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The progress of functional magnetic resonance imaging and Ki-67 labeling index in the assessment of malignancy in gliomas
XIE Jiapei  XIAO Liang 

Cite this article as: Xie JP, Xiao L. The progress of functional magnetic resonance imaging and Ki-67 labeling index in the assessment of malignancy in gliomas. Chin J Magn Reson Imaging, 2020, 11(6): 462-465. DOI:10.12015/issn.1674-8034.2020.06.016.


[Abstract] Brain gliomas are the most common intracranial malignant tumor, the higher the degree of malignancy, the higher the grade, the worse the prognosis. The assessment of brain gliomas malignancy is important to predict tumor grade, tumor behavior and prognosis. Ki- 67 is a protein reflecting cellular proliferation and malignancy; higher Ki-67 labeling index correspond to higher proliferation and greater malignancy. However, the assessment of Ki- 67 labeling index requires biopsy or surgical removal, a noninvasive method to predict Ki-67 labeling index would be of great importance for the assessment of proliferative potential and malignancy of brain glioma. Using noninvasive magnetic resonance imaging techniques to predict the Ki-67 labeling index is indispensable for the assessment of tumor malignancy. In the paper, we review the contribution of functional magnetic resonance and Ki-67 labeling index for the assessment of the gliomas malignancy.
[Keywords] brain glioma；neoplasm grading；Ki-67 labeling index；functional magnetic resonance imaging；malignancy

XIE Jiapei The Fourth Affiliated Hospital of China Medical University, Shenyang 110000, China

XIAO Liang* The Fourth Affiliated Hospital of China Medical University, Shenyang 110000, China

*Corresponding to: Xiao L, E-mail: xiaoliang_cmu@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foundation of China No. 81471763
Received  2020-02-28
Accepted  2020-04-12
DOI: 10.12015/issn.1674-8034.2020.06.016
Cite this article as: Xie JP, Xiao L. The progress of functional magnetic resonance imaging and Ki-67 labeling index in the assessment of malignancy in gliomas. Chin J Magn Reson Imaging, 2020, 11(6): 462-465. DOI:10.12015/issn.1674-8034.2020.06.016.

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