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• Original Article •
Correlative study of magnetic resonance T2-mapping and DTI in sheep knee cartilage degeneration
ZHANG Xiyao  YU Jinghong 

Cite this article as: Zhang XY, Yu JH. Correlative study of magnetic resonance T2-mapping and DTI in sheep knee cartilage degeneration. Chin J Magn Reson Imaging, 2020, 11(5): 348-353. DOI:10.12015/issn.1674-8034.2020.05.006.


[Abstract] Objective: Magnetic resonance T2-mapping and diffusion tensor imaging (DTI) examination of sheep knee cartilage degeneration model, reveal the characteristics and regularity of MRI manifestations of sheep articular cartilage degeneration, parallel quantitative evaluation.Materials and Methods: Twenty-five healthy sheep were selected and randomly divided into 5 groups. Group A was the control group; groups B, C, D, and E were the building blocks. Perform conventional MRI, T2-mapping, and DTI scans of the cartilage of the knee joints of each group, measure T2 values on T2-mapping, measure ADC values and FA values on DTI, and perform T2, ADC, and FA values on each group statistical analysis.Results: The T2 value of cartilage in each group after modeling was increased compared with the control group (P<0.001) and generally increased; the ADC value of cartilage in each group after modeling was increased (P <0.001) and significantly increased compared with the control group There was a difference in the pairwise comparison among the five groups (P<0.01). The FA value of the post-condylar cartilage in each model group decreased compared with the control group (P<0.001).Conclusions: In the early stage of sheep knee cartilage, T2 and ADC values increase with the extension of the experimental period, and the ADC value is more sensitive than T2 value with the extension of the experimental period. Based on this, the T2 value and ADC value can be used to evaluate the sheep knee cartilage degree of damage. The FA value decreased during the degeneration of cartilage of sheep knee joint. No regularity of FA change was found in each experimental cycle, which needs further study.
[Keywords] articular cartilage degeneration；sheep knee joint；diffusion tensor imaging；magnetic resonance imaging

ZHANG Xiyao Department of Interventional Radiology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010030, China

YU Jinghong* Department of Imaging, the Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010030, China

*Correspondence to: Yu JH, E-mail: yujinghong200@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This paper is supported by National Natural Science Foundation of China No. 81560277
Received  2019-11-11
Accepted  2020-04-06
DOI: 10.12015/issn.1674-8034.2020.05.006
Cite this article as: Zhang XY, Yu JH. Correlative study of magnetic resonance T2-mapping and DTI in sheep knee cartilage degeneration. Chin J Magn Reson Imaging, 2020, 11(5): 348-353. DOI:10.12015/issn.1674-8034.2020.05.006.

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