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• Clinical Article •
Correlation between MMSE and amido proton transfer, susceptibility-weighted imaging in Alzheimer's disease
ZHANG Cong  ZHENG Yang  WANG Xiaoming 

Cite this article as: Zhang C, Zheng Y, Wang XM. Correlation between MMSE and amido proton transfer, susceptibility-weighted imaging in Alzheimer's disease. Chin J Magn Reson Imaging, 2020, 11(6): 406-410. DOI:10.12015/issn.1674-8034.2020.06.002.


[Abstract] Objective: To evaluate the correlation between the phase values of magnetic resonance amido proton transfer (APT) imaging, magnetic sensitivity weighted imaging (SWI) and the scores of neuropsychological scale in patients with Alzheimer's disease (AD).Materials and Methods: Twenty AD patients and 20 age and gender matched normal controls were selected for routine skull sequence, SWI and APT imaging. The asymmetric magnetization transfer ratio (MTRasym) and phase value of amide protons (at 3.5 ppm) in the region of interest were measured by selecting bilateral hippocampus, amygdala and substantia nigra on the APT image and SWI phase map of the transection position. All subjects were assessed with mini mental state examination (MMSE). The difference of MTRasym (3.5 ppm) and phase value between normal control group and AD group was compared. Pearson correlation was used to analyze the correlation between the value of MTRasym (3.5 ppm), phase value and MMSE score.Results: the MTRasym (3.5 ppm) value of bilateral hippocampus in AD group was significantly higher than that in normal control group [right side: (1.39±0.17)% and (0.88±0.29)%, t=4.444, P=0.000; left side: (1.42±0.31)% and (0.91±0.36)%, t=3.867, P=0.000]. The phase value of bilateral hippocampus and substantia nigra in AD group was lower than that in normal control group (P<0.05). The MTRasym (3.5ppm) value of bilateral hippocampus was negatively correlated with MMSE score (r=-0.618 on the right, P=0.004; r=-0.513 on the left, P=0.021), and the phase value of bilateral hippocampus (r=0.446 on the right, P=0.049; r=0.518 on the left, P=0.019 and substantia nigra (r=0.593 on the right, P=0.006; r=0.898 on the left, P=0.000) was positively correlated with MMSE score.Conclusions: APT and SWI imaging can detect the protein content and iron content in hippocampus and substantia nigra of AD patients sensitively, which is helpful for AD diagnosis.
[Keywords] Alzheimer's disease；amide proton transfer；susceptibility-weighted imaging；hippocampus；substantia nigra；amygdaloid body

ZHANG Cong Department of Radiology, Shengjing Hospital Affiliated to China Medical University, Shenyang 110004, China

ZHENG Yang Department of Radiology, Shengjing Hospital Affiliated to China Medical University, Shenyang 110004, China

WANG Xiaoming* Department of Radiology, Shengjing Hospital Affiliated to China Medical University, Shenyang 110004, China

*Correspondence to: Wang XM, E-mail: wangxm024@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foundation of China No.81471720 Basic Research Project of Key Laboratory of Educationg Department of Liaoning Province No. LZ2014039 Outstanding Scientific Fund of Shengjing Hospital No.201402
Received  2019-12-23
Accepted  2020-04-15
DOI: 10.12015/issn.1674-8034.2020.06.002
Cite this article as: Zhang C, Zheng Y, Wang XM. Correlation between MMSE and amido proton transfer, susceptibility-weighted imaging in Alzheimer's disease. Chin J Magn Reson Imaging, 2020, 11(6): 406-410. DOI:10.12015/issn.1674-8034.2020.06.002.

[1]
Dogan M, Koc G, Doganay S, et al. Evaluation of symmetrical increased echogenicity of bilateral caudothalamic grooves detected on cranial ultrasonography by comparing with susceptibility-weighted imaging. Radiol Med, 2018, 123(6): 434-440.
[2]
Zhou J, Payen J, Wilson D, et al. Using the amide proton signals of intracellular proteins and peptides to detect PH effects in MRI. Nat Med, 2003, 9(8): 1085-1090.
[3]
Cristóvão J, Santos R, Gomes C. Metals and neuronal metal binding proteins implicated in Alzheimer’s disease. Oxid Med Cell Longev, 2016, 2016: 9812178.
[4]
Zhou J, Zhu H, Lim M, et al. Three-dimensional amide proton transfer MR imaging of gliomas: Initial experience and comparison with gadolinium enhancement. J Magn Reson Imaging, 2013, 38(5): 1119-1128.
[5]
Grabner G, Kiesel B, Wöhrer A, et al. Local image variance of 7 Tesla SWI is a new technique for preoperative characterization of diffusely infiltrating gliomas: correlation with tumour grade and IDH1 mutational status. Eur Radiol, 2017, 27(4): 1556-1567.
[6]
James S, Churches Q, de Jonge M, et al. Iron, copper, and zinc concentration in Aβ plaques in the APP/PS1 mouse model of Alzheimer’s disease correlates with metal levels in the surrounding neuropil. ACS Chem Neurosci, 2017, 8(3): 629-637.
[7]
Ana M, Naftali R. Appraising the role of iron in brain aging and cognition: Promises and limitations of MRI methods. Neuropsychol Rev, 2015, 25(3): 272-287.
[8]
Arvanitakis Z, Fleischman D, Arfanakis K, et al. Association of white matter hyperintensities and gray matter volume with cognition in older individuals without cognitive impairment. Brain Struct Funct, 2016, 221(4): 2135-2146.
[9]
Koss D, Jones G, Cranston A, et al. Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer’s disease and track disease progression and cognitive decline. Acta Neuropathol, 2016, 132(6): 875-895.
[10]
Köpke E, Tung Y, Shaikh S, et al. Microtubule-associated protein tau: Abnormal phosphorylation of non-paired helical filament pool in Alzheimer disease. J Biol Chem, 1993, 268(32): 24374-24384.
[11]
Xu G, Ran Y, Fromholt S, et al. Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits. Acta Neuropathol Commun, 2015, 3(4): 72-87.
[12]
LaClair K, Donde A, Ling J, et al. Depletion of TDP-43 decreases fibril and plaque β-amyloid and exacerbates neurodegeneration in an Alzheimer’s mouse model. Acta Neuropathol, 2016, 132(6): 859-873.
[13]
Butterfield D, Swomley A, Sultana R. Amyloid β-peptide (1-42)-induced oxidative stress in Alzheimer disease: importance in disease pathogenesis and progression. Antioxid Redox Signal, 2013, 19(8): 823-835.
[14]
Jacqueline R, Edward D. Chronic traumatic encephalopathy-integration of canonical traumatic brain injury secondary injury mechanisms with tau pathology. Prog Neurobiol, 2017, 158(11): 15-44.
[15]
More S, Vince R. Hyperspectral imaging signatures detect amyloidopathy in Alzheimer’s mouse retina well before onset of cognitive decline. ACS Chem Neurosci, 2015, 6(2): 306-315.
[16]
Gao L, Jiang Z, Cai Z, et al. Brain iron deposition analysis using susceptibility weighted imaging and its association with body iron level in patients with mild cognitive impairment. Mol Med Rep, 2017, 16(6): 8209-8215.
[17]
Du L, Zhao Z, Cui A, et al. Increased iron deposition on brain quantitative susceptibility mapping correlates with decreased cognitive function in Alzheimer’s disease. ACS Chem Neurosci, 2018, 9(7): 1849-1857.
[18]
Moon Y, Han S, Moon W, et al. Patterns of brain iron accumulation in vascular dementia and Alzheimer’s dementia using quantitative susceptibility mapping imaging. J Alzheimers Dis, 2016, 51(3): 737-745.
[19]
Walker K. Inflammation and neurodegeneration: chronicity matters. Aging, 2018, 11(1): 3-4.
[20]
Wang R, Li S, Chen M. Amide proton transfer magnetic resonance imaging of Alzheimer’s disease at 3.0 Tesla: a preliminary study. Chin Med J, 2015, 128(5): 615-619.
[21]
Murakami Y, Kakeda S, Watanabe K, et al. Usefulness of quantitative susceptibility mapping for the diagnosis of Parkinson disease. AJNR Am J Neuroradiol, 2015, 36(6): 1102-1108．
[22]
Kumar A, Singh S, Singh A, et al. Diffusion tensor imaging based white matter changes and antioxidant enzymes status for early identification of mild cognitive impairment. Int J Neurosci, 2019, 129(3): 209-216.
[23]
张毅，张生林．阿尔茨海默病的磁共振成像脑线性与体积测量的研究．山西医药杂志, 2005, 34(1): 41-42.

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