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• MRI in Acupuncture Study •
The preliminary study of clinical efficacy and brain mechanism of auricular electro-acupuncture on treatment-tesistant depression monitored by resting state fMRI
LI Xiaojiao  XU Ke  FANG Jiliang  HONG Yang  CHEN Limei  GAO Deqiang  ZHANG Lei  XU Fengquan  WANG Hongxing 

Cite this article as: Li XJ, Xu K, Fang JL, et al. The preliminary study of clinical efficacy and brain mechanism of auricular electro-acupuncture on treatment-tesistant depression monitored by resting state fMRI. Chin J Magn Reson Imaging, 2020, 11(2): 84-88. DOI:10.12015/issn.1674-8034.2020.02.002.


[Abstract] Objective: To observe the clinical efficacy of auricular electro-acupuncture on treatment-resistant depression (TRD), and then to explore its brain mechanism monitored by resting state functional magnetic resonance imaging (rs-fMRI).Materials and Methods: 20 patients with TRD were enrolled with the auricular electro-acupuncture for 8 weeks. Before the treatment (week 0) and after treatment (week 8), 17 Hamilton Depression Scale (HAMD-17) was used to evaluate its antidepressant effect; Using rs-fMRI technique. The rs-fMRI scans were performed on a 3.0 T MRI scanner (Magnetom Skyra, Siemens, Germany) before and after 8-week. We selected the bilateral rACC as the seed regions to compare the changes of functional connectivity (FC) before and after treatment. Finally to analyze the correlation between clinical efficacy and changes in FC after 8 weeks in TRD.Results: 17 subjects with TRD completed clinical studies. Comparing the HAMD-17 scores between 0 week and 8 weeks after treatment, the differences show statistically significant (P<0.001). 9 subjects with TRD completed brain mechanism studies. FC increased between the right rACC and the left Precuneus/ Postcentral_L(aal), the left rACC and left Lingual Gyrus/left Precuneus/Postcentral_L(aal); FC decreased between the left rACC and the right Precuneus. The FC increases between the left rACC and left lingual gyrus was significantly positively associated with the HAMD-17 score reduction (r=0.840, P=0.005).Conclusions: Auricular electro-acupuncture is effective in the treatment of TRD. Its antidepressant effects is possible related with the FC between rACC and precuneus, rACC and lingual gyrus.
[Keywords] auricular concha；electroacupuncture；depression；functional magnetic resonance imaging

LI Xiaojiao Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China

XU Ke Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China

FANG Jiliang* Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China

HONG Yang* Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China

CHEN Limei Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China

GAO Deqiang Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China

ZHANG Lei Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China

XU Fengquan Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China

WANG Hongxing Beijing Xuanwu Hospital, Capital Medical University, Beijing 100053, China

*Correspondence to: Fang JL, E-mail: fangmgh@163.com; Hong Y, E-mail: hongyang671129@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foundation of China No. 81774433 The National Key Research and Development Program of China No. 2018YFC1705802
Received  2019-12-04
Accepted  2020-01-08
DOI: 10.12015/issn.1674-8034.2020.02.002
Cite this article as: Li XJ, Xu K, Fang JL, et al. The preliminary study of clinical efficacy and brain mechanism of auricular electro-acupuncture on treatment-tesistant depression monitored by resting state fMRI. Chin J Magn Reson Imaging, 2020, 11(2): 84-88. DOI:10.12015/issn.1674-8034.2020.02.002.

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