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• Clinical Article •
The application value of MRA, 3D-ASL and IVIM technology in TIA
LI Xuan  WU Jiang  YANG Zhaohui  ZHU Lina  NIU Heng  HAO Xiaoyong 

Cite this article as: Li X, Wu J, Yang ZH, et al. The application value of MRA, 3D-ASL and IVIM technology in TIA. Chin J Magn Reson Imaging, 2020, 11(5): 321-325. DOI:10.12015/issn.1674-8034.2020.05.001.


[Abstract] Objective: To evaluate the value of magnetic resonance angiography (MRA), three-dimensional arterial spin labeling (3D-ASL) and intravoxel incoherent motion imaging (IVIM) in transient ischemic attack (TIA).Materials and Methods: Fifty-two patients with clinically diagnosed TIA underwent multi-modal MRI scans including DWI, MRA, 3D-ASL (PLD=1.5 s) and IVIM within 24 h of symptom onset. The detection rate of hypoperfusion in patients with TIA was evaluated by different methods, and χ2 tests were performed. The paired t test was applied to compared cerebral blood flow (CBF), pure diffusion coefficient (D), pseudo-diffusion coefficient (D*) and perfusion fraction (f) measurements between hypoperfusion areas and contralateral normal brain regions. Pearson correlation was used to evaluate the correlations between rD*, rf and rCBF.Results: There was no significant difference in the detection rate of hypoperfusion between ASL and f (P>0.05). There was no significant difference in the positive rate between the three techniques (MRA、ASL and IVIM) and MRA combined with ASL (P=0.426). No positive result was found in D. The CBF and f in the affected sides were lower than that of contralateral areas (P<0.05), and the difference was significant (P<0 05). The D and D* between the affected sides and contralateral areas were not statistically significant (P>0.05). A significant correlation was detected between rf and rCBF. No statistically significant correlation was observed between rD* and rCBF.Conclusions: The results of IVIM f and 3D-ASL for the diagnosis of changes of brain perfusion of patients with TIA are consistent, which can be used for evaluating the real situation of cerebral perfusion. The combination of angiography and perfusion imaging is more helpful for early diagnosis of TIA, providing accurate imaging basis for clinic, and early treatment for reducing the occurrence of cerebral infarction.
[Keywords] ischemic attack, transient；magnetic resonance angiography

LI Xuan Department of Magnetic Resonance, Cardiovascular Hospital of Shanxi Province, Taiyuan 030024, China

WU Jiang* Department of Magnetic Resonance, Cardiovascular Hospital of Shanxi Province, Taiyuan 030024, China

YANG Zhaohui Department of Magnetic Resonance, Cardiovascular Hospital of Shanxi Province, Taiyuan 030024, China

ZHU Lina Department of Magnetic Resonance, Cardiovascular Hospital of Shanxi Province, Taiyuan 030024, China

NIU Heng Department of Magnetic Resonance, Cardiovascular Hospital of Shanxi Province, Taiyuan 030024, China

HAO Xiaoyong Department of Magnetic Resonance, Cardiovascular Hospital of Shanxi Province, Taiyuan 030024, China

*Correspondence to: Wu J, E-mail: wujiang1024@sina.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This article is supported by Key Research and Development Projects of Shanxi Province No. 201703D321017-4
Received  2019-12-27
Accepted  2020-04-06
DOI: 10.12015/issn.1674-8034.2020.05.001
Cite this article as: Li X, Wu J, Yang ZH, et al. The application value of MRA, 3D-ASL and IVIM technology in TIA. Chin J Magn Reson Imaging, 2020, 11(5): 321-325. DOI:10.12015/issn.1674-8034.2020.05.001.

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