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The value of DCE-MRI combined with DWI in differential diagnosis of breast benign and malignant diseases
WEN Jie  KANG Wenyan  LIU Zhou  LI Li  ZHONG Yihong  WANG Yunfei  LUO Dehong 

Cite this article as: Wen J, Kang WY, Liu Z, et al. The value of DCE-MRI combined with DWI in differential diagnosis of breast benign and malignant diseases. Chin J Magn Reson Imaging, 2020, 11(4): 304-307. DOI:10.12015/issn.1674-8034.2020.04.013.


[Abstract] Objective: To explore time-signal intensity curve (TIC) type, early enhancement rate and the value of apparent diffusion coefficient (ADC) in differential diagnosis of benign and malignant breast lesions.Materials and Methods: The preoperative magnetic resonance imaging and clinicopathological data of 140 pathologically confirmed breast lesions in our hospital from April 2017 to April 2019 were retrospectively analyzed. The lesions were divided into benign lesion group and malignant lesion group according to the pathology after operation. The difference of TIC curve type and early enhancement rate between benign and malignant breast lesions were compared and the difference of ADC value between the two groups was compared.Results: 140 lesions of 107 patients were included in the study. Three of them had breast cancer and breast fibroadenoma simultaneously, one had ipsilateral breast and two had bilateral breast respectively. 43 benign lesions, 97 lesions of malignant tumors. The TIC curve type, the type of early enhancement rate of benign and malignant breast lesions were significantly different (P<0.05). The average ADC value of benign lesions was (1.335±0.266)×10-3 mm2/s and that of malignant lesions was (0.965±0.215)×10-3 mm2/s. There was a significant difference between the two groups (P<0.05). When the threshold value of ADC was 1.085×10-3 mm2/s, the sensitivity, specificity, accuracy and area under the curve of ADC were 73.2%, 86.0%, 77.1% and 0.857 respectively. The sensitivity, specificity and accuracy of TIC curve, early enhancement rate and ADC were 83.5%, 79.1% and 78.5% respectively. The area under the curve of AUC was 0.882, which was higher than that under the curve of other three diagnostic methods (0.728, 0.562, 0.857).Conclusions: The combined diagnosis of ADC value of diffusion weighted imaging, semi-quantitative parameters of dynamic contrast-enhanced imaging (TIC curve type and early enhancement rate of the first stage) is of great value in differential diagnosis of benign and malignant breast lesions.
[Keywords] breast diseases；dynamic contrast-enhanced imaging；diffusion weighted imaging；magnetic resonance imaging

WEN Jie National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital& Shenzhen Hospital, Chinese Academy of Mediacal Sciences and Peking Union Medical College, Shenzhen 5180006, China

KANG Wenyan National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital& Shenzhen Hospital, Chinese Academy of Mediacal Sciences and Peking Union Medical College, Shenzhen 5180006, China

LIU Zhou National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital& Shenzhen Hospital, Chinese Academy of Mediacal Sciences and Peking Union Medical College, Shenzhen 5180006, China

LI Li National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital& Shenzhen Hospital, Chinese Academy of Mediacal Sciences and Peking Union Medical College, Shenzhen 5180006, China

ZHONG Yihong National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital& Shenzhen Hospital, Chinese Academy of Mediacal Sciences and Peking Union Medical College, Shenzhen 5180006, China

WANG Yunfei National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital& Shenzhen Hospital, Chinese Academy of Mediacal Sciences and Peking Union Medical College, Shenzhen 5180006, China

LUO Dehong* National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital& Shenzhen Hospital, Chinese Academy of Mediacal Sciences and Peking Union Medical College, Shenzhen 5180006, China; National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Mediacal Sciences and Peking Union Medical College, Beijing 100021, China

*Corresponding to: Luo DH, E-mail: cjr.luodehong@vip.163.com

Conflicts of interest   None.

Received  2019-11-19
Accepted  2019-12-31
DOI: 10.12015/issn.1674-8034.2020.04.013
Cite this article as: Wen J, Kang WY, Liu Z, et al. The value of DCE-MRI combined with DWI in differential diagnosis of breast benign and malignant diseases. Chin J Magn Reson Imaging, 2020, 11(4): 304-307. DOI:10.12015/issn.1674-8034.2020.04.013.

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