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• Clinical Article •
Investigation of intracerebral enlarged perivascular space in cognitive impairment groups with different severity
FU Qingyang  LI Yuehua  HUANG Lin  GUO Qihao 

Cite this article as: Fu QY, Li YH, Huang L, et al. Investigation of intracerebral enlarged perivascular space in cognitive impairment groups with different severity. Chin J Magn Reson Imaging, 2020, 11(4): 241-245. DOI:10.12015/issn.1674-8034.2020.04.001.


[Abstract] Objective: To investigate the intracerebral enlarged perivascular spaces (EPVS) in middle-aged and old people from community among cognitive impairment groups with different severity, and to analyze the relationship between EPVS and cognitive function.Materials and Methods: 48 people with subjective cognitive decline (SCD), 43 people with amnestic mild cognitive impairment (aMCI), 44 people with Alzheimer’s disease (AD) and 43 normal controls (NC) were included in the study. Multiple neuropsychological tests and multi-modal magnetic resonance imaging were conducted. EPVS in the basal ganglia and centrum semiovale were counted and graded from 0 to 4. Kruskal-Wallis test and Kolmogorov- Smirnov Z test were used to analyze the inter-group difference. Relationship between the scores of EPVS and cognitive function were analyzed using Spearman’s Correlation analyses and partial correlation.Results: EPVS was shown in all the examinees. EPVS score in AD group (3.18±0.58) was significantly higher than that in SCD group (2.60±0.64)(P< 0.01), aMCI group (2.77±0.81)(P<0.05) and NC group (2.56±0.77)(P<0.01). PVS score were positively associated with age (P<0.05). After controlling age, gender and years of education, the partial correlation result showed that PVS scores in the centrum semiovale were negatively correlated with MMSE, MoCA-B (r=-0.30,-0.37, P=0.000), were negatively correlated with AVLT-N5, N7 scores (r=-0.241, P=0.002; r=-0.275, P=0.000), were significantly negatively associated with BNT scores (r=-0.257, P=0.001). However, no difference was found in EVPS in the basal ganglia.Conclusions: The EPVS in the centrum semiovale of AD group increases. EPVS in the centrum semiovale is negatively correlated with overall cognitive function, memory and language functions.
[Keywords] Alzheimer’s disease；cognitive disorder；perivascular spaces；magnetic resonance imaging

FU Qingyang Department of Radiology, the Sixed Hospital, Shanghai Jiaotong University, ShangHai 200233, China

LI Yuehua* Department of Radiology, the Sixed Hospital, Shanghai Jiaotong University, ShangHai 200233, China

HUANG Lin Department of Geriatrics, the Sixed Hospital, Shanghai Jiaotong University, ShangHai 200233, China

GUO Qihao Department of Geriatrics, the Sixed Hospital, Shanghai Jiaotong University, ShangHai 200233, China

*Correspondence to: Li YH, E-mail: liyuehua312@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foundation of China No. 81871329 National Key Research and Development Program of China No. 2016YFC1306305 Excellent Discipline Leader of Shanghai Municipal Planning Commission No. 2017BR041
Received  2020-01-16
Accepted  2020-02-25
DOI: 10.12015/issn.1674-8034.2020.04.001
Cite this article as: Fu QY, Li YH, Huang L, et al. Investigation of intracerebral enlarged perivascular space in cognitive impairment groups with different severity. Chin J Magn Reson Imaging, 2020, 11(4): 241-245. DOI:10.12015/issn.1674-8034.2020.04.001.

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