Share：
Share this content in WeChat
X
[Chinese][PDF]102888
• Review •
The research progress of amide proton transfer weighted imaging in neurodegenerative disease
HU Xiao  WANG Xu  TIAN Lin  TIAN Weiwei  KONG Ran  WANG Bin 

Cite this article as: Hu X, Wang X, Tian L, et al. The research progress of amide proton transfer weighted imaging in neurodegenerative disease. Chin J Magn Reson Imaging, 2020, 11(6): 466-468. DOI:10.12015/issn.1674-8034.2020.06.017.


[Abstract] Neurodegenerative disease is a kind of disease with progressive neuronal degeneration and death, which leads to chronic progressive neurological dysfunction, including Alzheimer's disease, Parkinson's disease, multiple sclerosis and traumatic brain injury. In recent years, the incidence of neurodegenerative diseases has increased year by year, which has a serious impact on patients' daily work, study and life. Amide proton transfer imaging is a relatively new magnetic resonance imaging technique developed in recent years, which indirectly reflects the metabolic changes and physiological and pathological information in living cells by detecting endogenous free proteins and polypeptide molecules. The purpose of this paper is to explain the technical principle of APT and summarize its research status in neurodegenerative related diseases.
[Keywords] neurodegenerative disease；amide proton transfer；Alzheimer’s disease；Parkinson’s disease；multiple sclerosis；traumatic brain injury

HU Xiao Department of Radiology, Binzhou Medical University Hospital, Binzhou 256600, China

WANG Xu Department of Radiology, Binzhou Medical University Hospital, Binzhou 256600, China

TIAN Lin Department of Radiology, Binzhou Medical University Hospital, Binzhou 256600, China

TIAN Weiwei Department of Radiology, Binzhou Medical University Hospital, Binzhou 256600, China

KONG Ran Department of Radiology, Binzhou Medical University Hospital, Binzhou 256600, China

WANG Bin* Binzhou Medical University, Yantai 264003, China

*Corresponding to: Wang B, E-mail: binwang001@aliyun.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foundation of China No. 81771828 Natural Science Foundation Project of Shandong Province No. ZR2017MH037 Science and Technology Department of Universities in Shandong Province No.J18KB116
Received  2020-01-31
Accepted  2020-04-12
DOI: 10.12015/issn.1674-8034.2020.06.017
Cite this article as: Hu X, Wang X, Tian L, et al. The research progress of amide proton transfer weighted imaging in neurodegenerative disease. Chin J Magn Reson Imaging, 2020, 11(6): 466-468. DOI:10.12015/issn.1674-8034.2020.06.017.

[1]
By S, Barry RL, Smith AK, et al. Amide proton transfer CEST of the cervical spinal cord in multiple sclerosis patients at 3.0 T. Magn Reson Med, 2018, 79: 806-814.
[2]
张思雨，孙洪赞.酰胺质子转移加权成像在肿瘤中的应用进展．磁共振成像, 2019, 10(8): 629-632.
[3]
陶泉，易佩伟，魏国境，等．基于CEST机制的pH成像方法、原理和应用．波谱学杂志, 2018, 35(4): 505-519.
[4]
Kogan F, Hariharan H, Reddy R, et al. Chemical exchange saturation transfer(CEST) imaging: Description of technique and potential clinical applications. Curr Radiol Rep, 2013, 1(2): 102-114.
[5]
Zhou J, Payen JF, Wilson DA, et al. Using the amide proton signals of intracellular proteins and peptides to detect pH effects in MRI. Nat Med, 2003, 9(8): 1085-1090.
[6]
林月，李春媚，陈敏.酰胺质子转移成像的应用进展．放射学实践, 2018, 33(5): 525-528.
[7]
宋杨美惠，兰晓莉，张永学. PET/MR成像在神经退行性疾病中的应用进展．中华核医学与分子影像杂志, 2019, 39(7): 431-434.
[8]
Nasrallah IM, Wolk DA. Multimodality imaging of Alzheimer disease and other neurodegenerative dementias. J Nucl Med, 2014, 55(12): 2003-2011.
[9]
Kenkhuis B, Jonkman LE, Bulk M, et al. 7.0 T MRI allows detection of disturbed cortical lamination of the medial temporal lobe in patients with Alzheimer’s disease. NeuroImage Clin, 2019, 21: 101665.
[10]
陈甜，吴非．阿尔兹海默病和轻度认知障碍的脑结构差异：一种自动量化脑容量测量工具的使用．影像诊断与介入放射学, 2019, 28(2): 96-102.
[11]
Wang R, Li SY, Chen M, et al. Amide proton transfer magnetic resonance imaging of Alzheimer’s disease at 3.0 Tesla: A preliminary study. Chin Med J, 2015, 128(5): 615-619.
[12]
Dauer W, Przedborski S. Parkinson’s disease: Mechanisms and models. Neuron, 2003, 39(6): 889-909.
[13]
Li CM, Chen M, Zhao XN, et al. Chemical exchange saturation transfer MRI signal loss of the substantia nigra as an imaging biomarker to evaluate the diagnosis and serverity of Parkinson's disease. Front Neurosci, 2017, 11: 489.
[14]
Tiwari AD, Wu C, Zhu J, et al. Design, synthesis, and evaluation of fluorinated radioligands for myelin imaging. J Med Chem, 2016, 59(8): 3705-3718.
[15]
Reich DS, Lucchinetti CF, Calabresi PA, et al. Multiple sclerosis. N Engl J Med, 2018, 378(2): 169-180.
[16]
Brownlee WJ, Hardy TA, Fazekas F, et al. Diagnosis of multiple sclerosis: progress and challenges. Lancet, 2017, 389: 1336-1346.
[17]
Dula AN, Asche EM, Landman BA, et al. Development of chemicalexchange saturation transfer at 7.0 T. Magn Reson Med, 2011, 66(3): 831-838.
[18]
Zhang H, Wang W, Jiang S, et al. Amide proton transfer-weighted MRI detection of traumatic brain injury in rats. J Cereb Blood Flow Metab, 2017, 37(10): 3422-3432.
[19]
Wang W, Zhang H, Lee DH, et al. Using functional and molecular MRI techniques to detect neuroinflammation and neuroprotection after traumatic brain injury. Brain Behav Immun, 2017, 64: 344-353.
[20]
刘娜，尹建忠.酰胺质子转移成像在中枢神经系统中的研究进展．国际医学放射学杂志, 2018, 41(2): 151-154.
[21]
Zhou J, Heo HY, Knutsson L, et al. APT-weighted MRI: Techniques, current neuro applications, and challenging issues. J Magn Reson Imaging, 2019, 50(2): 347-364.
[22]
Togao O, Keupp J, Hiwatashi A, et al. Amide proton transfer imagingof brain tumors using a self-corrected 3D fast spin-echo dixonmethod: comparison with separate B0 correction. Magn Reson Med, 2017, 77(6): 2272-2279.
[23]
Zimmermann F, Korzowski A, Breitling J, et al. A novel normalization for amide proton transfer CEST MRI to correct for fat signal-induced artifacts: application to human breast cancer imaging. Magn Reson Med, 2020, 83(3): 920-934.
[24]
Yu L, Li C, Luo X, et al. Differentiation of malignant and benign head and neck tumors with amide proton transfer-weighted mr imaging. Mol Imaging Biol, 2019, 21(2): 348-355.
[25]
Takayama Y, Nishie A, Togao O, et al. Amide proton transfer MR imaging of endometrioid endometrial adenocarcinoma: Association with histologic grade. Radiology, 2018, 286(3): 909-917.

PREV The progress of functional magnetic resonance imaging and Ki-67 labeling index in the assessment of malignancy in gliomas
NEXT Cardiac magnetic resonance feature tracking technique and its progress
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn