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• Clinical Article •
Preliminary study of brain resting state functional magnetic resonance local consistency analysis in patients with mild cognitive impairment
WEN Yu  LIU Bo  WANG Xiaochun 

Cite this article as: Wen Y, Liu B, Wang XC. Preliminary study of brain resting state functional magnetic resonance local consistency analysis in patients with mild cognitive impairment. Chin J Magn Reson Imaging, 2020, 11(4): 253- 258. DOI:10.12015/issn.1674-8034.2020.04.003.


[Abstract] Objective: To explore the characteristics of functional brain changes in patients with mild cognitive impairment (MCI) with regional homogeneity (ReHo), and further explore the relationship between the changes of ReHo value of corresponding brain regions and cognitive function and clinical physiological indicators.Materials and Methods: A total of 39 subjects were collected, including 17 MCI patients and 22 healthy volunteers with matching age, gender, and education years. All subjects were subjected to resting-state functional magnetic resonance imaging (rs-fMRI) scan, using the ReHo analysis method, to compare the resting brain area between MCI patients and healthy volunteers in the resting state. Then extract the significant differences in ReHo values of brain regions and cognitive assessment scale and clinical physiological indicators for correlation analysis.Results: Compared with healthy controls, MCI showed significantly decreased ReHo values in right insula/fusiform gyrus, left cerebellar hemisphere/paracingulate cortex/inferior frontal gyrus/fusiform gyrus, while increased ReHo values in left superior temporal gyrus and right superior frontal gyrus. The montreal cognitive assessment scale (MoCA) were inversely correlated with the ReHo values of right insula (r= -0.487, P=0.002), and positively correlated with the ReHo values of left superior temporal gyrus (r=0.610, P<0.001) and right dorsal lateral frontal gyrus (r=0.475, P=0.002) in all subjects. The mini mental status examination (MMSE) were inversely correlated with the ReHo values of upper left cerebellum (r=-0.407, P=0.010), and positively correlated with the ReHo values of left superior temporal gyrus (r=0.466, P=0.003) in all subjects. Furthermore, the ReHo values of right insula were inversely correlated with the fructosamine concentrations in the blood plasma (r=-0.630, P=0.007) and the ReHo values of left cerebellar hemispherehave negative correlation with serum creatinine concentration (r=-0.579, P=0.015) in MCI.Conclusions: The ReHo value of rs-fMRI in patients with MCI was significantly changed, and there was a certain correlation with changes in cognitive function and clinical physiological data.
[Keywords] mild cognitive impairment；functional magnetic resonance imaging；regional homogeneity；brain

WEN Yu Department of Medical Imaging, Shanxi Medical University, Taiyuan 030001, China

LIU Bo Department of Medical Imaging, Shanxi Medical University, Taiyuan 030001, China

WANG Xiaochun* Department of Radiology, First Clinical Medical College, Shanxi Medical University, Taiyuan 030001, China

*Correspondence to: Wang XC, E-mail: 2010xiaochun@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Scientific and Technological Project of Shanxi Province No.20130313020-5
Received  2019-12-23
Accepted  2020-03-16
DOI: 10.12015/issn.1674-8034.2020.04.003
Cite this article as: Wen Y, Liu B, Wang XC. Preliminary study of brain resting state functional magnetic resonance local consistency analysis in patients with mild cognitive impairment. Chin J Magn Reson Imaging, 2020, 11(4): 253- 258. DOI:10.12015/issn.1674-8034.2020.04.003.

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