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• Clinical Article •
The value of magnetic resonance spectroscopy in thalamic region of patients with Parkinson's disease
YANG Fan  WANG Hong  MA Jingxu  LIU Ying  JIANG Lei  ZHANG Xiaobin 

Cite this article as: Yang F, Wang H, Ma JX, et al. The value of magnetic resonance spectroscopy in thalamic region of patients with Parkinson's disease. Chin J Magn Reson Imaging, 2020, 11(3): 183-189. DOI:10.12015/issn.1674-8034.2020.03.005.


[Abstract] Objective: Multivoxel magnetic resonance spectroscopy was used to study the changes of metabolites in thalamus of patients with Parkinson's disease. The correlation between MRS ratio in thalamus and clinical Hoehn & Yahr rating scale and Unified Parkinson's disease Rating Scale in patients with PD was investigated.Materials and Methods: Thirty patients with PD and 24 age and sex matched volunteers were divided into PD group and control group. Thirty patients in PD group were treated with H-Y grade and UPDRS score. Philips Achieva TX 3.0 T MR imaging system was used to detect the bilateral thalamic regions of the subjects, and the corresponding metabolite ratio and spectral line information were obtained. To investigate the relationship between the ratio of MRS in thalamic area and clinical H-Y grade in PD group, and to compare the correlation between MRS ratio and UPDRS scale.Results: (1) The difference of NAA/Cr, Cho/Cr and NAA/Cho between the left and right thalamus in the control group was not significant (P>0.05), and the significant difference of NAA/Cr and Cho/Cr was found between the severe side of the PD group and the contralateral thalamus (P< 0.05). (2) The value of NAA/Cr and NAA/Cho in the severe thalamic region of PD group, and the contralateral NAA/Cr value was significantly lower than that of the control group (P< 0.05). (3) There were significant differences in the ratio of symptomatic NAA/Cr, NAA/Cho and contralateral NAA/Cr in the control group, early, middle and late Parkinson's disease. Further multiple comparisons showed that there was significant difference in the severity of NAA/Cr in patients with PD. Spearman correlation analysis showed that there was a strong negative correlation between NAA/Cr value and H-Y grade in the severe thalamic region of PD patients. There was a moderate negative correlation between NAA/Cho value in severe thalamic area, NAA/Cr value and Cho/Cr value in contralateral thalamic area and H-Y grade. (4) Pearson correlation analysis showed that there was a strong negative correlation between NAA/Cr value and UPDRS score in the symptomatic thalamic area of PD patients, and a moderate negative correlation between NAA/Cho value and UPDRS score. There was a negative correlation between the contralateral NAA/Cr value and the Cho/Cr value and the UPDRS score.Conclusions: 1H-MRS can noninvasively detect the decrease of nerve function in thalamic area and is closely related to the asymmetrical progress of symptoms and signs of Parkinson's disease, which can provide a certain basis for the diagnosis of Parkinson's disease. There is a certain correlation between the ratio of MRS related metabolites and H-Ygrade and UPDRS score, which plays an auxiliary role in reflecting the severity and stage of the disease.
[Keywords] Parkinson disease；thalamus；proton magnetic resonance spectroscopy

YANG Fan Department of Radiology, the Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830028, China

WANG Hong* Department of Radiology, the Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830028, China

MA Jingxu Department of Radiology, the Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830028, China

LIU Ying Department of Radiology, the Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830028, China

JIANG Lei Department of Radiology, the Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830028, China

ZHANG Xiaobin Department of Radiology, the Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830028, China

*Correspondence to: Wang H, E-mail: wangh_xj@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  Natural Science Foundation of Xinjiang Uygur Autonomous region No. 2019D01C227
Received  2019-11-05
Accepted  2020-02-12
DOI: 10.12015/issn.1674-8034.2020.03.005
Cite this article as: Yang F, Wang H, Ma JX, et al. The value of magnetic resonance spectroscopy in thalamic region of patients with Parkinson's disease. Chin J Magn Reson Imaging, 2020, 11(3): 183-189. DOI:10.12015/issn.1674-8034.2020.03.005.

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