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• Clinical Article •
Characteristics of function of left executive control network in heroin addicts during methadone maintenance treatment: a resting-state fMRI study
JIN Long  ZHANG Wei  HUANG Yufang  WANG Lei  WEI Yixin  LI Yongbin  LIU Wei  LI Qiang  WANG Wei  WEI Longxiao 

Cite this article as: Jin L, Zhang W, Huang YF, et al. Characteristics of function of left executive control network in heroin addicts during methadone maintenance treatment: a resting-state fMRI study. Chin J Magn Reson Imaging, 2020, 11(3): 166-170. DOI:10.12015/issn.1674-8034.2020.03.002.


[Abstract] Objective: To investigate the characteristics of functional connectivity of left executive control network in heroin addicts during methadone maintenance treatment (MMT).Materials and Methods: Twenty-one heroin addicts during MMT (MMT group) and 20 healthy control subjects matched with age, sex and education level (HC group) were included in the resting-state functional magnetic resonance imaging (fMRI) study using 3.0 T magnetic resonance equipment. First of all, the functional connectivity of the whole brain were calculated based on the region of interest of the left executive control network, and the differences in functional connectivity of the left executive control network between the MMT group and HC group were analyzed. The correlation between the functional connectivity value of the different area and the history of heroin use and methadone treatment was further analyzed in MMT group.Results: The functional connectivity of the left executive control network of heroin addicts in MMT was stronger than that of the healthy subjects. The functional connectivity between the left dorsolateral prefrontal cortex and bilateral dorsolateral prefrontal cortex was enhanced (P< 0.05, corrected with GRF), and the functional connectivity between the left posterior parietal cortex and the left postcentral gyrus was enhanced. (P<0.05, corrected with GRF). The functional connectivity strength in the above areas was not correlated with the history of heroin use and methadone treatment in MMT group (P>0.05 respectively).Conclusions: The enhanced functional connectivity between the left lateral dorsal prefrontal cortex and bilateral dorsal lateral prefrontal cortex of heroin addicts during MMT may suggest that methadone can help improve the brain's executive control function and reduce the risk of relapse in heroin addicts. The enhanced functional connectivity between the left posterior parietal cortex and the postcentral gyrus might be a sign of abnormal adaptation to drug related cues due to long-term use of heroin.
[Keywords] heroin dependence；methadone maintenance treatment；executive control network；magnetic resonance imaging；functional connectivity

JIN Long Nuclear Medicine Department of Tangdu Hospital, Air Force Military Medical University, Xi'an, 710038, China

ZHANG Wei Nuclear Medicine Department of Tangdu Hospital, Air Force Military Medical University, Xi'an, 710038, China

HUANG Yufang Radiology Department of The First Naval Hospital of Southern Theater Command, Zhanjiang 524009, China

WANG Lei Nuclear Medicine Department of Tangdu Hospital, Air Force Military Medical University, Xi'an, 710038, China

WEI Yixin Nuclear Medicine Department of Tangdu Hospital, Air Force Military Medical University, Xi'an, 710038, China

LI Yongbin Radiology Department of The Second Affliated Hospital of Xi'an Medical College, Xi'an, 710038, China

LIU Wei Radiology Department of Tangdu Hospital, Air Force Military Medical University, Xi'an 710038, China

LI Qiang Radiology Department of Tangdu Hospital, Air Force Military Medical University, Xi'an 710038, China

WANG Wei Nuclear Medicine Department of Tangdu Hospital, Air Force Military Medical University, Xi'an, 710038, China

WEI Longxiao* Nuclear Medicine Department of Tangdu Hospital, Air Force Military Medical University, Xi'an, 710038, China

*Correspondence to: Wei LX, E-mail: weilx3245@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foundation of China No. 81671661
Received  2019-12-10
Accepted  2020-02-12
DOI: 10.12015/issn.1674-8034.2020.03.002
Cite this article as: Jin L, Zhang W, Huang YF, et al. Characteristics of function of left executive control network in heroin addicts during methadone maintenance treatment: a resting-state fMRI study. Chin J Magn Reson Imaging, 2020, 11(3): 166-170. DOI:10.12015/issn.1674-8034.2020.03.002.

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