared between different genotype (C/G) using TBSS software.Results: Differences of NDI and ODI between genotype were found in anterior thalamic radiation (ATR), C allele carriers of rs747302 exhibited lower NDI and high ODI in ATR.Conclusions: Among male adolescents, C-allele carriers of rs747302 were associated lower NDI and high ODI in ATR.
[Keywords] adolescence；neurite orientation dispersionand density imaging；single nucleotide polymorphism；white matter；magnetic resonance imaging

LI Xiaoyang Department of Radiology, Shengjing Hospital of China Medical University, Shenyang 110001, China

HUANG Mingzhu Department of Radiology, Shengjing Hospital of China Medical University, Shenyang 110001, China

ZHANG Xu Department of Radiology, Shengjing Hospital of China Medical University, Shenyang 110001, China

YU Bing * Department of Radiology, Shengjing Hospital of China Medical University, Shenyang 110001, China

*Correspondence to: Yu B, E-mail: dr.yubing@vip.163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was supported by the Natural Science Foundation of China No. 81871336, 81301204, and 81541058
Received  2019-07-18
DOI: 10.12015/issn.1674-8034.2019.11.009
Cite this article as: Li XY, Huang MZ, Zhang X, et al. Effect of DRD4 receptor-616 C/G polymorphism on white matter microstructure in normal adolescents, a MRI study using neurite orientation dispersion and density imaging technique. Chin J Magn Reson Imaging, 2019, 10(11): 840-844. DOI:10.12015/issn.1674-8034.2019.11.009.

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