Share：
Share this content in WeChat
X
[Chinese][PDF]92591
• Clinical Article •
Routine MRI study of craniopharyngioma with brain invasion
ZHANG Lingling  ZHANG Yu  CHEN Hongyan  SHEN Huicong  CHEN Xuzhu 

Cite this article as: Zhang LL, Zhang Y, Chen HY, et al. Routine MRI study of craniopharyngioma with brain invasion. Chin J Magn Reson Imaging, 2020, 11(7): 522-525. DOI:10.12015/issn.1674-8034.2020.07.009.


[Abstract] Objective: To explore the routine MRI characteristics of craniopharyngioma (CP) with brain invasion.Materials and Methods: The retrospective study recruited 138 patients with CP which was proven by post-operative pathology. The preoperative MRI was analyzed, focused on obstructive hydrocephalus and tumor size. These radiological indices and the pathological ratio of adamantinomatous type were compared between the adult (64 cases) and the juvenile patients (74 cases). The radiological and pathological indices, patient age and sex were also compared between tumors with and those without brain invasion. Finally, according to brain invasion which was pathologically diagnosed, both the adult and juvenile patients were divided into two sub-groups with the indices compared.Results: (1) Grouped by age: ① The tumor volume in the adult and juvenile group was 8619.5 (5358.0—12568.8) mm3 and 11469.0 (5367.4—26560.1) mm3, respectively. The difference was significant (P=0.008). ② The ratio of adamantinomatous CP was 56.3% (36/64) in the adult group, significantly lower than that of the juvenile group [83.8% (62/74); χ2=12.640, P<0.01]. (2) Grouped by invasion: ① The ratio of hydrocephalus was 46% (22/48) in the invasive group and 18% (16/90) in the non-invasive group, significantly different (χ2=12.349, P<0.01). ② The ratio of adamantinomatous CP was 90% (43/48) in the invasive group and 61% (55/90) in the non-invasive group, with a significant difference (χ2=12.329, P<0.01). (3) In the adult group, the ratio of adamantinomatous type was 78% (18/23) and 44% (18/41) in the invasive and non-invasive sub-group, respectively, showing a significant difference (χ2=7.068, P=0.008). (4) In the juvenile group: ① The ratio of adamantinomatous tumor was 100% (25/25) and 76% (37/49) in the invasive and non-invasive sub-group, respectively, significantly different (χ2=5.616, P=0.018). ② The ratio of hydrocephalus was 60% (15/25) in the invasive sub-group and 20% (10/49) in the non-invasive sub-group. The difference was significant (χ2=11.600, P=0.001).Conclusions: The tumor volume and pathological types are different in CP patient with different age. CP with brain invasion shows a preference of adamantinomatous type, obstructive hydrocephalus, and younger age.
[Keywords] craniopharyngioma；hydrocephalus；magnetic resonance imaging

ZHANG Lingling Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China

ZHANG Yu Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China

CHEN Hongyan Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China

SHEN Huicong Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China

CHEN Xuzhu* Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China

*Correspondence to: Chen, XZ, E-mail: radiology888@aliyun.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Key Research and Development Program of China No. 2018YFC0115604 National Natural Science Foundation No. 81772005 Collaborative innovative major special project supported by Beijing Municipal Science & Technology Commission No. Z191199996619088 High Level Health Technical Personnel Training Funding of Beijing Municipal Health Department of China No. 2015-3-042
Received  2020-02-24
Accepted  2020-04-10
DOI: 10.12015/issn.1674-8034.2020.07.009
Cite this article as: Zhang LL, Zhang Y, Chen HY, et al. Routine MRI study of craniopharyngioma with brain invasion. Chin J Magn Reson Imaging, 2020, 11(7): 522-525. DOI:10.12015/issn.1674-8034.2020.07.009.

[1]
Louis DN, Perry A, Reifenberger G, et al. The 2016 world health organization classification of tumors of the central nervous system: a summary. Acta Neuropathol, 2016, 131(6): 803-820.
[2]
Prieto R, Pascual JM, Rosdolsky M, et al. Craniopharyngioma adherence: a comprehensive topographical categorization and outcome-related risk stratification model based on the methodical examination of 500 tumors. Neurosurg Focus, 2016, 41(6): E13.
[3]
Prieto R, Pascual JM, Barrios L. Harvey Cushing's craniopharyngioma treatment: Part 2. Surgical strategies and results of his pioneering series. Neurosurg, 2018, 131(3): 964-978.
[4]
Desiderio C, Martelli C, Rossetti DV, et al. Identification of thymosins β 4 and β 10 in paediatric craniopharyngioma cystic fluid. Childs Nerv Syst, 2013, 29(6): 951-960.
[5]
Gil-Simoes R, Pascual JM, Casas AP, et al. Intrachiasmatic craniopharyngioma: Assessment of visual outcome with optical coherence tomography after complete surgical removal. Surg Neurol Int, 2019, 10(1): 7.
[6]
Pickering L, Klose M, Feldt-Rasmussen U, et al. Polysomnographic findings in craniopharyngioma patients. Sleep Breath, 2017, 21(4): 975-982.
[7]
Apps JR, Hutchinson JC, Arthurs OJ, et al. Imaging invasion: micro-CT imaging of adamantinomatous craniopharyngioma highlights cell type specific spatial relationships of tissue invasion. Acta Neuropathol Commun, 2016, 4(1): 57.
[8]
Puget S, Garnett M, Wray A, et al. Pediatric craniopharyngiomas: classification and treatment according to the degree of hypothalamic involvement. Neurosurg, 2007, 106(1Suppl): 3-12.
[9]
Mortini P, Gagliardi F, Bailo M, et al. Magnetic resonance imaging as predictor of functional outcome in craniopharyngiomas. Endocrine, 2016, 51(1): 148-162.
[10]
Sreenivasan SA, Madhugiri VS, Sasidharan GM, et al. Measuring glioma volumes: a comparison of linear measurement based formulae with the manual image segmentation technique. Cancer Res Ther, 2016, 12(1): 161-168.
[11]
Müller HL, Merchant TE, Warmuth-Metz M, et al. Craniopharyngioma. Nat Rev Dis Primers, 2019, 5(1): 75.
[12]
Bogusz A, Müller HL. Childhood-onset craniopharyngioma: latest insights into pathology, diagnostics, treatment, and follow-up. Expert Rev Neurother, 2018, 18(10): 793-806.
[13]
Crotty TB, Scheithauer BW, Young WF Jr, et al. Papillary craniopharyngioma: a clinicopathological study of 48 cases. Neurosurg, 1995, 83(2): 206-214.
[14]
Zhu J, You C. Craniopharyngioma: survivin expression and ultrastructure. Oncol Lett, 2015, 9(1): 75-80.
[15]
Nie J, Huang GL, Deng SZ, et al. The purine receptor P2X7R regulates the release of pro-inflammatory cytokines in human craniopharyngioma. Endocr Relat Cancer, 2017, 24(6): 287-296.
[16]
Hankinson TC, Kleinschmidt-DeMasters BK. Adamantinomatous craniopharyngioma and xanthomatous lesions of the sella. Brain Pathol, 2017, 27(3): 356-357.
[17]
Chen C, Wang Y, Zhong K, et al. Frequent B7-H3 overexpression in craniopharyngioma. Biochem Biophys Res Commun, 2019, 514(2): 379-385.

PREV Study on the application of DTI technology in the subtle structural changes of the brain in hypertensive patients with and without obstructive sleep apnea
NEXT A comparative study of 3.0 tesla cardiac magnetic resonance imaging on cardiac structure and function of healthy normal people in plateau and plain areas
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn