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• MRI in Acupuncture Study •
Study on fMRI of brain resting state in patients with mild cognitive impairment treated by acupuncture
WANG Feng  WEI Shuqin  LI Xiaoling  CAO Danna  ZHANG Kunyu  LIU Xiaohui  CAI Li’na  JIANG Xiaoxu  NIE Shouping 

Cite this article as: Wang F, Wei SQ, Li XL, et al. Study on fMRI of brain resting state in patients with mild cognitive impairment treated by acupuncture. Chin J Magn Reson Imaging, 2020, 11(2): 94-98. DOI:10.12015/issn.1674-8034.2020.02.004.


[Abstract] Objective: To analyze the changes of amplitude of low-frequency fluctuation (ALFF) in brain region of patients with mild cognitive impairment (MCI) before and after acupuncture treatment, and to explore the central mechanism of acupuncture in patients with MCI.Materials and Methods: The patients with MCI who met the inclusion criteria were treated with "Yuanluo Tongjing" acupuncture therapy for 28 days. The clinical efficacy was evaluated by mini-mental state examination (MMSE) and montreal cognitive assessment (MoCA), statistical analysis was performed using SPSS 25.0 statistical software package. Resting state functional magnetic resonance imaging (rs-fMRI) was used with 3.0 T magnetic resonance scanner before and after treatment. The image data were preprocessed by DPARSFA software to obtain ALFF imaging indexes, then SPM12 and xjView software were used to analyze and present the results.Results: Compared with the pre-treatment, the scores of MMSE and MoCA after acupuncture treatment were significantly different (P<0.001) and the scores increased. Compared with before treatment, the brain areas with increased ALFF value in patients with MCI after acupuncture treatment were as follows: right perihippocampal gyrus, left thalamus, right insular lobe, left anterior cingulate gyrus; the decreased ALFF value were: left posterior cerebellar lobe, left infratemporal gyrus, right infratemporal gyrus, left middle temporal gyrus, left suboccipital gyrus and left superior parietal lobule.Conclusions: The ALFFvalue of multiple brain regions changed before and after acupuncture treatment in MCI patients. Acupuncture enhanced the neural activity of brain areas related to cognitive function, and also decreased the ALFF value of compensated brain areas with enhanced pretherapy functional activity. it is speculated that acupuncture treatment of MCI can improve the symptoms of patients by regulating the neural activity of multiple brain regions.
[Keywords] acupuncture；Yuanluo Tongjing acupuncture therapy；mild cognitive impairment；functional magnetic resonance imaging；amplitude of low-frequency fluctuation

WANG Feng Heilongjiang University of Chinese Medicine, Harbin 150040, China; First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040, China

WEI Shuqin Central Hospital of Heilongjiang Agricultural Reclamation Hongxinglong Administration Bureau, Shuangyashan 155811, China

LI Xiaoling* First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040, China

CAO Danna Heilongjiang University of Chinese Medicine, Harbin 150040, China; First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040, China

ZHANG Kunyu Heilongjiang University of Chinese Medicine, Harbin 150040, China

LIU Xiaohui Heilongjiang University of Chinese Medicine, Harbin 150040, China

CAI Li’na Heilongjiang University of Chinese Medicine, Harbin 150040, China

JIANG Xiaoxu Heilongjiang University of Chinese Medicine, Harbin 150040, China

NIE Shouping Heilongjiang University of Chinese Medicine, Harbin 150040, China

*Correspondence to: Li XL, E-mail: lixiaoling1525@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Natural Science Foundation of China No. 81973930, 81373714 Heilongjiang Province Natural Science Foundation No. H2016081 Ministry of Education "Chunhui plan" Project No. Z2009-1-15030 Harbin Science and Technology Innovation Talent Excellent Discipline Leader Fund Project No. 2016RAXYJ096 Harbin Science and Technology Innovation Talent Research Special Fund Project No. 2017RAQXJ180 Heilongjiang University of Traditional Chinese Medicine Research Fund Project No. 201704 Heilongjiang University of Chinese Medicine Graduate Student Innovation Research Project No. 2019yjscx024
Received  2019-10-18
Accepted  2019-12-13
DOI: 10.12015/issn.1674-8034.2020.02.004
Cite this article as: Wang F, Wei SQ, Li XL, et al. Study on fMRI of brain resting state in patients with mild cognitive impairment treated by acupuncture. Chin J Magn Reson Imaging, 2020, 11(2): 94-98. DOI:10.12015/issn.1674-8034.2020.02.004.

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