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• Clinical Article •
Diagnostic value of IVIM for benign and malignant identification of epithelial ovarian tumors and its correlation with ki67 expression
CUI Yunhui  ZHU Shaocheng  LI Hongxiang  LIU Yuanyuan 

Cite this article as: Cui YH, Zhu SC, Li HX, et al. Diagnostic value of IVIM for benign and malignant identification of epithelial ovarian tumors and its correlation with ki67 expression. Chin J Magn Reson Imaging, 2020, 11(1): 45-49. DOI:10.12015/issn.1674-8034.2020.01.010.


[Abstract] Objective: To investigate the value of intravoxel incoherent motion (IVIM) parameters in the identification of epidermal ovarian tumors, and the correlation between ovarian cancer and ki67 expression.Materials and Methods: The data of MR plain scan, IVIM and routine enhancement examination of 73 patients with epidermal ovarian tumor (27 cases of benign tumor and 46 cases of malignant tumor) confirmed by surgical pathology were retrospectively analyzed. IVIM parameter values (ADC, Dslow, Dfast and f) were analyzed and measured, and the differences in each parameter between benign and malignant groups were compared. The ROC curve was drawn to evaluate the efficacy of various parameters in the differential diagnosis of epidermal ovarian tumors, and the diagnostic boundary value, sensitivity and specificity of each parameter were calculated. The correlation between IVIM parameter value and expression level of ki67 was analyzed.Results: ADC, Dslow and f values of the benign group were all higher than those of the malignant group (all P<0.05). There was no statistical difference in Dfast between the two groups (P=0.059). Among them, ADC value has extremely high sensitivity and Dslow and f value have high specificity. Dslow value had the highest efficacy in differentiating benign and malignant ovarian tumors from epidermal tumors, with the area under the ROC curve being 0.934 (P<0.01), the optimal threshold being 0.853×10-3 mm2/s, and the sensitivity and specificity being 85.2% and 87%, respectively. ADC, Dslow, and f were all negatively correlated with ki67 (P<0.05), while Dfast was not significantly correlated with ki67 (P>0.05).Conclusions: IVIM is helpful in identifying benign and malignant epidermal ovarian tumors, in which the sensitivity of ADC value is extremely high, while the specificity of Dslow and f value is high, which has certain reference significance for clinical diagnosis. Some IVIM parameters are related to the expression of ki67, so it can indirectly provide help for the prognosis assessment of ovarian cancer.
[Keywords] ovarian neoplasms；magnetic resonance imaging；diagnosis, differential

CUI Yunhui Graduate Department of Xinxiang Medical University, Henan Province, Xinxiang 453003, China; Department of Radiology, People's Hospital of Henan Province, Zhengzhou 450003, China

ZHU Shaocheng* Department of Radiology, People's Hospital of Henan Province, Zhengzhou 450003, China

LI Hongxiang Department of Radiology, People's Hospital of Henan Province, Zhengzhou 450003, China

LIU Yuanyuan Department of Radiology, People's Hospital of Henan Province, Zhengzhou 450003, China

*Correspondence to: Zhu SC, E-mail: ZSC2686@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This article is supported by the Henan Provincial Medical Science and Technology Research Project No. SBGJ2018068 Henan Science and Technology Research Project No. 182102311176
Received  2019-07-19
Accepted  2019-11-21
DOI: 10.12015/issn.1674-8034.2020.01.010
Cite this article as: Cui YH, Zhu SC, Li HX, et al. Diagnostic value of IVIM for benign and malignant identification of epithelial ovarian tumors and its correlation with ki67 expression. Chin J Magn Reson Imaging, 2020, 11(1): 45-49. DOI:10.12015/issn.1674-8034.2020.01.010.

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