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• Clinical Article •
Correlation between IVIM-DWI quantitative parameter histogram and Ki-67 proliferation index of breast cancer
LIU Yulin  ZHANG Rong  YUE Li’na  LU Dongmei  LIU Ying  YANG Xiaoping 

Cite this article as: Liu YL, Zhang R, Yue LN, et al. Correlation between IVIM-DWI quantitative parameter histogram and Ki-67 proliferation index of breast cancer. Chin J Magn Reson Imaging, 2020, 11(2): 118-123. DOI:10.12015/issn.1674-8034.2020.02.009.


[Abstract] Objective: To explore the correlation between histogram quantitative parameters of diffusion-weighted imaging (DWI) single index and intravoxel incoherent motion (IVIM) dual index model and Ki-67 proliferation index of breast cancer.Materials and Methods: A retrospective analysis of 56 patients with pathologically confirmed breast cancer, a total of 57 lesions. All the subjects were performed preoperatively with MRI examination (plain scan, multi-b value DWI and dynamic contrast-enhanced), IVIM histogram parameters (ADC, D, D*, and f) were obtained by post-processing software, including minimum, maximum, mean, 10th, 25th, 50th (median), 75th, 90th, skewness and kurtosis. IVIM histogram parameters (ADC, D, D*, and f) of patients with different Ki-67 expression were compared to explore the relationships between MRI and immunohistochemical findings of patients with breast cancer; Correlation between histogram parameters and breast cancer Ki-67 proliferation index by Spearman correlation coefficient.Results: The ADC value (skewness and kurtosis), D value (skewness and kurtosis), D* value (mean, maximum, skewness and kurtosis) in the Ki-67 high-expression group were significantly higher than those in the Ki-67 low-expression group, D* value (minimum) in the Ki-67 high-expression group was lower than that of Ki-67 low-expression group (P<0.05), while no significant differences were showed in all histogram parameters of f-value between the two groups (P>0.05). ADC value (skewness and kurtosis), D value(skewness and kurtosis), D* value (mean, maximum, skewness and kurtosis) were positively correlated with Ki-67 proliferation index (r=0.296—0.509, P<0.05), D* value (minimum) was negatively correlated with Ki-67 proliferation index (r=-0.262, P<0.05).Conclusions: IVIM-DWI histogram quantitative parameters were correlated with Ki-67 proliferation index of breast cancer, and the maximum value of D* has the highest correlation. This may indicate the potential to provide a surrogate measure of Ki-67 expression through non-invasive imaging methods.
[Keywords] breast neoplasms；magnetic resonance imaging；Ki-67；diffusion-weighted imaging；intravoxel incoherent motion

LIU Yulin The Second Clinical Medical College of Lanzhou University, Lanzhou 730030, China; Department of Imaging Diagnosis, the 940th Hospital of Joint Logistics Support force of Chinese People’s Liberation Army, Lanzhou 730050, China

ZHANG Rong The Second Clinical Medical College of Lanzhou University, Lanzhou 730030, China; Department of Imaging Diagnosis, the 940th Hospital of Joint Logistics Support force of Chinese People’s Liberation Army, Lanzhou 730050, China

YUE Li’na Department of Imaging Diagnosis, the 940th Hospital of Joint Logistics Support force of Chinese People’s Liberation Army, Lanzhou 730050, China

LU Dongmei Department of Imaging Diagnosis, the 940th Hospital of Joint Logistics Support force of Chinese People’s Liberation Army, Lanzhou 730050, China

LIU Ying Department of Breast Surgery, the 940th Hospital of Joint Logistics Support force of Chinese People's Liberation Army, Lanzhou 730050, China

YANG Xiaoping* Department of Imaging Diagnosis, the 940th Hospital of Joint Logistics Support force of Chinese People’s Liberation Army, Lanzhou 730050, China

*Correspondence to: Yang XP, E-mail: lwyxp_zxl@sohu.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Natural Science Foundation of Gansu Province No. 1606RJZA160
Received  2019-11-15
Accepted  2019-12-31
DOI: 10.12015/issn.1674-8034.2020.02.009
Cite this article as: Liu YL, Zhang R, Yue LN, et al. Correlation between IVIM-DWI quantitative parameter histogram and Ki-67 proliferation index of breast cancer. Chin J Magn Reson Imaging, 2020, 11(2): 118-123. DOI:10.12015/issn.1674-8034.2020.02.009.

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