Share：
Share this content in WeChat
X
[Chinese][PDF]86388
• Clinical Article •
Prognostic value of combined PET and MRI volume analysis in brainstem glioma
WANG Kai  ZHAO Xiaobin  LI Deling  WU Yuliang  QIAO Zhen  ZHANG Liwei  AI Lin 

Cite this article as: Wang K, Zhao XB, Li DL, et al. Prognostic value of combined PET and MRI volume analysis in brainstem glioma. Chin J Magn Reson Imaging, 2020, 11(1): 11-15. DOI:10.12015/issn.1674-8034.2020.01.003.


[Abstract] Objective: To investigate the prognostic value of the 3-dimensional volumetric data assessed using MRI and 11C-labeled methionine (MET) PET combined with the presence of oligodendroglial component in patients with brainstem gliomas (BSG).Materials and Methods: Baseline pre-surgical brain 11C-MET PET and MRI scans were prospectively performed in 41 patients with BSG between March 2015 and July 2016, and all patients underwent neurosurgery in our institute. Three-dimensional volumetric data of contrast enhancement and metabolic tumor volume (MTV) was calculated by using contrast-enhanced T1 weighted images and PET images on post-processing station automatically, and then the enhancement volume (EV)-to-MTV ratio was calculated. The Kaplan-Meier method and Cox regression model were used to identify prognostic factors for overall survival.Results: BSG patients with EV-to-MTV ratios ≤50% demonstrated a significantly better survival at 3 months (P=0.015) and 12 months (P=0.018) following tumor resection compared to those with EV-to-MTV ratios> 50%. Furthermore, the EV (P=0.036), EV-to-MTV ratio (P=0.018), tumor grade (P=0.003), and adjuvant therapy (P= 0.003) were significant prognostic factors for overall survival in BSG patients.Conclusions: Patients with a lower EV-to-MTV ratio were more likely to achieve better prognosis than those with a higher ratio. In addition, this ratio might add more indicative prognostic value compared to single imaging index or pathological information.
[Keywords] glioma；brain stem；magnetic resonance imaging；positron emission tomography computed tomography；prognosis

WANG Kai Department of Nuclear Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing 100160, China

ZHAO Xiaobin Department of Nuclear Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing 100160, China

LI Deling Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100160, China

WU Yuliang Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100160, China

QIAO Zhen Department of Nuclear Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing 100160, China

ZHANG Liwei Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100160, China

AI Lin* Department of Nuclear Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing 100160, China

*Correspondence to: Ai L, E-mail: ailin@bjtth.org

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was supported by Beijing Special Program of the Talents NO. 2017000021469G278
Received  2019-02-23
Accepted  2019-11-21
DOI: 10.12015/issn.1674-8034.2020.01.003
Cite this article as: Wang K, Zhao XB, Li DL, et al. Prognostic value of combined PET and MRI volume analysis in brainstem glioma. Chin J Magn Reson Imaging, 2020, 11(1): 11-15. DOI:10.12015/issn.1674-8034.2020.01.003.

[1]
Donaldson SS, Laningham F, and Fisher PG. Advances toward an understanding of brainstem gliomas. J Clin Oncol, 2006, 24(8): 1266-1272.
[2]
Frazier JL, Lee J, Thomale UW, et al. Treatment of diffuse intrinsic brainstem gliomas: failed approaches and future strategies. J Neurosurg Pediatr, 2009, 3(4): 259-269.
[3]
Hennika T, Becher OJ. Diffuse intrinsic pontine glioma: time for cautious optimism. J Child Neurol, 2016, 31(12): 1377-1385.
[4]
梁甜甜，张辉，王效春，等．术前动态磁敏感对比增强MR灌注加权成像在脑胶质瘤预后评估中的价值研究．磁共振成像, 2018, 9(6): 406-410.
[5]
南海燕，颜林枫，张欣，等．基于直方图分析法定量评估DCE-MRI在脑胶质瘤分级诊断中的价值．磁共振成像, 2018, 9(10): 731-736.
[6]
熊佳佳，于韬．磁共振功能性成像用于胶质瘤术前术中的研究进展.磁共振成像, 2018, 9(5): 391-395.
[7]
Goda JS, Dutta D, Raut N, et al. Can multiparametric MRI and FDG-PET predict outcome in diffuse brainstem glioma? A report from a prospective phase-II study. Pediatr Neurosurg, 2013, 49(5): 274-281.
[8]
Zukotynski KA, Fahey FH, Kocak M, et al. Evaluation of 18F-FDG PET and MRI associations in pediatric diffuse intrinsic brain stem glioma: a report from the pediatric brain tumor consortium. J Nucl Med, 2011, 52(2): 188-195.
[9]
Zukotynski KA, Vajapeyam S, Fahey FH, et al. Correlation of 18F-FDG PET and MRI apparent diffusion coefficient histogram metrics with survival in diffuse intrinsic pontine glioma: a report from the pediatric brain tumor consortium. J Nucl Med, 2017, 58(8): 1264-1269.
[10]
Williams G, Fahey FH, Treves ST, et al. Exploratory evaluation of two-dimensional and three-dimensional methods of FDG PET quantification in pediatric anaplastic astrocytoma: a report from the pediatric brain tumor consortium (PBTC). Eur J Nucl Med Mol Imaging, 2008, 35(9): 1651-1658.
[11]
Galldiks N, Ullrich R, Schroeter M, et al. Volumetry of [(11)C]-methionine PET uptake and MRI contrast enhancement in patients with recurrent glioblastoma multiforme. Eur J Nucl Med Mol Imaging, 2010, 37(1): 84-92.
[12]
Grosu AL, Weber WA, Riedel E, et al. L-（methyl-11C) methionine positron emission tomography for target delineation in resected high-grade gliomas before radiotherapy. Int J Radiat Oncol Biol Phys, 2005, 63(1): 64-74.
[13]
Yamasaki F, Kurisu K, Kajiwara Y, et al. Magnetic resonance spectroscopic detection of lactate is predictive of a poor prognosis in patients with diffuse intrinsic pontine glioma. Neuro Oncol, 2011, 13(7): 791-801.
[14]
Zukotynski KA, Fahey FH, Vajapeyam S, et al. Exploratory evaluation of MR permeability with 18F-FDG PET mapping in pediatric brain tumors: a report from the pediatric brain tumor consortium. J Nucl Med, 2013, 54(8): 1237-1243.
[15]
Dellaretti M, Reyns N, Touzet G, et al. Diffuse brainstem glioma: prognostic factors. J Neurosurg, 2012, 117(5): 810-814.
[16]
Hipp SJ, Steffen-Smith E, Hammoud D, et al. Predicting outcome of children with diffuse intrinsic pontine gliomas using multiparametric imaging. Neuro Oncol, 2011, 13(8): 904-909.
[17]
Kracht LW, Miletic H, Busch S, et al. Delineation of brain tumor extent with [11C] L-methionine positron emission tomography: local comparison with stereotactic histopathology. Clin Cancer Res, 2004, 10(21): 7163-7170.
[18]
Kobayashi K, Hirata K, Yamaguchi S, et al. Prognostic value of volume-based measurements on (11) C-methionine PET in glioma patients. Eur J Nucl Med Mol Imaging, 2015, 42(7): 1071-1080.
[19]
Yoo MY, Paeng JC, Cheon GJ, et al. Prognostic value of metabolic tumor volume on (11) C-Methionine PET in predicting progression-free survival in high-grade glioma. Nucl Med Mol Imaging, 2015, 49(4): 291-297.
[20]
Kinoshita M, Arita H, Goto T, et al. A novel PET index, 18F-FDG-11C-methionine uptake decoupling score, reflects glioma cell infiltration. J Nucl Med, 2012, 53(11): 1701-1708.
[21]
Lucas JT Jr, Serrano N, Kim H, et al. 11C-Methionine positron emission tomography delineates non-contrast enhancing tumor regions at high risk for recurrence in pediatric high-grade glioma. J Neurooncol, 2017, 132(1): 163-170.
[22]
Takenaka S, Asano Y, Shinoda J, et al. Comparison of (11)C-methionine, (11)C-choline, and (18)F-fluorodeoxyglucose-PET for distinguishing glioma recurrence from radiation necrosis. Neurol Med Chir (Tokyo), 2014, 54(4): 280-289.

PREV The value of FLAIR vascular hyperintensity in evaluating the outcome of stroke after non-reperfusion therapy
NEXT MRI typing study of microcystic meningiomas
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn