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• Clinical Article •
Routine MRI study of craniopharyngioma with brain invasion
ZHANG Lingling  ZHANG Yu  CHEN Hongyan  SHEN Huicong  CHEN Xuzhu 

Cite this article as: Zhang LL, Zhang Y, Chen HY, et al. Routine MRI study of craniopharyngioma with brain invasion. Chin J Magn Reson Imaging, 2020, 11(7): 522-525. DOI:10.12015/issn.1674-8034.2020.07.009.


[Abstract] Objective: To explore the routine MRI characteristics of craniopharyngioma (CP) with brain invasion.Materials and Methods: The retrospective study recruited 138 patients with CP which was proven by post-operative pathology. The preoperative MRI was analyzed, focused on obstructive hydrocephalus and tumor size. These radiological indices and the pathological ratio of adamantinomatous type were compared between the adult (64 cases) and the juvenile patients (74 cases). The radiological and pathological indices, patient age and sex were also compared between tumors with and those without brain invasion. Finally, according to brain invasion which was pathologically diagnosed, both the adult and juvenile patients were divided into two sub-groups with the indices compared.Results: (1) Grouped by age: ① The tumor volume in the adult and juvenile group was 8619.5 (5358.0—12568.8) mm3 and 11469.0 (5367.4—26560.1) mm3, respectively. The difference was significant (P=0.008). ② The ratio of adamantinomatous CP was 56.3% (36/64) in the adult group, significantly lower than that of the juvenile group [83.8% (62/74); χ2=12.640, P<0.01]. (2) Grouped by invasion: ① The ratio of hydrocephalus was 46% (22/48) in the invasive group and 18% (16/90) in the non-invasive group, significantly different (χ2=12.349, P<0.01). ② The ratio of adamantinomatous CP was 90% (43/48) in the invasive group and 61% (55/90) in the non-invasive group, with a significant difference (χ2=12.329, P<0.01). (3) In the adult group, the ratio of adamantinomatous type was 78% (18/23) and 44% (18/41) in the invasive and non-invasive sub-group, respectively, showing a significant difference (χ2=7.068, P=0.008). (4) In the juvenile group: ① The ratio of adamantinomatous tumor was 100% (25/25) and 76% (37/49) in the invasive and non-invasive sub-group, respectively, significantly different (χ2=5.616, P=0.018). ② The ratio of hydrocephalus was 60% (15/25) in the invasive sub-group and 20% (10/49) in the non-invasive sub-group. The difference was significant (χ2=11.600, P=0.001).Conclusions: The tumor volume and pathological types are different in CP patient with different age. CP with brain invasion shows a preference of adamantinomatous type, obstructive hydrocephalus, and younger age.
[Keywords] craniopharyngioma；hydrocephalus；magnetic resonance imaging

ZHANG Lingling Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China

ZHANG Yu Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China

CHEN Hongyan Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China

SHEN Huicong Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China

CHEN Xuzhu* Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China

*Correspondence to: Chen, XZ, E-mail: radiology888@aliyun.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Key Research and Development Program of China No. 2018YFC0115604 National Natural Science Foundation No. 81772005 Collaborative innovative major special project supported by Beijing Municipal Science & Technology Commission No. Z191199996619088 High Level Health Technical Personnel Training Funding of Beijing Municipal Health Department of China No. 2015-3-042
Received  2020-02-24
Accepted  2020-04-10
DOI: 10.12015/issn.1674-8034.2020.07.009
Cite this article as: Zhang LL, Zhang Y, Chen HY, et al. Routine MRI study of craniopharyngioma with brain invasion. Chin J Magn Reson Imaging, 2020, 11(7): 522-525. DOI:10.12015/issn.1674-8034.2020.07.009.

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