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• MRI of Uterine Diseases •
Prediction of microsatellite instability in endometrial carcinoma by multiple quantitative parameters of magnetic sensitive sequence
TIAN Shifeng  LIU Ailian  CHEN Lihua  LIU Jinghong  HUANG Kan 

Cite this article as: Tian SF, Liu AL, Chen LH, et al. Prediction of microsatellite instability in endometrial carcinoma by multiple quantitative parameters of magnetic sensitive sequence. Chin J Magn Reson Imaging, 2020, 11(7): 493-496. DOI:10.12015/issn.1674-8034.2020.07.003.


[Abstract] Objective: To explore the value of the quantitative parameters of enhanced T2 star weighted angiography (ESWAN) sequence in predicting microsatellite instability (MSI) of endometrial carcinoma (EC).Materials and Methods: The data of 35 patients with EC were analyzed retrospectively, included 13 cases of MSI and 22 cases of microsatellite stability (MSS). All patients were examined with 1.5 T MR before operation, the scanning sequence included ESWAN. The amplitude, phase, R2* and T2* images were created by post processing. The amplitude value, phase value, R2* value and T2* value were measured by two observers. The intra-class correlation coefficients (ICC) was used to test the consistency of the measurement results of the two observers, the independent sample t test or Mann Whitney U test was used to compare the differences between the two groups of cases, the receiver operator characteristic (ROC) curve was used to evaluate the effectiveness of each parameter in predicting MSI.Results: The data measured by the two observers had good consistency (ICC value> 0.75). The R2* value of MSI group (15.303±2.274) Hz was significantly higher than that of MSS group (13.051±1.595) Hz, while the T2* value of MSI group (71.883±8.323) ms was significantly lower than that of MSS group (84.246±12.553) ms (P< 0.05). No statistical differences were observed in the amplitude and phase values between two groups (P>0.05). The AUC, sensitivity, specificity of EC MSI predicted by R2* value and T2* value were 0.797, 84.6%, 63.6% and 0.787, 84.6%, 68.2%, respectively.Conclusions: The R2* value and T2* value of ESWAN can forecast the MSI state of EC, which has certain clinical application value.
[Keywords] endometrial neoplasms；magnetic resonance imaging；microsatellite instability；prediction

TIAN Shifeng Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

LIU Ailian* Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

CHEN Lihua Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

LIU Jinghong Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

HUANG Kan Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

*Correspondence to: Liu AL, E-mail: liuailian@dmu.edu.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS  Program for Training Capital Science and Technology Leading Talents No. Z181100006318003
Received  2020-01-30
Accepted  2020-05-21
DOI: 10.12015/issn.1674-8034.2020.07.003
Cite this article as: Tian SF, Liu AL, Chen LH, et al. Prediction of microsatellite instability in endometrial carcinoma by multiple quantitative parameters of magnetic sensitive sequence. Chin J Magn Reson Imaging, 2020, 11(7): 493-496. DOI:10.12015/issn.1674-8034.2020.07.003.

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