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• Clinical Article •
The study of T1 and T2 values in differentiating of benign and malignant gliomas
WANG Jia’nan  ZHU Jingyi  ZHANG Bo  LI Songbai 

Cite this article as: Wang JN, Zhu JY, Zhang B, et al. The study of T1 and T2 values in differentiating of benign and malignant gliomas. Chin J Magn Reson Imaging, 2020, 11(6): 416-421. DOI:10.12015/issn.1674-8034.2020.06.004.


[Abstract] Objective: To discuss the value in the classification of cerebral gliomas using magnetic resonance image complication (Magic).Materials and Methods: Twenty-two cases with gliomas confirmed by clinical surgery pathology (13 cases of high grade, 9 cases of low grade) were included. All cases were performed with Magic technology before and after enhancement; T1 values (qT1) and T2 values (qT2) within the tumor parenchyma, and peritumoral region (within 1cm around the tumor parenchyma) were measured using automatically generated T1maping and T2 maping images. Receiver operating characteristic analysis (ROC) of T1 value after enhancement and the percentage change of T1 value were performed to evaluate cut-off values between high and low-grade tumors. The sensitivity and specificity were analyzed between high-grade glioma tumor (HGG) and low-grade gliomas (LGG) with independent sample t-test.Results: The pre-contrast T1 and T2 value of the HGG parenchyma were: 1478.59±232.92, and 127.41±20.02, and T1 value after enhancement was 688.44±143.79; The percentage change of T1 value was (127±68)%; The pre-contrast T1 and T2 value of the LGG parenchyma were 1610.78±333.87, 167.15±61.09, and T1 value after enhancement was 1189.37±592.37; The percentage change of T1 value was (58±63)%. The post-contrast qT1 of HGG parenchyma was less than that of LGG parenchyma, and the percentage change of T1 value of HGG parenchyma was greater than that of LGG parenchyma significantly (P<0.05); there were no significant differences in other measured values between the two groups. the pre-contrast T1 and T2 value of the HGG peritumoral region HGG were 1367.36±213.64 and 162.87±35.56, and T1 value after enhancement was 1334.67±260.85; the percentage change of T1 value was (4±10)%. The pre-contrast T1 and T2 value of the LGG peritumoral region were: 1239.00±259.46 and 133.07±48.07, and T1 value after enhancement was 1160.48±286.44; the percentage change of T1 value was (8±9)%. There was no statistical difference between all measured values of peritumoral regions between the HGG and LGG groups (P>0.05). The area under the ROC curve (AUC) of qT1 after enhancement was=0.786, and the diagnostic threshold was 927 ms; the sensitivity was 55.6%, and the specificity was 100%. The AUC of the rate of the percentage change of T1 value was 0.786, and the diagnostic threshold was 42.5%; the sensitivity was 92.3%, and the specificity was 55.6%.Conclusions: The Magic scan sequence may assist in the grading of cerebral gliomas.
[Keywords] magnetic resonance imaging；gliomas；brain；neoplasm grading

WANG Jia’nan The First Hospital of China Medical University, Shenyang 110001, China

ZHU Jingyi The First Hospital of China Medical University, Shenyang 110001, China

ZHANG Bo The First Hospital of China Medical University, Shenyang 110001, China

LI Songbai* The First Hospital of China Medical University, Shenyang 110001, China

*Correspondence to: Li SB, E-mail: songbaili001@163.com

Conflicts of interest   None.

Received  2020-02-22
Accepted  2020-04-15
DOI: 10.12015/issn.1674-8034.2020.06.004
Cite this article as: Wang JN, Zhu JY, Zhang B, et al. The study of T1 and T2 values in differentiating of benign and malignant gliomas. Chin J Magn Reson Imaging, 2020, 11(6): 416-421. DOI:10.12015/issn.1674-8034.2020.06.004.

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