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• Clinical Article •
Predictive value of temporal muscle thickness measurements on cranial magnetic resonance images in the prognosis of patients with primary glioblastoma
LIU Fang  XING Dong  ZHA Yunfei  LI Liang  GONG Wei  HU Lei 

Cite this article as: Liu F, Xing D, Zha YF, et al. Predictive value of temporal muscle thickness measurements on cranial magnetic resonance images in the prognosis of patients with primary glioblastoma. Chin J Magn Reson Imaging, 2020, 11(1): 20-24. DOI:10.12015/issn.1674-8034.2020.01.005.


[Abstract] Objective: To investigate the predictive value of prognosis in patients with glioblastoma (GBM) by temporal muscle thickness (TMT) on three-dimensional MR images of the brain.Materials and Methods: One hundred and six primary GBM patients from the TCGA-GBM database were analyzed retrospectively. TMT was measured on three-dimensional MR images of the brain, and 30 patients were randomly selected for repetitive measurement by a second radiologist to calculate the inter-class correlation (ICC). The Kaplan-Meier curve was used to calculate the overall survival time of the patients. The median survival time was compared by Log-rank test. The Cox regression model was used for multivariate analysis.Results: TMT was reproducibly assessable on three-dimensional MR images, and the ICC calculated by two radiologists of the left and right side TMT were 0.878 and 0.895 (P<0.001). Decreased TMT is a risk factor related to the prognosis in the patients with GBM, with a hazard ratio (HR) of 0.787 (95%CI 0.678-0.913; P=0.002; Cox regression model). That was the risk of death would increase by 21.3% with every millimeter decrease in TMT. Grouped by median TMT, patients with a TMT> median showed a significant increase in survival time (17.4 months) compared to patients with a TMT<median (9.4 months)(P<0.001; Log-rank test). In the multivariate survival analysis using a Cox regression model, TMT (HR 0.850; 95%CI 0.734-0.984; P=0.03), tumor diagnosis age (HR 1.037; 95%CI 1.018—1.056; P<0.001) and concurrent chemoradiotherapy (HR 0.567; 95%CI 0.371—0.868; P=0.009) were dramatically associated with survival time.Conclusions: TMT can be used as an independent predictor of survival prognosis in patients with primary glioblastoma and contributes to assess the survival time of them.
[Keywords] glioblastoma；temporal muscle thickness；magnetic resonance imaging；overall survival time；sarcopenia

LIU Fang Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

XING Dong Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

ZHA Yunfei* Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

LI Liang Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

GONG Wei Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

HU Lei Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

*Correspondence to: Zha YF, E-mail: zhayunfei999@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This thesis is sponsored by the National Natural Science Foundation of China No. 81801670, 81871332
Received  2019-09-26
Accepted  2019-11-21
DOI: 10.12015/issn.1674-8034.2020.01.005
Cite this article as: Liu F, Xing D, Zha YF, et al. Predictive value of temporal muscle thickness measurements on cranial magnetic resonance images in the prognosis of patients with primary glioblastoma. Chin J Magn Reson Imaging, 2020, 11(1): 20-24. DOI:10.12015/issn.1674-8034.2020.01.005.

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