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Advances in neuroimaging of inflammatory bowel disease
CHEN Chen  HE Jian  ZHANG Bing 

Cite this article as: Chen C, He J, Zhang B. Advances in neuroimaging of inflammatory bowel disease. Chin J Magn Reson Imaging, 2019, 10(11): 877-880. DOI:10.12015/issn.1674-8034.2019.11.019.


[Abstract] Inflammatory bowel disease is a kind of chronic and recurrent intestinal inflammatory disease with a tendency of lifelong recurrence, which has a variety etiologies. In addition to the known extraintestinal symptoms, such as arthritis and iritis, some studies have pointed out that inflammatory bowel disease patients also have nervous system involvement, and this may be another extraintestinal manifestation. Preliminary research findings have been obtained in the study of brain structure and function in patients with inflammatory bowel disease by using magnetic resonance imaging (MRI). Therefore, the purpose of this article is to review the current research progress in the field of neuroimaging of inflammatory bowel disease.
[Keywords] inflammatory bowel disease;brain-gut axis;structural magnetic resonance;magnetic resonance imaging;magnetic resonance spectroscopy

CHEN Chen Department of Radiology, the Affiliated Drum Towel Hospital, Medical School of Nanjing University, Nanjing 210008, China

HE Jian Department of Radiology, the Affiliated Drum Towel Hospital, Medical School of Nanjing University, Nanjing 210008, China

ZHANG Bing * Department of Radiology, the Affiliated Drum Towel Hospital, Medical School of Nanjing University, Nanjing 210008, China

*Corresponding to: Zhang B, E-mail: zhangbing_nanjing@nju.edu.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS  This article is supported by the National Natural Science Found No. 81720108022
Received  2019-08-09
DOI: 10.12015/issn.1674-8034.2019.11.019
Cite this article as: Chen C, He J, Zhang B. Advances in neuroimaging of inflammatory bowel disease. Chin J Magn Reson Imaging, 2019, 10(11): 877-880. DOI:10.12015/issn.1674-8034.2019.11.019.

[1]
Ng SC, Shi HY, Hamidi N, et al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet, 2017, 390(10114): 2769-2778.
[2]
Mawdsley JE, Rampton DS. Psychological stress in IBD: new insights into pathogenic and therapeutic implications. Gut, 2005, 54(10): 1481-1491.
[3]
Bonaz BL, Bernstein CN. Brain-gut interactions in inflammatory bowel disease. Gastroenterology, 2013, 144(1): 36-49.
[4]
Pellissier S, Dantzer C, Mondillon L, et al. Relationship between vagal tone, cortisol, TNF-alpha, epinephrine and negative affects in Crohn's disease and irritable bowel syndrome. PLoS One, 2014, 9(9): e105328.
[5]
Bonaz B, Sinniger V, Hoffmann D, et al. Chronic vagus nerve stimulation in Crohn's disease: a 6-month follow-up pilot study. Neurogastroenterol Motil, 2016, 28(6): 948-953.
[6]
Tillisch K, Labus JS. Advances in imaging the brain-gut axis: functional gastrointestinal disorders. Gastroenterology, 2011, 140(2): 407-411.
[7]
Agostini A, Benuzzi F, Filippini N, et al. New insights into the brain involvement in patients with Crohn's disease: a voxel-based morphometry study. Neurogastroenterol Motil, 2013, 25(2): 147-e82.
[8]
Bao CH, Liu P, Liu HR, et al. Alterations in brain grey matter structures in patients with crohn's disease and their correlation with psychological distress. J Crohns Colitis, 2015, 9(7): 532-540.
[9]
Bao C, Liu P, Shi Y, et al. Differences in brain gray matter volume in patients with Crohn' s disease with and without abdominal pain. Oncotarget, 2017, 8(55): 93624-93632.
[10]
PW S, PE G, RG G. Diffusion-weighted MR imaging of the brain. Radiology, 2000, 217(2): 331-345.
[11]
Zikou AK, Kosmidou M, Astrakas LG, et al. Brain involvement in patients with inflammatory bowel disease: a voxel-based morphometry and diffusion tensor imaging study. Eur Radiol, 2014, 24(10): 2499-2506.
[12]
Agostini A, Filippini N, Benuzzi F, et al. Functional magnetic resonance imaging study reveals differences in the habituation to psychological stress in patients with Crohn's disease versus healthy controls. J Behav Med. 2013, 36(5): 477-487.
[13]
Agostini A, Filippini N, Cevolani D, et al. Brain functional changes in patients with ulcerative colitis: a functional magnetic resonance imaging study on emotional processing. Inflamm Bowel Dis, 2011, 17(8): 1769-1777.
[14]
Rubio A, Pellissier S, Van Oudenhove L, et al. Brain responses to uncertainty about upcoming rectal discomfort in quiescent Crohn's disease: a fMRI study. Neurogastroenterol Motil, 2016, 28(9): 1419-1432.
[15]
Zang Y, Jiang T, Lu Y, et al. Regional homogeneity approach to fMRI data analysis. Neuroimage, 2004, 22(1): 394-400.
[16]
Bao C, Liu P, Liu H, et al. Different brain responses to electroacupuncture and moxibustion treatment in patients with Crohn's disease. Sci Rep, 2016, 6: 36636.
[17]
Bao CH, Liu P, Liu HR, et al. Differences in regional homogeneity between patients with Crohn's disease with and without abdominal pain revealed by resting-state functional magnetic resonance imaging. Pain, 2016, 157(5): 1037-1044.
[18]
Bao C, Liu P, Liu H, et al. Difference in regional neural fluctuations and functional connectivity in Crohn's disease: a resting-state functional MRI study. Brain Imaging Behav, 2018, 12(6): 1795-1803.
[19]
Bao C, Wang D, Liu P, et al. Effect of electro-acupuncture and moxibustion on brain connectivity in patients with Crohn's disease: a resting-state fMRI study. Front Hum Neurosci, 2017, 11: 559.
[20]
Thomann AK, Griebe M, Thomann PA, et al. Intrinsic neural network dysfunction in quiescent Crohn's disease. Sci Rep, 2017, 7(1): 11579.
[21]
Fox MD, Raichle ME. Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Nat Rev Neurosci, 2007, 8(9): 700-711.
[22]
Lv K, Song W, Tang R, et al. Neurotransmitter alterations in the anterior cingulate cortex in Crohn's disease patients with abdominal pain: a preliminary MR spectroscopy study. Neuroimage Clin, 2018, 20: 793-799.
[23]
Mullins PG, Rowland LM, Jung RE, et al. A novel technique to study the brain's response to pain: proton magnetic resonance spectroscopy. Neuroimage, 2005, 26(2): 642-646.
[24]
Ito T, Tanaka-Mizuno S, Iwashita N, et al. Proton magnetic resonance spectroscopy assessment of metabolite status of the anterior cingulate cortex in chronic pain patients and healthy controls. J Pain Res, 2017, 10: 287-293.
[25]
Filpa V, Moro E, Protasoni M, et al. Role of glutamatergic neurotransmission in the enteric nervous system and brain-gut axis in health and disease. Neuropharmacology, 2016, 111: 14-33.

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