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• Clinical Article •
Whole-tumor histogram analysis of enhanced T1-weighted images for differentiating diagnosis meningioma from choroid plexus papilloma in ventricle
ZHANG Rui  BAI Yan  WEI Wei  LIN Ruijuan  WANG Meiyun 

Cite this article as: Zhang R, Bai Y, Wei W, et al. Whole-tumor histogram analysis of enhanced T1-weighted images for differentiating diagnosis meningioma from choroid plexus papilloma in ventricle. Chin J Magn Reson Imaging, 2020, 11(3): 171-176. DOI:10.12015/issn.1674-8034.2020.03.003.


[Abstract] Objective: To investigate the features of whole-tumor histogram derived from enhanced T1-weighted images and its value in identification of meningioma from choroid plexus papilloma in ventricle.Materials and Methods: Retrospectively collected data from pathologically confirmed 33 cases of meningioma and 24 cases of choroid plexus papilloma from November 2009 to November 2019, preoperative routine enhanced MRI scanning were performed. The histogram features of two groups tumor parenchyma regions were extracted by MaZda software on the enhanced T1 weighted imaging axial images, and the gray histogram was performed. Statistical analysis was carried out on the obtained 9 histogram characteristic parameters of mean, variance, kurtosis, skewness, 1st percentile, 10th percentile, 50th percentile, 90th percentile and 99th percentile, so as to compare the characteristic differences between the meningioma and the choroid plexus papilloma. The receiver operating characteristic curve was established and the area under curve was calculated, the binary logistic regression analysis was used to combine the two parameters with larger area under the curve and establish the receiver operating characteristic curve to analyze the differential diagnostic performance of single histogram characteristic parameters and combined variable in meningioma and choroid plexus papilloma.Results: Among the 9 extracted histogram parameters, there were statistical differences between meningioma and choroid plexus papilloma in mean, kurtosis, 1st percentile, 10th percentile, and 50th percentile (all P<0.05), the calculated areas under receiver operating characteristic curve were 0.73, 0.77, 0.75, 0.78, 0.72, respectively. There were no significant differences in histogram parameters variance, skewness, 90th percentile and 99th percentile (all P>0.05). The 10th percentile and Kurtosis had higher diagnostic efficiency, with the optimal threshold for 112.40 and 0.63, the sensitivity and specificity of differential diagnosis were 66.70% and 91.70%, 72.70 and 87.50%, respectively. The combination of the two parameters had the highest diagnostic efficiency, the area under the curve was 0.88, the sensitivity and specificity were 87.50% and 81.80%, respectively.Conclusions: Whole-tumor histogram analysis of enhanced T1 weighted images could provide more quantitative information for the differential diagnosis of meningioma and choroid plexus papilloma in ventricle, with the 10th percentile and kurtosis being more diagnostic. The diagnosis efficiency of two-parameter combined may be further improved, which will provide more valuable references for the clinic.
[Keywords] meningioma；choroid plexus neoplasms；cerebral ventricles；magnetic resonance imaging

ZHANG Rui Department of Medical Imaging, the People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou 450003, China; Henan Provincial People's Hospital, Henan Key Laboratory of Neurological Imaging, Zhengzhou 450003, China; Academy of Medical Sciences, Zhengzhou University, Zhengzhou 450000, China

BAI Yan Department of Medical Imaging, the People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou 450003, China; Henan Provincial People's Hospital, Henan Key Laboratory of Neurological Imaging, Zhengzhou 450003, China

WEI Wei Department of Medical Imaging, the People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou 450003, China; Henan Provincial People's Hospital, Henan Key Laboratory of Neurological Imaging, Zhengzhou 450003, China

LIN Ruijuan Academy of Medical Sciences, Zhengzhou University, Zhengzhou 450000, China

WANG Meiyun* Department of Medical Imaging, the People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou 450003, China; Henan Provincial People's Hospital, Henan Key Laboratory of Neurological Imaging, Zhengzhou 450003, China

*Correspondence to: Wang MY, E-mail: marian9999@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This article is supported by the National Key Research and Development Program of China No. 2017YFE0103600 National Natural Science Foundation of China No. 81601466, 81720108021 Zhongyuan Thousand Talents Plan Project--Zhongyuan Leader Talent No. ZYQR201810117 Program for Science and Technology Development of Henan Province No. 182102310496 Program for Medical Science and Technology Development of Henan Province No. 2018020403
Received  2019-10-22
Accepted  2020-02-12
DOI: 10.12015/issn.1674-8034.2020.03.003
Cite this article as: Zhang R, Bai Y, Wei W, et al. Whole-tumor histogram analysis of enhanced T1-weighted images for differentiating diagnosis meningioma from choroid plexus papilloma in ventricle. Chin J Magn Reson Imaging, 2020, 11(3): 171-176. DOI:10.12015/issn.1674-8034.2020.03.003.

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