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• Clinical Article •
The advantage of advanced diffusion-weighted imaging compared with single index DWI in differentiating transitional zone prostate cancer and benign prostatic hyperplasia
REN Huipeng  FAN Qing  WANG Xiaohu  REN Zhuanqin 

Cite this article as: Ren HP, Fan Q, Wang XH, et al. The advantage of advanced diffusion-weighted imaging compared with single index DWI in differentiating transitional zone prostate cancer and benign prostatic hyperplasia. Chin J Magn Reson Imaging, 2020, 11(7): 552-556. DOI:10.12015/issn.1674-8034.2020.07.015.


[Abstract] Objective: To investigate the advantage of advanced diffusion-weighted imaging in the differential diagnosis of transitional zone prostate cancer (TZ-PCa) and benign prostatic hyperplasia (BPH) compared with single index diffusion-weighted imaging (DWI).Materials and Methods: Forty-eight patients with TZ-PCa and 56 patients with BPH confirmed by pathology were collected. All patients were scanned with conventional sequence, single index DWI and advanced diffusion weighted imaging sequence. advanced diffusion weighted imaging included introvoxel incoherent movement DWI (IVIM-DWI), stretched exponential DWI model (SEM) and diffusion kurtosis imaging (DKI). Measure the diffusion coefficients (ADC, ADCslow, DDC) from single index DWI, IVIM-DWI and SEM and average kurtosis (MK) from DKI, independent sample t-test was used to compare the differences of these parameters between the two groups. The ROC curve was used to evaluate the effectiveness of the parameters in the differential diagnosis of TZ-PCa and BPH, and the AUC between the parameters was compared by Z-test.Results: there were significant differences in ADC, ADCslow, DDC and MK between TZ-Ca and BPH (P<0.001). The diagnostic efficiency of MK, DDC, ADCslow, ADCslow+DDC+MK and ADC value were all higher (AUC> 0.9), the diagnostic efficiency of MK, DDC and ADCslow+DDC+MK was better than ADC value (P<0.05), the diagnostic efficiency of ADCslow+DDC+MK was the highest (AUC=1), and the combined parameters had better sensitivity and specificity than single parameters.Conclusions: advanced diffusion-weighted imaging is superior to the single index DWI in the differential diagnosis of TZ-PCa and BPH. ADCslow+DDC+MK can further improve the sensitivity and specificity of the diagnosis.
[Keywords] prostatic neoplasms；prostatic hyperplasia；magnetic resonance imaging；diffusion magnetic resonance imaging；diagnosis, differential

REN Huipeng Imaging Department of Baoji Central Hospital, Shaanxi Province, Baoji 721008, China

FAN Qing Imaging Department of Baoji Central Hospital, Shaanxi Province, Baoji 721008, China

WANG Xiaohu Imaging Department of Baoji Central Hospital, Shaanxi Province, Baoji 721008, China

REN Zhuanqin* Imaging Department of Baoji Central Hospital, Shaanxi Province, Baoji 721008, China

*Correspondence to: Ren ZQ, E-mail: renzhuanqin@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Scientific Research Project of Baoji Health and Family Planning Bureau No. 2017-06
Received  2019-12-19
Accepted  2010-05-20
DOI: 10.12015/issn.1674-8034.2020.07.015
Cite this article as: Ren HP, Fan Q, Wang XH, et al. The advantage of advanced diffusion-weighted imaging compared with single index DWI in differentiating transitional zone prostate cancer and benign prostatic hyperplasia. Chin J Magn Reson Imaging, 2020, 11(7): 552-556. DOI:10.12015/issn.1674-8034.2020.07.015.

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