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• Clinical Article •
Resting state amplitude of low-frequency fluctuation alterations of mild cognitive impairment in patients with multiple system atrophy
LI Yingmei  YANG Huaguang  FAN Guoguang 

Cite this article as: Li YM, Yang HG, Fan GG. Resting state amplitude of low-frequency fluctuation alterations of mild cognitive impairment in patients with multiple system atrophy. Chin J Magn Reson Imaging, 2020, 11(4): 246-252. DOI:10.12015/issn.1674-8034.2020.04.002.


[Abstract] Objective: To investigate cognitive-related changes of spontaneous activity in multiple system atrophy (MSA) patients using amplitude of low-frequency fluctuation (ALFF) approach.Materials and Methods: Resting state functional magnetic resonance imaging (rs-fMRI) data were selected from 29 MSA patients with normal cognitive function (PD-NC), 33 MSA patients with mild cognitive impairment (PD-MCI), and 33 healthy controls (HC). ALFF changes were compared between subgroups. Spearman correlation test was taken between patients' ALFF values of changed brain regions and montreal cognitive assessment scale (MoCA) scores.Results: Compared to HC, MSA-NC showed increased ALFF in left angular gyrus and right middle temporal gyrus (MTG). MSA-MCI showed decreased ALFF in bilateral ventral prefrontal cortex (VLPFC), dorsolateral prefrontal cortex (DLPFC), anterior and middle cingulum cortex (ACC, MCC) compared to HC, while it showed increased ALFF in bilateral inferior temporal gyrus (ITG), angular gyrus, left middle occipital gyrus, right middle temporal gyrus (MTG), precuneus, right cerebellum and vermis in the same comparison. Compared to MSA-NC, MSA-MCI showed decreased ALFF in right frontal lobe and increased ALFF in right cerebellum. In addition, MSA patients' ALFF values in right frontal lobe were positively correlated with MoCA scores (r=0.531, P<0.05), while the correlation was negative in the right cerebellum (r=-0.449, P<0.05).Conclusions: Functional damage in frontal lobe and cerebellum are associated with MSA specific mild cognitive impairment, and the cerebellum may play a compensatory role.
[Keywords] multiple system atrophy；mild cognitive impairment；functional magnetic resonance imaging；amplitude of low-frequency fluctuation

LI Yingmei Department of Radiology, the First Hospital of China Medical University, Shenyang 110001, China

YANG Huaguang Department of Radiology, the First Hospital of China Medical University, Shenyang 110001, China

FAN Guoguang* Department of Radiology, the First Hospital of China Medical University, Shenyang 110001, China

*Correspondence to: Fan GG, E-mail: fanguog@sina.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Distinguished Professor Fund of Liaoning Province No. Liao Jiao Fa [2014]187
Received  2019-12-27
Accepted  2020-03-23
DOI: 10.12015/issn.1674-8034.2020.04.002
Cite this article as: Li YM, Yang HG, Fan GG. Resting state amplitude of low-frequency fluctuation alterations of mild cognitive impairment in patients with multiple system atrophy. Chin J Magn Reson Imaging, 2020, 11(4): 246-252. DOI:10.12015/issn.1674-8034.2020.04.002.

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