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• Clinical Article •
Early brain overgrowth in children with autism spectrum disorders based on structural magnetic resonance imaging
LIU Yang  ZHU Zhijun  CAO Manrui  LIU Bingguang  GUO Jimin  WAN Guobin 

Cite this article as: Liu Y, Zhu ZJ, Cao MR, et al. Early brain overgrowth in children with autism spectrum disorders based on structural magnetic resonance imaging. Chin J Magn Reson Imaging, 2020, 11(4): 264-269. DOI:10.12015/issn.1674-8034.2020.04.005.


[Abstract] Objective: Autism spectrum disorders (ASD) is a severe and pervasive neurodevelopmental disorder. At present, the etiology of ASD is still an unsolved problem in the world of medicine, and remains poorly understood. In this study, regional features extracted by structural magnetic resonance imaging were used to study brain dysplasia in ASD.Materials and Methods: This study investigates brain developmental abnormalities in patients with ASD by utilizing regional features extracted from structural magnetic resonance imaging (sMRI). Regional features include cerebral cortex thickness, gray matter and white matter region volume, and several subcortical structures extracted from a predefined regions of interest (ROI).Results: Through the analysis of 150 items of cerebral cortex and volume by t test, this study found that there were significant differences in 66 items among children with ASD and the normal control group (P<0.05), and the brains of children with ASD showed significant patterns of excessive growth compared with older, normal-developing children, especially in the parietal, occipital, frontal, temporal and precuneus region.Conclusions: This study confirms the existence of over-development of brain structure in children with ASD. Increased brain size is an important structural feature of early brain development in children with ASD, which will provide a powerful tool for the early diagnosis and assessment of ASD.
[Keywords] autism spectrum disorders；magnetic resonance imaging；excessive growth；cerebral cortex

LIU Yang Department of Radiology, Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, Shenzhen 518028, China

ZHU Zhijun* Department of Radiology, Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, Shenzhen 518028, China

CAO Manrui Department of Radiology, Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, Shenzhen 518028, China

LIU Bingguang Department of Radiology, Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, Shenzhen 518028, China

GUO Jimin Department of Radiology, Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, Shenzhen 518028, China

WAN Guobin Department of Children Psychology, Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, Shenzhen 518028, China

*Correspondence to: Zhu ZJ, E-mail: zhuzhijun72@126.com

Conflicts of interest   None.

Received  2019-12-13
Accepted  2020-03-13
DOI: 10.12015/issn.1674-8034.2020.04.005
Cite this article as: Liu Y, Zhu ZJ, Cao MR, et al. Early brain overgrowth in children with autism spectrum disorders based on structural magnetic resonance imaging. Chin J Magn Reson Imaging, 2020, 11(4): 264-269. DOI:10.12015/issn.1674-8034.2020.04.005.

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