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• Clinical Article •
The study of regional homogeneity and voxel-mirrored homotopic connectivity of minimal hepatic encephalopathy disease at resting-state fMRI
GAO Yuling  WANG Shuaiwen  TIAN Shuishui  SHE Yingxia  XU Yongsheng  GUO Shunlin  LEI Junqiang 

Cite this article as: Gao YL, Wang SW, Tian SS, et al. The study of regional homogeneity and voxel-mirrored homotopic connectivity of minimal hepatic encephalopathy disease at resting-state fMRI. Chin J Magn Reson Imaging, 2019, 10(12): 885-889. DOI:10.12015/issn.1674-8034.2019.12.002.


[Abstract] Objective: Resting brain function MRI technique was used to investigate the abnormal changes of regional cerebral functional activity, functional connection between symmetrical alleles in bilateral cerebral hemispheres and synchronization of neuroactivity in patients with minimal hepatic encephalopathy (MHE) in resting state. In order to provide a reliable imaging basis for the occurrence and development of MHE.Materials and Methods: Bring into 20 patients (13 males and 7 females, mean age 51.6±4.7 years) with MHE diagnosed by neuropsychological test in our hospital were enrolled in this study. The average age was 48.2±5.5 years old, and 20 cases (14 males and 6 females) were included in the healthy control group. Structural imaging (T1-MPRAGE) and blood oxygen level dependent functional magnetic resonance imaging (BOLD-fMRI) were performed with Siemens 3.0 T MR in both groups. The scanned images of all subjects were preprocessed and analyzed by regional homogeneity (ReHo) and voxel-mirrored homotopic connectivity (VMHC) using the statistical tools of DPASF 4.3 software package on Matlab 2013b platform. Statistical analysis was used to compare the difference of regional brain function between MHE patients and healthy controls at rest and the synergetic changes between bilateral cerebral hemispheric allelic voxels.Results: Compared with HC group, the brain areas with decreased ReHo value in MHE group included superior frontal gyrus and middle frontal gyrus, and those in MHE group included bilateral superior frontal gyrus and medial frontal gyrus. Middle temporal gyrus, lingual gyrus, anterior cingulate gyrus, cerebellar hemispherical, tegmental and pons (voxel level, P<0.05, corrected by FDR).Conclusions: In resting state, ReHo and VMHC can be used to analyze the changes of brain network function in patients with MHE in a more comprehensive way. At the same time, it provides a theoretical basis for explaining the clinical manifestations, pathophysiological changes and pathogenesis of MHE.
[Keywords] hepatic encephalopathy；functional magnetic resonance imaging；resting state；regional homogeneity；voxel-mirrored homotopic connectivity

GAO Yuling The First School of Clinical Medical of Lanzhou University, Lanzhou 730000, China; Department of Radiology, the First Hospital of Lanzhou University, Lanzhou 730000, China

WANG Shuaiwen Department of Radiology, the First Hospital of Lanzhou University, Lanzhou 730000, China

TIAN Shuishui The First School of Clinical Medical of Lanzhou University, Lanzhou 730000, China; Department of Radiology, the First Hospital of Lanzhou University, Lanzhou 730000, China

SHE Yingxia Department of Radiology, the Second Hospital of Lanzhou University, Lanzhou 730000, China

XU Yongsheng The First School of Clinical Medical of Lanzhou University, Lanzhou 730000, China; Department of Radiology, the First Hospital of Lanzhou University, Lanzhou 730000, China

GUO Shunlin Department of Radiology, the First Hospital of Lanzhou University, Lanzhou 730000, China

LEI Junqiang * Department of Radiology, the First Hospital of Lanzhou University, Lanzhou 730000, China

*Correspondence to: Lei JQ, E-mail: leijq2011@126.com

Conflicts of interest   None.

Received  2019-03-09
DOI: 10.12015/issn.1674-8034.2019.12.002
Cite this article as: Gao YL, Wang SW, Tian SS, et al. The study of regional homogeneity and voxel-mirrored homotopic connectivity of minimal hepatic encephalopathy disease at resting-state fMRI. Chin J Magn Reson Imaging, 2019, 10(12): 885-889. DOI:10.12015/issn.1674-8034.2019.12.002.

[1]
中华医学会肝病学分会, 中华医学会消化病学分会．中国肝性脑病诊治共识意见（2013年，重庆)．中国医学前沿杂志（电子版), 2014, 6(2): 81-93.
[2]
Liao LM, Zhou LX, Le HB, et al. Spatial working memory dysfunction in minimal hepatic encephalopathy: An ethology and BOLD-fMRI study. Brain Res, 2012, 1445(2): 62-72.
[3]
Jao T, Schroter M, Chen CL, et al. Functional brain network changes associated with clinical and biochemical measures of the severity of hepatic encephalopathy. Neuro Image, 2015, 122(15): 332-344.
[4]
周治明，赵建农，郭大静，等．轻微型肝性脑病神经元自发活动异常功能磁共振研究．第三军医大学学报, 2013, 35(24): 2697-2704.
[5]
Kendall M, Gibbons JD. Rank correlation methods. Oxford: Oxford University Press, 1990.
[6]
Xiong J, Parsons LM, Gao JH, et al. Interregional connectivity to primary motor cortex revealed using MRI resting state images. Hum Brain Map, 1999, 8(2-3): 151-156.
[7]
Zuo XN, Kelly C, Martino AD, et al. Growing together and growing apart: regional and sex differences in the lifespan developmental trajectories of functional homotopy. J Neuroscience, 2010, 30(45): 15034-15043.
[8]
Stark DE, Margulies DS, Shehzad ZE, et al. Regional variation in interhemispheric coordination of intrinsic hemodynamic fluctuations. J Neuroscience, 2008, 28(51): 13754-13764.
[9]
Tekin S, Cummings JL. Frontal-subcortical neuronal circuits and clinical neuropsychiatry：an update. J Psychosom Res, 2002, 53(2): 647-654.
[10]
吴媛，郭大静，赵建农，等．轻微型肝性脑病患者静息态脑功能局部一致性研究.重庆医科大学学报, 2014, 39(4): 466-499.
[11]
Ni L, Qi RF, Zhang LJ, et al. Altered regional homogeneity in the development of minimal hepatic encephalopathy：a resting-state functional MRI study. PLoS One，2012, 7(7): e42016.
[12]
Raichle ME, Macleod AM, Snyder AZ, et al. A default mode of brain function. Proc Natl Acad Sci USA, 2001, 98(2): 676-682.
[13]
Gilbert SJ, Williamson ID, Dumontheil I, et al. Distinct regions of medial rostral prefrontal cortex supporting social and nonsocial functions. Soc Cogn Affect Neurosci, 2007, 2(3): 217-226.
[14]
Wandell BA, Dumoulin SO, Brewer AA. Visual field maps in human cortex. Neuron, 2007, 56(2): 366-383.
[15]
Qi R, Xu Q, Zhang LJ, et al. Structural and functional abnormalities of default mode network in minimal hepatic encephalopathy: A study combining DTI and fMRI. PLoS One, 2012, 7(7): e41376.
[16]
Huang CY, Lee CY, Huang HW, et al. Number of sense effects of Chinese disyllabic compounds in the two hemispheres. Brain & Language, 2011, 119(2): 99-109.
[17]
Kobayashi Y, Amaral DG. Macaque monkey retrosplenial cortex: II. Cortical afferents. J Comp Neurol, 2010, 502(5): 810-833.
[18]
耿艳，张红红，王鲁宁，等．小脑认知功能研究进展．中华老年医学杂志, 2014, 33(3): 330-332.
[19]
Maria G, Leggio, Francesca R, et al. The neuropsychological profile of cerebellar damage: The sequencing hypothesis. Cortex, 2011, 47(1): 137-144.
[20]
王波，胡乐明．事件相关电位P300对亚临床肝性脑病诊断价值探讨.中华消化杂志, 2002, 22(6): 375-375.

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