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• Original Article •
Evaluation of skeletal muscle microvascular permeability and texture analysis based on DCE-MRI in diabetic mellitus merged with critical limb ischemia rabbits
YANG Qi  YAN Yuchen  LIU Huan  YANG Liu  PENG Lin  ZHANG Yubiao  ZHA Yunfei 

Cite this article as: Yang Q, Yan YC, Liu H, et al. Evaluation of skeletal muscle microvascular permeability and texture analysis based on DCE-MRI in diabetic mellitus merged with critical limb ischemia rabbits. Chin J Magn Reson Imaging, 2020, 11(6): 427-432. DOI:10.12015/issn.1674-8034.2020.06.006.


[Abstract] Objective: To evaluate skeletal muscle microvascular permeability and blood perfusion in diabetic rabbits with critical limb ischemia by using permeability and texture analysis based on quantitative dynamic contrast enhanced magnetic resonance imaging (DCE-MRI).Materials and Methods: Japanese big ear rabbits were randomly assigned to experimental (n=12) and sham-operated (n=12) group. After modeling, all rabbits underwent axial MR imaging (DCE-MRI) of the vastus lateralis muscle at fixed time points (1, 2, 3 weeks after operation). The pharmacokinetic model was used to acquire the quantitative permeability parameters of DCE-MRI and texture analysis based on Ktrans. Independent sample t test or Mann-Whitney U test and repeated measures analysis was used to compare the difference of permeability parameters between experimental and sham-operated group at the same time point. The texture features extracted in both group at week 3 were modeled for further feature screening. The area under the curve (AUC) was obtained by joint ROC curve analysis of the texture parameters with statistical differences. The correlation of permeability parameters and texture parameters with MVD (CD31) and peripheral blood EPCs was analyzed.Results: The difference of vastus lateralis muscle of Ktrans value at each time point in the experimental group was statistically significant, Texture analysis based on DCE-MRI were significantly different in both group. The AUC value is 0.882, there was a correlation between pathological and texture parameters.Conclusions: Permeability parameters and texture analysis based on DCE-MRI quantitative can be used to evaluate microvascular permeability and blood perfusion of diabetic mellitus merged with critical limb ischemia rabbits skeletal muscle.
[Keywords] diabetic mellitus；limb ischemia；skeletal muscle；permeability parameters；texture analysis；magnetic resonance imaging；animal experiments

YANG Qi Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

YAN Yuchen Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

LIU Huan Advanced Application Team, GE Healthcare, Shanghai 201203, China

YANG Liu Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

PENG Lin Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

ZHANG Yubiao Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan 430060, China

ZHA Yunfei* Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

*Correspondence to: Zha YF, E-mail: zhayunfei999@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foundation of China No.81871332
Received  2020-02-12
Accepted  2020-04-12
DOI: 10.12015/issn.1674-8034.2020.06.006
Cite this article as: Yang Q, Yan YC, Liu H, et al. Evaluation of skeletal muscle microvascular permeability and texture analysis based on DCE-MRI in diabetic mellitus merged with critical limb ischemia rabbits. Chin J Magn Reson Imaging, 2020, 11(6): 427-432. DOI:10.12015/issn.1674-8034.2020.06.006.

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