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• Original Article •
Study on behavior of different surface charge nanoparticles through the extravascular fluid transport pathway
LI Qing  CAO Yupeng  ZHOU Xiaohan  LIU Wentao  LI Hongyi 

Cite this article as: Li Q, Cao YP, Zhou XH, et al. Study on behavior of different surface charge nanoparticles through the extravascular fluid transport pathway. Chin J Magn Reson Imaging, 2020, 11 (2): 134-140. DOI:10.12015/issn.1674-8034.2020.02.012.


[Abstract] Objective: To observe the transport behavior of different surface charge ferric oxide nanoparticles in the extravascular fluid transport pathway using magnetic resonance imaging.Materials and Methods: Twelve SD rats aged 6-7 weeks were divided into neutral, positive group and negative group, with 4 in each group. The lower extremity Taixi acupoint was the injection site, the magnetic resonance images of the three groups of rats were detected by Bruker's high magnetic field MRI small animal in vivo imaging system before and after injection, and the number of voxel points (volume), displacement and velocity of the signal decreased after injection were calculated and analyzed.Results: After injection, the magnetic resonance images of the electric neutral group, the positive charge group and the negative charge group showed significant decrease in the signal area; the volume of the signal decreased significantly with time (P<0.01). The rate of increase in the signal reduction area of the electric neutral group, the positive charge group and the negative charge group decreased significantly with time (P<0.01), and the cumulative displacement increased. The rate of increase in the signal reduction region between the three groups was significantly different (P<0.05), the average speed of the negative charge group was significantly lower than that of the electric neutral group (P<0.01) and positive charge group (P<0.05). The cumulative displacement of the signal areas of the electric neutral group, the positive charge group and the negative charge group showed a significant upward trend with time (P<0.01), the interaction between the drug groups and the observation time was statistically significant (P<0.01). Over time, the cumulative displacement between drug groups is different, and the cumulative displacement of electrically neutral and positively charged nanoparticles is longer than the negatively charged.Conclusions: The transport speed of positively charged and electrically neutral nanoparticles in the extravascular fluid transport system is higher than the negative charge. The effect of surface charge should be considered when studying the extravascular fluid transport system as the route of administration.
[Keywords] vascular adventitia；surface charge；nanoparticles；magnetic resonance imaging；animal experimentation

LI Qing Beijing Hospital, National Center for Gerontology, Beijing 100730, China

CAO Yupeng National Center for Nanoscience and Technology, Beijing 100190, China

ZHOU Xiaohan National Center for Nanoscience and Technology, Beijing 100190, China

LIU Wentao National Center for Nanoscience and Technology, Beijing 100190, China

LI Hongyi* Beijing Hospital, National Center for Gerontology, Beijing 100730, China

*Correspondence to: Li HY, E-mail: leehongyi@bjhmoh.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Program on Key Basic Research Project (973 Program) No. 2015CB554507 Beijing Hospital Clinical Research (121 Project) No. 121-2016002
Received  2019-09-11
Accepted  2020-01-07
DOI: 10.12015/issn.1674-8034.2020.02.012
Cite this article as: Li Q, Cao YP, Zhou XH, et al. Study on behavior of different surface charge nanoparticles through the extravascular fluid transport pathway. Chin J Magn Reson Imaging, 2020, 11 (2): 134-140. DOI:10.12015/issn.1674-8034.2020.02.012.

[1]
Stenmark KR, Yeager ME, Kasmi KC, et al. The adventitia: essential regulator of vascular wall structure and function. Annu Rev Physiol, 2013, 75(1): 23-47.
[2]
Fan D, Creemers EE, Kassiri Z. Matrix as an interstitial transport system. Circ Res, 2014, 114(5): 889-902.
[3]
Iliff JJ, Wang M, Liao Y, et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Sci Transl Med, 2012, 4(147): 147.
[4]
Boardman KC, Swartz MA. Interstitial flow as a guide for lymphangiogenesis. Circ Res, 2003, 92(7): 801-808.
[5]
Li HY, Yang CQ, Lu KY, et al. A long-distance fluid transport pathway within fibrous connective tissues in patients with ankle edema. Clin Hemorheol Microcirc, 2016, 63(4): 411-421.
[6]
Li HY, Chen M, Yang JF, et al. Fluid flow along venous adventitia in rabbits: is it a potential drainage system complementary to vascular circulations?. PLoS One, 2012, 7(7): e41395.
[7]
Feng JT, Wang F, Han XX, et al. A “green pathway” different from simple diffusion in soft matter: Fast molecular transport within micro/nanoscale multiphase porous systems. Nano Research, 2014, 7(3): 434-442.
[8]
Li HY, Tong JB, Cao WG, et al. Longitudinal non-vascular transport pathways originating from acupuncture points in extremities visualised in human body. Chin Sci Bullet, 2014, 35: 5090-5095.
[9]
Li HY, Yang CQ, Yin YJ, et al. An extravascular fluid transport system based on structural framework of fibrous connective tissues in human body. Cell Prolif, 2019, 52(5): e12667.
[10]
Hu N, Cao Y, Ao Z, et al. Flow behavior of liquid metal in the connected fascial space: Intervaginal space injection in the rat wrist and mice with tumor. Nano Res, 2018, 11(4): 2265-2276.
[11]
Fonseca-Santos B, Silva PB, Rigon RB, et al. Formulating SLN and NLC as innovative drug delivery systems for non-invasive routes of drug administration. Curr Med Chem, 2019, 26: 1.
[12]
Gindy ME, Prud'homme RK. Multifunctional nanoparticles for imaging, delivery and targeting in cancer therapy. Expert Opin Drug Deliv, 2009, 6(8): 865-878.
[13]
Veiseh O, Gunn JW, Zhang M. Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging. Adv Drug Deliv Rev, 2010, 62(3): 284-304.
[14]
Xu CJ, Sun SH. Superparamagnetic nanoparticles as targeted probes for diagnostic and therapeutic applications. Dalton Trans, 2009, 29: 5583-5591.
[15]
Wei YC, Quan L, Zhou C, et al. Factors relating to the biodistribution& clearance of nanoparticles & their effects on in vivo application. Nanomedicine, 2018, 13(12): 1495-1512.
[16]
Ernsting MJ, Murakami M, Roy A, et al. Factors controlling the pharmacokinetics, biodistribution and intratumoral penetration of nanoparticles. J Control Release, 2013, 172(3): 782-794.
[17]
Sun C, Lee JSH, Zhang M. Magnetic nanoparticles in MR imaging and drug delivery. Adv Drug Deliv Rev, 2008, 60(11): 1252-1265.
[18]
Mignani S, Saïd El Kazzouli, Bousmina M, et al. Expand classical drug administration ways by emerging routes using dendrimer drug delivery systems: a concise overview. Adv Drug Deliv Rev, 2013, 65(10): 1316-1330.
[19]
Li SD, Huang L. Pharmacokinetics and biodistribution of nanoparticles. Mol Pharm, 2008, 5(4): 496-504.
[20]
He CB, Hu YP, Yin LC, et al. Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles. Biomaterials, 2010, 31(13): 3657-3666.
[21]
Dobrovolskaia MA, Aggarwal P, Hall JB, et al. Preclinical studies to understand nanoparticle interaction with the immune system and its potential effects on nanoparticle biodistribution. Mol Pharm, 2008, 5(4): 487-495.
[22]
Shi X, Zhu Y, Hua W, et al. An in vivo study of the biodistribution of gold nanoparticles after intervaginal space injection in the tarsal tunnel. Nano Research, 2016, 9(7): 2097-2109.
[23]
Tunuguntla RH, Henley RY, Yao YC, et al. Enhanced water permeability and tunable ion selectivity in subnanometer carbon nanotube porins. Science, 2017, 357(6353): 792-796.
[24]
Bedussi B, Almasian M, Vos JD, et al. Paravascular spaces at the brain surface: Low resistance pathways for cerebrospinal fluid flow. J Cereb Blood Flow Metab, 2017, 38(4): 719-726.
[25]
Benias PC, Wells RG, Sackey-Aboagye B, et al. Structure and distribution of an unrecognized interstitium in human tissues. Sci rep, 2018, 8(1): 4947.
[26]
Parker JC, Lenhard RJ, Kuppusamy T. A parametric model for constitutive properties governing multiphase flow in porous media. Water Resour Res, 1987, 23(4): 618-624.
[27]
Sun Q, Shi X, Feng J, et al. Cytotoxicity and cellular responses of gold nanorods to smooth muscle cells dependent on surface chemistry coupled action. Small, 2018, 14(52): e1803715.
[28]
Doherty MM, Pang KS. First-pass effect: significance of the intestine for absorption and metabolism. Drug Chem Toxicol, 1997, 20(4): 16.
[29]
Naik A, Kalia YN, Guy RH. Transdermal drug delivery: overcoming the skin's barrier function. Pharm Sci Technolo Today, 2000, 3(9): 318-326.

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