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Research progress in the diagnosis and treatment of tumors by magnetic iron oxide nanoparticles with chemotherapeutics
MA Mingzhong  GAO Bo  HE Jianwei  ZHAO Xuemei  ZHOU Xing 

Cite this article as: Ma MZ, Gao B, He JW, et al. Research progress in the diagnosis and treatment of tumors by magnetic iron oxide nanoparticles with chemotherapeutics. Chin J Magn Reson Imaging, 2020, 11(6): 474-476. DOI:10.12015/issn.1674-8034.2020.06.019.


[Abstract] Magnetic oxygen nanoparticles (NPs) have attracted wide attention due to their unique properties. NPs can be combined with fluorescent probes, biological targeting molecules or anti-tumor drugs to achieve the multifunctionality of magnetic nanoparticles, so they have good application prospects in multimodal imaging, targeted diagnosis and treatment of cancer. Magnetic iron oxide nanoparticles (IONP) have the advantages of small particle size, high biological safety, and superparamagnetism. In addition to T2 weight imaging (T2WI) MR imaging, IONP also has drug loading and magnetic targeting functions. It is currently a hot research topic in cancer diagnosis and treatment. This article reviews the research on IONP imaging performance, tumor targeting, and the emphasis on carrying different types of chemotherapy drugs.
[Keywords] iron oxide nanoparticles；chemotherapy drugs；magnetic resonance imaging；tumor

MA Mingzhong Department of Radiology, Gansu Provincial Hospital, Lanzhou 730000, China

GAO Bo Department of Radiology, Gansu Provincial Hospital, Lanzhou 730000, China

HE Jianwei Department of Radiology, Gansu Provincial Hospital, Lanzhou 730000, China

ZHAO Xuemei Department of Radiology, Gansu Provincial Hospital, Lanzhou 730000, China

ZHOU Xing* Department of Radiology, Gansu Provincial Hospital, Lanzhou 730000, China

*Corresponding to: Zhou X, E-mail: 317690434@qq.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foundation of Gansu No. 18JR3RA048 Gansu Provincial Hospital Foundation No. 17GSSY2-7
Received  2020-01-02
Accepted  2020-04-21
DOI: 10.12015/issn.1674-8034.2020.06.019
Cite this article as: Ma MZ, Gao B, He JW, et al. Research progress in the diagnosis and treatment of tumors by magnetic iron oxide nanoparticles with chemotherapeutics. Chin J Magn Reson Imaging, 2020, 11(6): 474-476. DOI:10.12015/issn.1674-8034.2020.06.019.

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