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• Clinical Article •
The comparation of magnetic resonance spectroscopy using different sequence parameters in the prognosis of acute cerebral infarction
SHANG Wenwen  JIANG Liang  XUE Hailin  XUE Lian 

Cite this article as: Shang WW, Jiang L, Xue HL, et al. The comparation of magnetic resonance spectroscopy using different sequence parameters in the prognosis of acute cerebral infarction. Chin J Magn Reson Imaging, 2020, 11(2): 104-108. DOI:10.12015/issn.1674-8034.2020.02.006.


[Abstract] Objective: To investigate the clinical application value of magnetic resonance spectroscopy (MRS) in the treatment of acute cerebral infarction by using PRESS sequence-long echo time and STEAM sequence-short echo time scan.Materials and Methods: 27 patients with acute cerebral infarction were scanned by regular magnetic resonance and magnetic resonance spectroscopy using both PRESS sequence-long echo time and STEAM sequence-short echo time. Then the changes of metabolites on the infarct side and its correlation with mRS after three months were analyzed statistically and the results of two different MRS scan ways were compared.Results: (1) The contentions of NAA, Cho, Cr and the ratios of NAA/Cr, Cho/Cr in the infraction region were detected changes by two different MRS scanning techniques, but there was no significant difference between the two scan results. Lac was detected in some patients using PRESS sequence-long echo time scan, while Lac and short T2 substances such as mI and Glx were detected in the STEAM sequence-short echo time scan. (2) There were significantly negatively correlation between the ratios of rNAA, NAA/Cr and mRS scale after 3 months by using PRESS sequence-long echo time and STEAM sequence-short echo time scan. (3) The receiver operating characteristic curve showed that the sensitivity of rNAA, rCr and NAA/Cr in the infraction region to predict the prognosis of patients with acute cerebral infarction were 88.9%, 66.7%, 77.8% and specificity were 80%, 80%, 60% by using STEAM sequence-short echo time scan; while the sensitivity of 57.1%, 28.6%, 57.1%, and specificity of 75%, 87.5%, 87.5% by using PRESS sequence-long echo time scan.Conclusions: There have good consistency between PRESS sequence-long echo and STEAM sequence-short echo scan, which can detect changes of metabolites to reflect pathological changes in infarct areas. However, STEAM sequence-short echo scan can detect more species of metabolite abnormalities, and is superior to PRESS long echo in predicting prognosis of acute cerebral infarction.
[Keywords] stroke；point resolved spectroscopy；stimulated echo acquisition mode；short echo time；long echo time；magnetic resonance spectroscopy

SHANG Wenwen School of Radiology, Jiangsu Vocational College of Medicine, Yancheng 224000, China

JIANG Liang Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China

XUE Hailin Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China

XUE Lian* Department of Radiology, Clifford Hospital, Guangzhou University of Chinese Medicine, Guangzhou 511495, China

*Correspondence to: Xue L, E-mail: xuelian-1982@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of High Level Backbone Major Construction Project of Higher Vocational Education in Jiangsu Province No. 2017JSGG163 Medical Science and Technology Development Project of Yancheng in 2016 No. YK2016052
Received  2019-07-25
Accepted  2019-10-18
DOI: 10.12015/issn.1674-8034.2020.02.006
Cite this article as: Shang WW, Jiang L, Xue HL, et al. The comparation of magnetic resonance spectroscopy using different sequence parameters in the prognosis of acute cerebral infarction. Chin J Magn Reson Imaging, 2020, 11(2): 104-108. DOI:10.12015/issn.1674-8034.2020.02.006.

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