• Clinical Article •
The value of magnetic resonance spectroscopy in thalamic region of patients with Parkinson's disease
Cite this article as: Yang F, Wang H, Ma JX, et al. The value of magnetic resonance spectroscopy in thalamic region of patients with Parkinson's disease. Chin J Magn Reson Imaging, 2020, 11(3): 183-189. DOI:10.12015/issn.1674-8034.2020.03.005.
| [Abstract] Objective: Multivoxel magnetic resonance spectroscopy was used to study the changes of metabolites in thalamus of patients with Parkinson's disease. The correlation between MRS ratio in thalamus and clinical Hoehn & Yahr rating scale and Unified Parkinson's disease Rating Scale in patients with PD was investigated.Materials and Methods: Thirty patients with PD and 24 age and sex matched volunteers were divided into PD group and control group. Thirty patients in PD group were treated with H-Y grade and UPDRS score. Philips Achieva TX 3.0 T MR imaging system was used to detect the bilateral thalamic regions of the subjects, and the corresponding metabolite ratio and spectral line information were obtained. To investigate the relationship between the ratio of MRS in thalamic area and clinical H-Y grade in PD group, and to compare the correlation between MRS ratio and UPDRS scale.Results: (1) The difference of NAA/Cr, Cho/Cr and NAA/Cho between the left and right thalamus in the control group was not significant (P>0.05), and the significant difference of NAA/Cr and Cho/Cr was found between the severe side of the PD group and the contralateral thalamus (P< 0.05). (2) The value of NAA/Cr and NAA/Cho in the severe thalamic region of PD group, and the contralateral NAA/Cr value was significantly lower than that of the control group (P< 0.05). (3) There were significant differences in the ratio of symptomatic NAA/Cr, NAA/Cho and contralateral NAA/Cr in the control group, early, middle and late Parkinson's disease. Further multiple comparisons showed that there was significant difference in the severity of NAA/Cr in patients with PD. Spearman correlation analysis showed that there was a strong negative correlation between NAA/Cr value and H-Y grade in the severe thalamic region of PD patients. There was a moderate negative correlation between NAA/Cho value in severe thalamic area, NAA/Cr value and Cho/Cr value in contralateral thalamic area and H-Y grade. (4) Pearson correlation analysis showed that there was a strong negative correlation between NAA/Cr value and UPDRS score in the symptomatic thalamic area of PD patients, and a moderate negative correlation between NAA/Cho value and UPDRS score. There was a negative correlation between the contralateral NAA/Cr value and the Cho/Cr value and the UPDRS score.Conclusions: 1H-MRS can noninvasively detect the decrease of nerve function in thalamic area and is closely related to the asymmetrical progress of symptoms and signs of Parkinson's disease, which can provide a certain basis for the diagnosis of Parkinson's disease. There is a certain correlation between the ratio of MRS related metabolites and H-Ygrade and UPDRS score, which plays an auxiliary role in reflecting the severity and stage of the disease. |
| [Keywords] Parkinson disease；thalamus；proton magnetic resonance spectroscopy |
YANG Fan Department of Radiology, the Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830028, China
WANG Hong* Department of Radiology, the Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830028, China
MA Jingxu Department of Radiology, the Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830028, China
LIU Ying Department of Radiology, the Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830028, China
JIANG Lei Department of Radiology, the Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830028, China
ZHANG Xiaobin Department of Radiology, the Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830028, China
*Correspondence to: Wang H, E-mail: wangh_xj@163.com
Conflicts of interest None.
| ACKNOWLEDGMENTS Natural Science Foundation of Xinjiang Uygur Autonomous region No. 2019D01C227 |
| Received 2019-11-05 |
| Accepted 2020-02-12 |
| DOI: 10.12015/issn.1674-8034.2020.03.005 |
| Cite this article as: Yang F, Wang H, Ma JX, et al. The value of magnetic resonance spectroscopy in thalamic region of patients with Parkinson's disease. Chin J Magn Reson Imaging, 2020, 11(3): 183-189. DOI:10.12015/issn.1674-8034.2020.03.005. |
[1]
Kim Y, Choi Y. A Cross-language study of acoustic predictors of speech intelligibility in individuals with Parkinson's Disease. J Speech Lang Hear Res, 2017, 60(9): 1-13.
[2]
Hughes AJ, Daniel SE, Kilford L, et al. Accuracy of clinical diagnosis of idiopathic Parkinson\"s disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry, 1992, 55(3): 181-184.
[3]
Dipasquale S, Meroni R, Sasanelli F, et al. Physical therapy versus a general exercise programme in patients with Hoehn Yahr Stage II Parkinson's disease: a randomized controlled trial. J Parkinson' s Dis, 2017, 7(1): 203-210.
[4]
沈吉康，叶民，刘卫国，等．帕金森病非运动症状的临床研究．临床神经病学杂志, 2010, (4): 17-19.
[5]
Camilleri A, Vassallo N. The centrality of mitochondria in the pathogenesis and treatment of Parkinson' s disease. CNS Neurosci Therap, 2014, 20(7): 591-602.
[6]
Rodríguez-Violante M, Cervantes-Arriaga A, González-Latapí P, et al. Proton magnetic resonance spectroscopy changes in Parkinson's disease with and without psychosis. Revista De Investigacion Clin, 2015, 67(4): 227-234.
[7]
Reimão S, Pita LP, Neutel D, et al. Substantia nigra neuromelanin magnetic resonance imaging in de novo Parkinson's disease patients. Eur J Neurol, 2015, 22(3): 540-546.
[8]
Guan J, Rong Y, Wen Y, et al. Detection and application of neurochemical profile by multiple regional 1H-MRS in Parkinson's disease. Brain Behav, 2017, 7(9): 792-795.
[9]
Weiduschat N, Mao X, Beal MF, et al. Usefulness of proton and phosphorus MR spectroscopic imaging for early diagnosis of Parkinson's disease. J Neuroimaging, 2015, 25(1): 105-110.
[10]
Kalia LV, Lang DAE. Parkinson's disease. Lancet, 2015, 386(9996): 896-912.
[11]
Baik HM, Choe BY, Lee HK, et al. Metabolic alterations in Parkinson's disease after thalamotomy, as revealed by 1H MR spectroscopy. Korean J Radiol, 2002, 3(3): 180-188.
[12]
Zhou B, Yuan F, He Z, et al. Application of proton magnetic resonance spectroscopy on substantia nigra metabolites in Parkinson' s disease. Brain Imaging Behav, 2014, 8(1): 97-101.
[13]
侯文尚．豆状核及丘脑N-乙酰天门冬氨酸含量与帕金森病的关系研究．南昌：南昌大学, 2016.
[14]
Wu G, Shen YJ, Huang MH, et al. Proton MR spectroscopy for monitoring pathologic changes in the substantia nigra and globus pallidus in Parkinson disease. Am J of Roentgenol, 2016, 206(2): 385-389.
[15]
付蓉，李德炯，赵晶，等．磁共振波谱分析在帕金森病诊断中的临床应用．第三军医大学学报, 2014, 36(19): 2055-2056.
[16]
Geng DY, Li YX, Zee CS. Magnetic resonance imaging-based volumetric analysis of basal ganglia nuclei and substantia Nigra in patients with Parkinson' s disease. Neurosurgery, 2006, 58(2): 256-262.
[17]
Abe K. Proton magnetic resonance spectroscopy of patients with parkinsonism. Brain Res Bulletin, 2000, 52(6): 589-595.
