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• Clinical Article •
Study on biological characteristics of rectal cancer based on magnetic resonance diffusion kurtosis imaging
WANG Lili  LI Shenghu  HUANG Gang  XU Huaxin  CUI Yaqiong  MA Xiaomei  CUI Lanlan 

Cite this article as: Wang LL, Li SH, Huang G, et al. Study on biological characteristics of rectal cancer based on magnetic resonance diffusion kurtosis imaging. Chin J Magn Reson Imaging, 2020, 11(1): 35-39. DOI:10.12015/issn.1674-8034.2020.01.008.


[Abstract] Objective: Based on magnetic resonance diffusion kurtosis imaging, the relationship between staging, differentiation, histological type, p53 and HER-2 was investigated.Materials and Methods: A retrospective analysis of 63 cases of rectal cancer patients from 2017 to 2019, MRI examination within one week before surgery, the examination sequence contain DKI imaging and the data obtained were imported into special software for analysis. The DKI parameter and postoperative pathological biological characteristics were obtained for statistical analysis. One-way ANOVA was used to compare the relationship between DKI parameters in histologic type, tumor stage, degree of differentiation, p53 and HER-2 group. The Kruskal-Wallis H test analyzes whether the biological characteristics of rectal cancer have an effect on DKI parameter. Spearman correlation coefficient analysis biological relationship and DKI parameter. The ROC curve was used to analyze the diagnostic efficacy of DKI parameter for p53 and HER-2 negative or positive, P<0.05 was considered statistically significant.Results: (1) The histological type, tumor stage and degree of differentiation have different effects on DKI parameter. (2) MK and rectal cancer stage and differentiation were statistically significant, positively correlated with stage, and negatively correlated with degree of differentiation (r=0.285, -0.296). MD was negatively correlated with histological type (r=-0.375). There was a positive correlation between FA and p53, degree of differentiation (r=0.254, 0.256), and a negative correlation with rectal stage (r=-0.315, -0.399). (3) The area under the FA prediction p53 performance curve was 0.651, indicating a moderate diagnostic efficiency with a 95% confidence interval (0.502, 0.800).Conclusions: Significant correlations were found between the magnetic resonance diffusion kurtosis imaging and the biological characteristics of rectal cancer, which maybe guide for the prognosis and treatment options of rectal cancer.
[Keywords] rectal neoplasms；magnetic resonance imaging；immunohistochemistry

WANG Lili Department of radiology, Gansu Provincial Hospital, Lanzhou 730000, China

LI Shenghu* Department of radiology, Wuxi Hospital of traditional Chinese medicine, Jiangsu Province, Wuxi 214000, China

HUANG Gang Department of radiology, Gansu Provincial Hospital, Lanzhou 730000, China

XU Huaxin Department of radiology, Gansu Provincial Hospital, Lanzhou 730000, China

CUI Yaqiong Department of radiology, Gansu Provincial Hospital, Lanzhou 730000, China

MA Xiaomei Department of radiology, Gansu Provincial Hospital, Lanzhou 730000, China

CUI Lanlan Department of radiology, Gansu Provincial Hospital, Lanzhou 730000, China

*Correspondence to: Li SH, E-mail: shenghuli@foxmail.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This article is funded by scientific research project of fund for Scientific and technological Development in Lanzhou City, Gansu Province No.16GSSY1-7 This article is funded by scientific research project of scientific research fund of gansu provincial hospital No. 2015-ZD-21
Received  2019-08-01
Accepted  2019-11-21
DOI: 10.12015/issn.1674-8034.2020.01.008
Cite this article as: Wang LL, Li SH, Huang G, et al. Study on biological characteristics of rectal cancer based on magnetic resonance diffusion kurtosis imaging. Chin J Magn Reson Imaging, 2020, 11(1): 35-39. DOI:10.12015/issn.1674-8034.2020.01.008.

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