• Review •
Value of the central vein sign in multiple sclerosis
Cite this article as: Minawaer•Yimiti, Mayinuer•Maimaiti. Value of the central vein sign in multiple sclerosis. Chin J Magn Reson Imaging, 2020, 11(3): 232-234. DOI:10.12015/issn.1674-8034.2020.03.016.
| [Abstract] The diagnosis of multiple sclerosis (MS) is often difficult, timely and correct diagnosis plays an important role in the early treatment and prognosis of the disease.In multiple sclerosis, magnetic resonance imaging (MRI) is a sensitive tool for detecting white matter lesions, but its diagnostic specificity is still suboptimal; ambiguous cases are frequent in clinical practice. Detection of perivenular lesions in the brain (the "central vein sign, CVS" ) improves the pathological specificity of MS diagnosis, and the discovery of central vein sign is expected to be a marker for the diagnosis of MS. Recent studies have demonstrated that the CVS may have the ability to accurately differentiateMSfrom its mimics. This review will systematically analyze the characteristics of CVS of MRI and its role in the diagnosis and differentiation of MS to provide important clues for the clinical diagnosis of MS. |
| [Keywords] central vein sign；magnetic resonance imaging；multiple sclerosis |
Minawaer• Yimiti Xinjiang Medical University, Urumqi 830001, China
Mayinuer• Maimaiti* Xinjiang People's Hospital, Neurology department, Urumqi 830001, China
*Corresponding to: Mayinuer•Maimaiti, E-mail: maiynur2@163.com
Conflicts of interest None.
| Received 2019-09-12 |
| Accepted 2020-02-12 |
| DOI: 10.12015/issn.1674-8034.2020.03.016 |
| Cite this article as: Minawaer•Yimiti, Mayinuer•Maimaiti. Value of the central vein sign in multiple sclerosis. Chin J Magn Reson Imaging, 2020, 11(3): 232-234. DOI:10.12015/issn.1674-8034.2020.03.016. |
[1]
张华，侯世芳，殷剑．磁共振中央静脉征对多发性硬化诊断的意义．中国神经免疫学和神经病学杂志, 2017, 24(2): 92-93.
[2]
Lublin F, Reingold S, Cohen J, et al. Defining the clinical course of multiple sclerosis. Neurology, 2014, 15, 83(3): 278-286.
[3]
尹平，曾春，王静杰，等．复发缓解型多发性硬化患者脑内病灶动态对比增强MRI灌注及渗透特点．中华放射学杂志, 2015, 49(10): 731-735.
[4]
Filippi M, Rocca MA, Ciccarelli O. et al. MRI criteria for the diagnosis of multiple sclerosis: MAGNIMS consensus guidelines. Lancet Neurol, 2016, 15(3): 292-303.
[5]
Solomon AJ, Klein EP, Bourdette D, et al. "Undiagnosing" multiple sclerosis: the challenge of misdiagnosis in MS. Neurology, 2012, 78(24): 1986-1991.
[6]
Solomon AJ, Bourdette DN, Cross AH, et al. The contemporary spectrum of multiple sclerosis misdiagnosis: a multicenter study. Neurology, 2016, 87(13): 1393-1399.
[7]
Dworkin JD, Sati P, Solomon A, et al. Automated integration of multimodal MRI for the probabilistic detection of the central vein sign in white matter lesions. AJNR Am J Neuroradiol, 2018, 39(10): 1806-1813.
[8]
Sparacia G, Agnello F, Gambino A, et al. Multiple sclerosis: high prevalence of the 'central vein’ sign in white matter lesions on susceptibility weighted images. Neuroradiol J, 2018, 31(4): 356-361.
[9]
Suthiphosuwan S, Sati P, Guenette M, et al. The central vein sign in radiologically isolated syndrome. AJNR Am J Neuroradiol, 2019, 40(5): 776-783.
[10]
Dworkin JD, Sati P, Solomon A, et al. Automated integration of multimodal MRI for the probabilistic detection of the central vein sign in white matter lesions. AJNR Am J Neuroradiol, 2018, 39(10): 1806-1813.
[11]
Tallantyre EC, Dixon JE, Donaldson I, et al. Ultra-high-field imaging distinguishesMSlesions from asymptomatic white matter lesions. Neurology, 2011, 76(6): 534-539.
[12]
Solomon AJ, Klein EP, Bourdette D. "Undiagnosing" multiple sclerosis: the challenge of misdiagnosis in MS. Neurology, 2012, 78(24): 1986-1991.
[13]
Solomon AJ, Bourdette DN, Applebee A, et al. The contemporary spectrum of multiple sclerosis misdiagnosis: a multicenter study. Neurology, 2016, 87(13): 1393-1399.
[14]
Aaron E, Miller AE, Peter A, et al. Central vein sign in multiple sclerosis ready for front and center. Neurology, 2018, 90(14): 631-632.
[15]
George IC, Sati P, Absinta M, et al. Clinical 3-tesla FLAIR* MRI improves diagnostic accuracy in multiple sclerosis. Mult Scler J, 2016, 22(22): 1578-1576.
[16]
Sati P, Oh J, Constable RT, et al. The central vein sign and its clinical evaluation for the diagnosis of multiple sclerosis: a consensus statement from the North American Imaging in Multiple Sclerosis Cooperative. Nat Rev Neurol, 2016, 12(12): 714-722.
[17]
Solomon AJ, Schindler MK, Howard DB, et al. Central vessel sign on 3 T FLAIR* MRI for the differentiation of multiple sclerosis from migraine.Ann Clin Transl Neurol. 2015, 16, 3(2): 82-87.
[18]
George IC, Sati P, Absinta M, et al. Clinical 3-tesla FLAIR* MRI improves diagnostic accuracy in multiple sclerosis. Mult Scler J, 2016, 22(12): 1578-1576.
[19]
Tallantyre EC, Dixon JE, Donaldson I, et al. Ultra-high-field imaging distinguishesMSlesions from asymptomatic white matter lesions. Neurology, 2011, 76(6): 534-539.
[20]
Kilsdonk ID, Wattjes MP, Lopez-Soriano A, et al. Improved differentiation betweenMSand vascular brain lesions using FLAIR* at 7 Tesla. Eur Radiol, 2014, 24(4): 841-849.
[21]
Mistry N, Abdel-Fahim R, Samaraweera A, et al. Imaging central veins in brain lesions with 3-T T2*-weighted magnetic resonance imaging differentiates multiple sclerosis from microangiopathic brain lesions. Mult Scler, 2016, 22(10): 1289-1296.
[22]
Solomon AJ, Schindler MK, Howard DB, et al. "Central vessel sign" on 3T FLAIR * MRI for the differentiation of multiple sclerosis from migraine. Ann Clin Transl Neurol, 2015, 3(2): 82-87.
[23]
Cortese R, Magnollay L, Tur C, et al. Value of the central vein sign at 3 T to differentiateMSfrom seropositive NMOSD. Neurology, 2018, 90(14): 1183-1190.
[24]
Lummel N, Boeckh-Behrens T, Schoepf V, et al. Presence of a central vein within white matter lesions on susceptibility weighted imaging: a specific finding for multiple sclerosis? Neuroradiology, 2011, 53(5): 311-317.
[25]
Samaraweera AP, Falah Y, Pitiot A, et al. The MRI central vein marker, differentiating PPMS from RRMS and ischemic SVD. Neurol Neuroimmunol Neuroinflamm, 2018, 5(6): e496.
[26]
Wuerfel J, Sinnecker T, Ringelstein EB, et al. Lesion morphology at 7 Tesla MRI differentiates Susac syndrome from multiple sclerosis. Mult Scler, 2012, 18(11): 1592-1599.
[27]
Suthiphosuwan SL, Sati P, Guenette M, et al. The central vein sign in radiologically isolated syndrome. AJNR Am J Neuroradiol, 2019, 40(5): 776-783.
