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• MRI of Uterine Diseases •
Prediction of microsatellite instability in endometrial carcinoma by multiple quantitative parameters of magnetic sensitive sequence
TIAN Shifeng  LIU Ailian  CHEN Lihua  LIU Jinghong  HUANG Kan 

Cite this article as: Tian SF, Liu AL, Chen LH, et al. Prediction of microsatellite instability in endometrial carcinoma by multiple quantitative parameters of magnetic sensitive sequence. Chin J Magn Reson Imaging, 2020, 11(7): 493-496. DOI:10.12015/issn.1674-8034.2020.07.003.


[Abstract] Objective: To explore the value of the quantitative parameters of enhanced T2 star weighted angiography (ESWAN) sequence in predicting microsatellite instability (MSI) of endometrial carcinoma (EC).Materials and Methods: The data of 35 patients with EC were analyzed retrospectively, included 13 cases of MSI and 22 cases of microsatellite stability (MSS). All patients were examined with 1.5 T MR before operation, the scanning sequence included ESWAN. The amplitude, phase, R2* and T2* images were created by post processing. The amplitude value, phase value, R2* value and T2* value were measured by two observers. The intra-class correlation coefficients (ICC) was used to test the consistency of the measurement results of the two observers, the independent sample t test or Mann Whitney U test was used to compare the differences between the two groups of cases, the receiver operator characteristic (ROC) curve was used to evaluate the effectiveness of each parameter in predicting MSI.Results: The data measured by the two observers had good consistency (ICC value> 0.75). The R2* value of MSI group (15.303±2.274) Hz was significantly higher than that of MSS group (13.051±1.595) Hz, while the T2* value of MSI group (71.883±8.323) ms was significantly lower than that of MSS group (84.246±12.553) ms (P< 0.05). No statistical differences were observed in the amplitude and phase values between two groups (P>0.05). The AUC, sensitivity, specificity of EC MSI predicted by R2* value and T2* value were 0.797, 84.6%, 63.6% and 0.787, 84.6%, 68.2%, respectively.Conclusions: The R2* value and T2* value of ESWAN can forecast the MSI state of EC, which has certain clinical application value.
[Keywords] endometrial neoplasms；magnetic resonance imaging；microsatellite instability；prediction

TIAN Shifeng Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

LIU Ailian* Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

CHEN Lihua Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

LIU Jinghong Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

HUANG Kan Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

*Correspondence to: Liu AL, E-mail: liuailian@dmu.edu.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS  Program for Training Capital Science and Technology Leading Talents No. Z181100006318003
Received  2020-01-30
Accepted  2020-05-21
DOI: 10.12015/issn.1674-8034.2020.07.003
Cite this article as: Tian SF, Liu AL, Chen LH, et al. Prediction of microsatellite instability in endometrial carcinoma by multiple quantitative parameters of magnetic sensitive sequence. Chin J Magn Reson Imaging, 2020, 11(7): 493-496. DOI:10.12015/issn.1674-8034.2020.07.003.

[1]
Goodfellow PJ, Buttin BM, Herzog TJ, et al. Prevalence of defective DNA mismatch repair and MSH6 mutation in an unselected series of endometrial cancers. Proc Natl Acad, 2003, 100(10): 5908-5913.
[2]
Wadee R, Grayson W. A potpourri of pathogenetic pathways in endometrial carcinoma with a focus on lynch syndrome. Ann Diagn Pathol, 2019, 39: 92-104.
[3]
Luchini C, Bibeau F, Ligtenberg MJ, et al. ESMO recommendations on microsatellite instability testing for immunotherapy in cancer, and its relationship with PD-1/PD-L1 expression and tumour mutational burden: a systematic review-based approach. Ann Oncol, 2019, 30(8): 1232-1243.
[4]
Li Z, Cao L, Dong W, et al. Prevalence and Risk Factors of Cerebral Microbleeds in Patients with Nonvalvular Atrial Fibrillation: An Enhanced T2*-Weighted Angiography Imaging Study. Eur Neurol, 2019, 81(3-4): 112-119.
[5]
Kane AM, Fennell LJ, Liu C, et al. Alterations in signaling pathways that accompany spontaneous transition to malignancy in a mouse model of BRAF mutant microsatellite stable colorectal cancer. Neoplasia, 2020, 22(2): 120-128.
[6]
Greenberg A, Kariv R, Solar I, et al. Geographic heterogeneity for mismatch repair proteins is associated with defects in DNA repair. Isr Med Assoc J, 2020, 22(1): 32-36.
[7]
Wu X, Snir O, Rottmann D, et al. Minimal microsatellite shift in microsatellite instability high endometrial cancer: a significant pitfall in diagnostic interpretation. Mod Pathol, 2019, 32(5): 650-658.
[8]
Bhosale P, Ramalingam P, Ma J, et al. Can reduced field-of-view diffusion sequence help assess microsatellite instability in FIGO stage 1 endometrial cancer? J Magn Reson Imaging, 2017, 45(4): 1216-1224.
[9]
Ahmed M, Al-Khafaji JF, Class CA, et al. Can MRI help assess aggressiveness of endometrial cancer? Clin Radiol, 2018, 73(9): 833. e11-833.e18.
[10]
Chen XQ, Niu JP, Peng RQ, et al. The early diagnosis of Parkinson’s disease through combined biomarkers. Acta Neurol Scand, 2019, 140(4): 268-273.
[11]
Vanaerde O, Budzik JF, Mackowiak A, et al. Comparison between enhanced susceptibility-weighted angiography and time of flight sequences in the detection of arterial occlusion in acute ischemic stroke. J Neuroradiol, 2017, 44(3): 210-216.
[12]
Zeng C, Du S, Han Y, et al. Optic radiations are thinner and show signs of iron deposition in patients with long-standing remitting-relapsing multiple sclerosis: an enhanced T2*-weighted angiography imaging study. Eur Radiol, 2018, 28(10): 4447-4454.
[13]
Xin JY, Gao SS, Liu JG, et al. The value of ESWAN in diagnosis and differential diagnosis of prostate cancer: Preliminary study. Magn Reson Imaging, 2017, 44: 26-31.
[14]
Han X, Sun M, Wang M, et al. The enhanced T2 star weighted angiography (ESWAN) value for differentiating borderline from malignant epithelial ovarian tumors. Eur J Radiol, 2019, 118: 187-193.
[15]
Li Y, Song QW, Sun MY, et al. Use of enhanced T2 star-weighted angiography (ESWAN) and R2* values to distinguish ovarian cysts due to endometriosis from other causes. Abdom Imaging, 2015, 40(6): 1733-1741.
[16]
van den Bos M, van den Hoven M, Jongejan E, et al. More differences between HNPCC-related and sporadic carcinomas from the endometrium as compared to the colon. Am J Surg Pathol, 2004, 28(6): 706-711.
[17]
Howitt BE, Shukla SA, Sholl LM, et al. Association of polymerase e-mutated and microsatellite-instable endometrial cancers with neoantigen load, number of tumor-infiltrating lymphocytes, and expression of PD-1 and PD-L1. JAMA Oncol, 2015, 1(9): 1319-1323.

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