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Research progress on the effect of type 2 diabetes on the brain microstructure and structural network
YANG Liming  HUANG Mingming  YIN Yi  LIU Jing  YU Hui 

Cite this article as: Yang LM, Huang MM, Yin Y, et al. Research progress on the effect of type 2 diabetes on the brain microstructure and structural network. Chin J Magn Reson Imaging, 2020, 11(7): 589-592. DOI:10.12015/issn.1674-8034.2020.07.023.


[Abstract] Type 2 diabetes Mellitus (T2DM) is a chronic metabolic disease with multiple system complications. In addition to the well-known renal, eye, foot, and cardiovascular complications, T2DM can cause central nervous system dysfunction, characterized by a multidisciplinary decline in cognitive function. Due to its insidious onset, the key of treatment is to early diagnosis and timely intervention. Diffusion tensor imaging (DTI) can non-invasively detect the changes of the microstructure of living tissue. In recent years, the application of this technique in neuroimaging of T2MD has made a lot of achievements, finding out the changes of the microstructure of many brain regions in patients with T2DM, and the changes of the microstructure of local brain regions have significant correlation with cognitive ability and clinical parameters. In addition, DTI combined with graph theory can provide a quantitative characterization of the changes in white matter connectivity, which provides a new insight into the pathogenesis of cognitive decline in patients with T2DM. Therefore, this article will review the progress of neuroimaging in patients with type 2 diabetes from the above two aspects.
[Keywords] diabetes mellitus, type 2；nerve net；cognition disorders；magnetic resonance imaging

YANG Liming Department of Radiology, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China

HUANG Mingming Department of Radiology, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China

YIN Yi Department of Radiology, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China

LIU Jing Department of Radiology, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China

YU Hui* Department of Radiology, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China

*Corresponding to: Yu H, E-mail: 331693861@qq.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This article is supported by the National Natural Science Found No. 81560281 and the Guiyang Science and Technology Bureau Fund No. 2017-5-8
Received  2020-01-22
Accepted  2020-05-21
DOI: 10.12015/issn.1674-8034.2020.07.023
Cite this article as: Yang LM, Huang MM, Yin Y, et al. Research progress on the effect of type 2 diabetes on the brain microstructure and structural network. Chin J Magn Reson Imaging, 2020, 11(7): 589-592. DOI:10.12015/issn.1674-8034.2020.07.023.

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