Share：
Share this content in WeChat
X
[Chinese][PDF]1167155
• Experience Exchanges •
Value of DWI combined with MRS in glioma grade diagnosis
XIAO Guoqiang  WANG Shantao  XU Fenglin 

Cite this article as: Xiao GQ, Wang ST, Xu FL. Value of DWI combined with MRS in glioma grade diagnosis. Chin J Magn Reson Imaging, 2020, 11(7): 573-576. DOI:10.12015/issn.1674-8034.2020.07.019.


[Abstract] Objective: To analyze the value of diffusion weighted imaging (DWI) combined with hydrogen proton magnetic resonance spectroscopy (MRS) in glioma grade diagnosis.Materials and Methods: Between January 2017 and December 2018, 92 patients with glioma were selected as subjects, and grouped according to the results of DWI and MRS, of which 45 patients with grade Ⅰ to Ⅱ were classified into low-grade glioma group and 47 patients with grade Ⅲ to Ⅳ were classified into high-grade glioma group. All patients received DWI and MRS examinations. Various indexes were compared between groups, including apparent diffusion coefficient (ADC) value, N-acetylaspartate (NAA), creatine (Cr) and choline (Cho). The diagnostic value of DWI combined with MRS in different grades of gliomas was analyzed.Results: The ADC [(11.52±1.0)×10-3 mm2/s] and NAA/Cr in the low-grade group were significantly higher than those in the high-grade group ADC [(8.69±1.11)×10-3 mm2/s] and NAA/Cr (t=12.332, P<0.05; t=18.999, P<0.05). The Cho/Cr and Cho/NAA in the high-grade group were significantly higher than those in the low-garde group (t=34.164, P<0.05; t=40.962, P<0.05). Taking pathological diagnosis as gold standard, the sensitivity, specificity and accuracy of DWI examination were 77.78%, 76.60%, and 77.17%, respectively; the sensitivity, specificity and accuracy of MRS examination were 86.67%, 80.85%, and 83.70%; the sensitivity, specificity and accuracy of DWI combined with MRS were 93.33%, 95.74% and 94.57% (P<0.05). The diagnostic value of DWI and MRS was significantly lower than that of DWI combined with MRS (P<0.05).Conclusions: DWI combined with MRS parameters have certain clinical guiding value in glioma grade diagnosis with high sensitivity and specificity, which can provide some reference for clinical treatment and prognosis.
[Keywords] glioma；diffusion magnetic resonance imaging；magnetic resonance spectroscopy

XIAO Guoqiang* Department of Radiology, Xinjiang Cardiovascular and Cerebrovascular Disease Hospital, Urumqi 830011, China

WANG Shantao Department of Radiology, Xinjiang Cardiovascular and Cerebrovascular Disease Hospital, Urumqi 830011, China

XU Fenglin Department of Radiology, Xinjiang Cardiovascular and Cerebrovascular Disease Hospital, Urumqi 830011, China

*Corresponding to: XIAO GQ, E-mail: sbufbidcna@163.com

Conflicts of interest   None.

Received  2019-09-30
Accepted  2020-05-20
DOI: 10.12015/issn.1674-8034.2020.07.019
Cite this article as: Xiao GQ, Wang ST, Xu FL. Value of DWI combined with MRS in glioma grade diagnosis. Chin J Magn Reson Imaging, 2020, 11(7): 573-576. DOI:10.12015/issn.1674-8034.2020.07.019.

[1]
谭朝元，杨晶，严开心，等．扩散峰度成像对高级别胶质瘤及单发脑转移瘤的鉴别诊断价值．放射学实践, 2017, 32(3): 218-222.
[2]
Santangelo A, Imbrucè P, Gardenghi B, et al. A microRNA signature from serum exosomes of patients with glioma as complementary diagnostic biomarker. J Neurooncol, 2017, 136(1): 51-62.
[3]
张益杰，程敬亮，李娅．磁共振图像的纹理分析在界定高级别脑胶质瘤边界中的应用．临床放射学杂志, 2017, 36(3): 315-318.
[4]
He ZQ, Ke C, Alnahari F, et al. Low preoperative prognostic nutritional index predicts poor survival in patients with newly diagnosed high-grade gliomas. J Neurooncol, 2017, 132(2): 239-247.
[5]
关婷婷，王小宜，侯磊，等. DCE-MRI与脑胶质瘤级别及VEGF关系的研究．临床放射学杂志, 2018, 37(12): 25-31.
[6]
Shi C, Ren L, Sun C, et al. miR-29a/b/c function as invasion suppressors for gliomas by targeting CDC42 and predict the prognosis of patients. Br J Cancer, 2017, 117(7): 1036.
[7]
王伟，杨治花，折虹，等．扩散张量成像定量参数与脑胶质瘤病理参数的相关性．中国老年学杂志, 2017, 37(24): 6173-6175.
[8]
Lassaletta A, Strother D, Laperriere N, et al. Reirradiation in patients with diffuse intrinsic pontine gliomas: the Canadian experience. Pediatr Blood Cancer, 2018, 65(3): e26988.
[9]
吴亚平，刘博，顾建钦，等．基于影像组学的脑胶质瘤分级方法．中华放射学杂志, 2017, 51(12): 902-905.
[10]
中国脑胶质瘤协作组．中国脑胶质瘤分子诊疗指南附录．中华神经外科杂志, 2014, 30(5): 523-527.
[11]
苏昌亮，李丽，陈小伟，等. 2016年WHO中枢神经系统肿瘤分类总结.放射学实践, 2016, 31(7): 570-579.
[12]
Pal J, Patil V, Kumar A, et al. Abstract 2454: genetic landscape of glioma reveals defective neuroactive ligand receptor interaction pathway as a poor prognosticator in glioblastoma patients. Cancer Res, 2017, 77(Suppl 13): 2454-2454.
[13]
陈籽荣，王震，厉亚坤，等．儿童低级别胶质瘤的分子病理学特点和临床意义．中华医学杂志, 2018, 98(5): 390-393.
[14]
Wang J, Lu Z, Tang H, et al. Multiplexed electrochemical detection of MiRNAs from sera of glioma patients at different stages via the novel conjugates of conducting magnetic microbeads and diblock oligonucleotide-modified gold nanoparticles. Anal Chem, 2017, 89(20): 10834.
[15]
蒋海辉，李光，王军梅，等．新型中枢神经系统肿瘤分类对低级别胶质瘤患者预后的意义．中华医学杂志, 2018, 98(5): 332-335.
[16]
Toft A, Urup T, Christensen IJ, et al. Biomarkers in Recurrent Grade III Glioma Patients Treated with Bevacizumab and Irinotecan. Cancer Invest, 2018, 36(1): 165-174.
[17]
欧阳红，韩娜，张静，等．右小脑半球不典型室管膜瘤局部塑形生长一例并文献回顾．磁共振成像, 2018, 9(12): 79-80.
[18]
Moots RJ, Sebba A, Rigby W, et al. Effect of tocilizumab on neutrophils in adult patients with rheumatoid arthritis: pooled analysis of data from phase 3 and 4 clinical trials. Rheumatology, 2017, 56(4): 541-549.
[19]
林坤，次旦旺久，祁英，等．多模态磁共振成像技术在胶质瘤评价中的应用研究．磁共振成像, 2018, 9(1): 14-20.
[20]
Hurst NB, Lipe DN, Karpen SR, et al. Centruroidessculpturatus envenomation in three adult patients requiring treatment with antivenom. Clin Toxicol (Phila), 2018, 56(4): 294-296.

PREV Feasibility study on application of MAGiC sequence in sacroiliac joint of young volunteers
NEXT 3.0 T MRI double-echo hydro-lipid separation Dixon technique for quantitative determination of liver fat in patients with nonalcoholic fatty liver disease
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn