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• Clinical Article •
Analysis of cerebral small vessel disease and clinical factors in young patients with symptomatic cerebral infarction
JIANG Yuhan  MIAO Yanwei  WANG Weiwei  CHE Yiwei  CHANG Peipei  SONG Qingwei  WEI Qiang  LIU Ailian 

Cite this article as: Jiang YH, Miao YW, Wang WW, et al. Analysis of cerebral small vessel disease and clinical factors in young patients with symptomatic cerebral infarction. Chin J Magn Reson Imaging, 2020, 11(2): 113-117. DOI:10.12015/issn.1674-8034.2020.02.008.


[Abstract] Objective: Cerebral small vessel disease (CSVD) is considered to be a common manifestation of senile cerebrovascular disease, and has a clear correlation with clinical symptoms and characteristics. At the present, limited studies are available for investigating the CSVD in young patients with cerebral infarction have CSVD and the impacting clinical factor, which is the aim of this explorative study.Materials and Methods: A total of 111 cases of primary acute cerebral infarction were enrolled in this study, including 54 cases of young cerebral infarction (43 men and 11 women; 39.5 yrs) with the age less than 45 years old and 57 cases of senile cerebral infarction (37 men and 20 women; 69 yrs). Ethical approval was obtained in the local institute and consent forms were obtained. Clinical data of all patients at admission were collected, including blood pressure, fasting blood glucose, total cholesterol, triglyceride, high density lipoprotein, low density lipoprotein, homocysteine, and smoking and drinking. All subjects underwent routine MR sequences (including T1WI, T2WI and T2 FLAIR) and DWI on 1.5 T MRI scanner. Two experienced radiologists evaluated the CSVD independently as the following: enlarged perivascular spaces (EPVS) were counted and scored in basal ganglia (BG) and centrum semiovale (CS); lacunar infarction (LI) were counted, white matter hyperintensity lesions (WMH) were graded and recorded. To reduce the bias in assessment of the severity of the patient's CSVD, the patient's EPVS, WMH, LI, and CMBs scores were collectively accounted to derive the total burden scores of CSVD (TBS) (0-4 scores). The Kruskal-Wallis H test were used to compare the ranked data between groups. Correlation between CSVD and clinical factors were assessed by Multivariate Logistic regression analysis.Results: Difference among the scores of the three groups was observed (P<0.01). Based on a pair-to-pair comparison, there was significant difference in TBS among the three groups (P<0.05 after adjustment). The score of the infarction group was significantly higher than that of the control group, but significantly lower than the aged group. Hypertension was observed as the influencing factor of EPVS and the influencing factors of TBS (P<0.05). Smoking was the influencing factor of CMBs (P<0.05). LI was closely related to age (P<0.05).Conclusions: Young patients with acute symptomatic cerebral infarction often combined with CSVD, and hypertension, smoking and age are the influencing factors.
[Keywords] stroke；cerebral small vessel disease；clinical factors；magnetic resonance imaging

JIANG Yuhan Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

MIAO Yanwei* Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

WANG Weiwei Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

CHE Yiwei Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

CHANG Peipei Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

SONG Qingwei Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

WEI Qiang Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

LIU Ailian Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

*Correspondence to: Miao YW, E-mail: ywmiao716@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foundation of China No. 81671646, 81801657
Received  2019-09-20
Accepted  2019-11-29
DOI: 10.12015/issn.1674-8034.2020.02.008
Cite this article as: Jiang YH, Miao YW, Wang WW, et al. Analysis of cerebral small vessel disease and clinical factors in young patients with symptomatic cerebral infarction. Chin J Magn Reson Imaging, 2020, 11(2): 113-117. DOI:10.12015/issn.1674-8034.2020.02.008.

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