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• Original Article •
3D printing technology improved animal coils to optimize KM mice magnetic resonance imaging study
ZHANG Jie  LI Jiali  SHEN Yaqi  WANG Qiuxia 

Cite this article as: Zhang J, Li JL, Shen YQ, et al. 3D printing technology improved animal coils to optimize KM mice magnetic resonance imaging study. Chin J Magn Reson Imaging, 2020, 11(2): 141-144. DOI:10.12015/issn.1674-8034.2020.02.013.


[Abstract] Objective: To explore optimizing the imaging of KM mice based 5 cm animal coils improved by 3D surface scanning technology.Materials and Methods: A 3D surface scanner was used to scan the 5 cm animal coil, and a mouse scanning holder was designed for optimizing multi-time point imaging of KM mice on 3.0 T MRI. After intraperitoneal anesthesia, 6 KM mice with tumor were scanned with a 5 cm animal coil on a 3.0 T MRI. Compare the images before and after the holder, the number of pre-scans, the entire scanning process, and the start and end times were recorded. The image quality assessment adopted objective and subjective indicators. The objective indicators use SNR (signal to noise ratio) and CNR (contrast to noise ratio). The subjective indicators are graded to three levels by two radiologists by the artifacts of autonomic movement and breathe appearing in the images. The measurement data were analyzed by paired t-test; the ordinal data were analyzed by Wilcoxon's rank sum test, and the test level α is 0.05; the consistency analysis between the two radiologists was evaluated by Cohen's Kappa test.Results: Two magnetic resonance coil holders (referred to as 3D holder) were successfully made using 3D printing technology. Consistency analysis of the autonomic movement and breathe artifacts between the two radiologists showed that the κ values were all above 0.7, indicating good agreement. Without the 3D printing holder, the total pre-scan needs 21 times with a success rate of 28.57% (6/21), and the average scanning time for per KM mouse is 17.6 minutes; after using the 3D holder, it just needed 6 pre-scans in total (Each mouse was pre-scanned successfully once) with a success rate of 100% (6/6). The average scan time for per KM mouse was 10.8 minutes, so the time was shortened by 38.64%. The SNRs before and after using the holder were respectively 2.16±0.18, 2.41±0.14, and CNR were 1.48±0.11 and 1.86±0.14. Paired Wilcoxon's rank sum test was performed, and P<0.05. Compared with the non-3D-printed holder group, using 3D printing holder reduces the autonomic movement and breathe artifacts. The two radiologists respectively graded the autonomous movement and breathe artifacts before and after the 3D printing and performed a paired Wilcoxon's rank sum test with P<0.05.Conclusions: The magnetic resonance animal coil holder using 3D printing technology help to reduce the preparation time of animal MRI scanning, improve the comfort, facilitate the fixation, increase the success rate of scanning and image signal intensity, shorten the scanning time, reduces the artifacts caused by autonomous movement and breathe, which has important application value in magnetic resonance animal model experiments.
[Keywords] 3D printing；magnetic resonance coil；magnetic resonance imaging；animal experimentation

ZHANG Jie Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

LI Jiali Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

SHEN Yaqi Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

WANG Qiuxia* Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

*Correspondence to: Wang QX, E-mail: guaiqiuqiu1981@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Fundamental Research Funds for the Central Universities No.2017KFYXJJ126 Teaching Project of Huazhong University of Science and Technology (HUST) No. 2017106
Received  2019-08-25
Accepted  2019-11-29
DOI: 10.12015/issn.1674-8034.2020.02.013
Cite this article as: Zhang J, Li JL, Shen YQ, et al. 3D printing technology improved animal coils to optimize KM mice magnetic resonance imaging study. Chin J Magn Reson Imaging, 2020, 11(2): 141-144. DOI:10.12015/issn.1674-8034.2020.02.013.

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