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• Clinical Article •
Comparison between IVIM parameters and ADC value in rectal cancer for estimate histological grade
WENG Xiaoyan  JIANG Heng  JI Libiao  LU Zhihua 

Cite this article as: Weng XY, Jiang H, Ji LB, et al. Comparison between IVIM parameters and ADC value in rectal cancer for estimate histological grade. Chin J Magn Reson Imaging, 2020, 11(7): 535-539. DOI:10.12015/issn.1674-8034.2020.07.012.


[Abstract] Objective: To compare the value between intravoxel incoherent motion (IVIM) parameters and ADC value in assessing the histological differentiation grade of rectal adenocarcinoma.Materials and Methods: Ninety-three patients of rectal adenocarcinoma were enrolled and were analyzed MR images retrospectively. The parameters from IVIM (D, D*, f) and ADC value were measured. All parameters between different differentiation grade of rectal adenocarcinoma were compared. ROC analysis was used to assess the diagnostic performance in distinguishing well/moderately and poorly differentiated. Spearman correlation analyses were used among the IVIM parameters and histological differentiation grade.Results: There were significant differences in terms of ADC, D and f value between different differentiation grade of rectal adenocarcinoma (P=0.032, 0.000, 0.025 respectively). D value achieved the highest AUC in distinguishing well/moderately and poorly differentiated, when a cutoff value was 2.465×10-3 mm2/s, the sensitivity and specificity were 66.7% and 79.6%. The D value exhibited a moderate relationship with differentiation grade of rectal adenocarcinoma with |r| value of 0.441. The ADC and f value exhibited a poor relationship with differentiation grade, which |r| value were 0.249 and 0.246 respectively (all P<0.05).Conclusions: Both parameters from IVIM and ADC value could be helpful in differentiating histological differentiation grade of rectal adenocarcinoma. D value achieved the better diagnostic performance.
[Keywords] rectal cancer；magnetic resonance imaging；intravoxel incoherent motion

WENG Xiaoyan Department of Radiology, Affiliated Changshu Hospital of Soochow University, Changshu first people's Hospital, Changshu 215500, China

JIANG Heng Department of Radiology, Affiliated Changshu Hospital of Soochow University, Changshu first people's Hospital, Changshu 215500, China

JI Libiao Department of Radiology, Affiliated Changshu Hospital of Soochow University, Changshu first people's Hospital, Changshu 215500, China

LU Zhihua* Department of Radiology, Affiliated Changshu Hospital of Soochow University, Changshu first people's Hospital, Changshu 215500, China

*Correspondence to: Lu ZH, E-mail: luzhihua79@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This article is supported by the Jiangsu Provincial Medical Youth Talent No. QNRC2016212 Suzhou Clinical Special Disease Diagnosis and Treatment Program No. LCZX201823 Suzhou GuSu Medical Talent Project No. GSWS2019077 Science and Technology Bureau of Changshu No. CS201624
Received  2020-02-10
Accepted  2020-05-21
DOI: 10.12015/issn.1674-8034.2020.07.012
Cite this article as: Weng XY, Jiang H, Ji LB, et al. Comparison between IVIM parameters and ADC value in rectal cancer for estimate histological grade. Chin J Magn Reson Imaging, 2020, 11(7): 535-539. DOI:10.12015/issn.1674-8034.2020.07.012.

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