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• Clinical Article •
Prognostic value of combined PET and MRI volume analysis in brainstem glioma
WANG Kai  ZHAO Xiaobin  LI Deling  WU Yuliang  QIAO Zhen  ZHANG Liwei  AI Lin 

Cite this article as: Wang K, Zhao XB, Li DL, et al. Prognostic value of combined PET and MRI volume analysis in brainstem glioma. Chin J Magn Reson Imaging, 2020, 11(1): 11-15. DOI:10.12015/issn.1674-8034.2020.01.003.


[Abstract] Objective: To investigate the prognostic value of the 3-dimensional volumetric data assessed using MRI and 11C-labeled methionine (MET) PET combined with the presence of oligodendroglial component in patients with brainstem gliomas (BSG).Materials and Methods: Baseline pre-surgical brain 11C-MET PET and MRI scans were prospectively performed in 41 patients with BSG between March 2015 and July 2016, and all patients underwent neurosurgery in our institute. Three-dimensional volumetric data of contrast enhancement and metabolic tumor volume (MTV) was calculated by using contrast-enhanced T1 weighted images and PET images on post-processing station automatically, and then the enhancement volume (EV)-to-MTV ratio was calculated. The Kaplan-Meier method and Cox regression model were used to identify prognostic factors for overall survival.Results: BSG patients with EV-to-MTV ratios ≤50% demonstrated a significantly better survival at 3 months (P=0.015) and 12 months (P=0.018) following tumor resection compared to those with EV-to-MTV ratios> 50%. Furthermore, the EV (P=0.036), EV-to-MTV ratio (P=0.018), tumor grade (P=0.003), and adjuvant therapy (P= 0.003) were significant prognostic factors for overall survival in BSG patients.Conclusions: Patients with a lower EV-to-MTV ratio were more likely to achieve better prognosis than those with a higher ratio. In addition, this ratio might add more indicative prognostic value compared to single imaging index or pathological information.
[Keywords] glioma；brain stem；magnetic resonance imaging；positron emission tomography computed tomography；prognosis

WANG Kai Department of Nuclear Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing 100160, China

ZHAO Xiaobin Department of Nuclear Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing 100160, China

LI Deling Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100160, China

WU Yuliang Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100160, China

QIAO Zhen Department of Nuclear Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing 100160, China

ZHANG Liwei Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100160, China

AI Lin* Department of Nuclear Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing 100160, China

*Correspondence to: Ai L, E-mail: ailin@bjtth.org

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was supported by Beijing Special Program of the Talents NO. 2017000021469G278
Received  2019-02-23
Accepted  2019-11-21
DOI: 10.12015/issn.1674-8034.2020.01.003
Cite this article as: Wang K, Zhao XB, Li DL, et al. Prognostic value of combined PET and MRI volume analysis in brainstem glioma. Chin J Magn Reson Imaging, 2020, 11(1): 11-15. DOI:10.12015/issn.1674-8034.2020.01.003.

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