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• Clinical Article •
The value of FLAIR vascular hyperintensity in evaluating the outcome of stroke after non-reperfusion therapy
HUANG Hongtao  JIN Mingxu  PENG Mingyang  YIN Xindao  WANG Wei 

Cite this article as: Huang HT, Jin MX, Peng MY, et al. The value of FLAIR vascular hyperintensity in evaluating the outcome of stroke after non-reperfusion therapy. Chin J Magn Reson Imaging, 2020, 11(1): 6-10. DOI:10.12015/issn.1674-8034.2020.01.002.


[Abstract] Objective: To investigate the prognostic value of fluid-attenuated inversion recovery vascular hyperintensity (FVH) in outcome of stroke patients with mild symptoms and middle cerebral artery occlusion after non-reperfusion therapy.Materials and Methods: The stroke patients with mild symptoms [National Institute of Health stroke scale (NIHSS)≤5 score] who were admitted to our hospital from January 2017 to March 2019 were rolled prospectively. All patients underwent magnetic resonance imaging (MRI) before therapy and were diagnosed as middle cerebral artery occlusion in MR angiography (MRA). According to the presence or absence of FVH, FVH was divided into two groups: FVH (-) and FVH (+). Diffusion weighted imaging (DWI), infarct volume, 3-month functional outcome (mRS score) and clinical data were collected. Statistical analysis was performed to evaluate the prognostic value of FVH in outcome of stroke patients with mild symptoms and middle cerebral artery occlusion after non-reperfusion therapy.Results: In patients with non-reperfusion therapy (n=48), the FVH-DWI mismatch rate (23.81%), the poor outcome (14.29%) in FVH (-) group were lower than those in FVH (+) group (66.67%; 51.85%), and the difference was significant (t=8694, P=0.004; t=7.288, P=0.014). Compared with the good outcome group, the poor outcome group had lower FVH-DWI mismatch rate (23.81% vs 61.29%), larger DWI infarct volume (6.60±1.11 vs 4.43±2.20) and higher FVH (+) rate (82.35% vs 41.94%), there were significant difference (t=6.273, P=0.017; t=4.447, P=0.000; t=7.288, P=0.014). Logistic regression analysis showed that DWI infarct volume [OR (95% CI)]: 0.327 [(0.154-0.698), P=0.004], FVH [OR (95%CI)]: 6.462 [(1.536—27.179), P=0.011] and FVH-DWI mismatch [OR (95% CI)]: 0.099 [(0.025-0.389), P=0.001] were independently factors in outcome of stroke patients with non-reperfusion therapy.Conclusions: For stroke patients with mild symptoms and middle cerebral artery occlusion with non-reperfusion therapy, those with prominent FVH are more likely to have poor outcome than those without prominent FVH.
[Keywords] stroke；magnetic resonance imaging；prognosis；fluid-attenuated inversion recovery vascular hyperintensity

HUANG Hongtao Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China

JIN Mingxu Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China

PENG Mingyang Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China

YIN Xindao Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China

WANG Wei Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China

*Correspondence to: Wang W, E-mail: vikeywang@sina.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This article is supported by the Jiangsu Science and Technology Development Project No. BE2017614
Received  2019-08-19
Accepted  2019-11-21
DOI: 10.12015/issn.1674-8034.2020.01.002
Cite this article as: Huang HT, Jin MX, Peng MY, et al. The value of FLAIR vascular hyperintensity in evaluating the outcome of stroke after non-reperfusion therapy. Chin J Magn Reson Imaging, 2020, 11(1): 6-10. DOI:10.12015/issn.1674-8034.2020.01.002.

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