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The research progress of amide proton transfer weighted imaging in neurodegenerative disease
HU Xiao  WANG Xu  TIAN Lin  TIAN Weiwei  KONG Ran  WANG Bin 

Cite this article as: Hu X, Wang X, Tian L, et al. The research progress of amide proton transfer weighted imaging in neurodegenerative disease. Chin J Magn Reson Imaging, 2020, 11(6): 466-468. DOI:10.12015/issn.1674-8034.2020.06.017.


[Abstract] Neurodegenerative disease is a kind of disease with progressive neuronal degeneration and death, which leads to chronic progressive neurological dysfunction, including Alzheimer's disease, Parkinson's disease, multiple sclerosis and traumatic brain injury. In recent years, the incidence of neurodegenerative diseases has increased year by year, which has a serious impact on patients' daily work, study and life. Amide proton transfer imaging is a relatively new magnetic resonance imaging technique developed in recent years, which indirectly reflects the metabolic changes and physiological and pathological information in living cells by detecting endogenous free proteins and polypeptide molecules. The purpose of this paper is to explain the technical principle of APT and summarize its research status in neurodegenerative related diseases.
[Keywords] neurodegenerative disease；amide proton transfer；Alzheimer’s disease；Parkinson’s disease；multiple sclerosis；traumatic brain injury

HU Xiao Department of Radiology, Binzhou Medical University Hospital, Binzhou 256600, China

WANG Xu Department of Radiology, Binzhou Medical University Hospital, Binzhou 256600, China

TIAN Lin Department of Radiology, Binzhou Medical University Hospital, Binzhou 256600, China

TIAN Weiwei Department of Radiology, Binzhou Medical University Hospital, Binzhou 256600, China

KONG Ran Department of Radiology, Binzhou Medical University Hospital, Binzhou 256600, China

WANG Bin* Binzhou Medical University, Yantai 264003, China

*Corresponding to: Wang B, E-mail: binwang001@aliyun.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foundation of China No. 81771828 Natural Science Foundation Project of Shandong Province No. ZR2017MH037 Science and Technology Department of Universities in Shandong Province No.J18KB116
Received  2020-01-31
Accepted  2020-04-12
DOI: 10.12015/issn.1674-8034.2020.06.017
Cite this article as: Hu X, Wang X, Tian L, et al. The research progress of amide proton transfer weighted imaging in neurodegenerative disease. Chin J Magn Reson Imaging, 2020, 11(6): 466-468. DOI:10.12015/issn.1674-8034.2020.06.017.

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